Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Nature

• Publication date

  1989-02-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/337562A0PMID 2783762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

  1988cited by this paper
• T cell tolerance by clonal elimination in the thymus.

  1987cited by this paper
• The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice

  1987cited by this paper
• Transgenic mice with immunoglobulin genes.

  1987cited by this paper
• Quantitative Evidence Against Inactivation of Self‐Reactive B‐Cell Clones

  1986cited by this paper
• Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides.

  1985cited by this paper
• Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

  1985cited by this paper
• Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection.

  1983cited by this paper
• A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness

  1982cited by this paper
• Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.

  1981cited by this paper
• Tolerance as an active process

  1980cited by this paper
• Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

  1980cited by this paper
• 5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains.

  1980cited by this paper
• Relative sensitivity of fetal and newborn mice to induction of hapten- specific B cell tolerance

  1980cited by this paper
• Induction of tolerance in athymic mice with an antigen which is highly immunogenic in euthymic mice.

  1977cited by this paper
• Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen

  1976cited by this paper
• Receptor-mediated inactivation of early B lymphocytes

  1975cited by this paper
• Induction of immunological tolerance by a hapten (DNP) bound to a non-immunogenic protein carrier.

  1971cited by this paper
• Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

  1971cited by this paper
• A Theory of Self-Nonself Discrimination

  1970cited by this paper
• Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

  1962cited by this paper

• Seeking tolerance in immunology: Looking back, looking forward

  2025cites this paper
• Lymphoma driver mutations at the root of somatic evolution of nerve-damaging autoantibodies in myelin associated glycoprotein neuropathy.

  2025cites this paper
• B cells and aging: a historical perspective.

  2025cites this paper
• The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses.

  2025cites this paper
• Mechanisms of B Cell Tolerance in Health and Autoimmunity.

  2025cites this paper
• Self‐Antigens Select B Cells: A New Perspective on B Cell Selection and Function

  2025cites this paper
• Development and consequences of red blood cell autoantibodies: warm autoimmune hemolytic anemia.

  2025cites this paper
• ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains

  2025cites this paper
• Dynamic control of autoreactive B cells from spontaneous germinal centers.

  2025cites this paper
• CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model.

  2025cites this paper
• Peripheral apoptosis and limited clonal deletion during physiologic murine B lymphocyte development

  2024cites this paper
• Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

  2024cites this paper
• B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis

  2024cites this paper
• Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

  2024cites this paper
• Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells

  2024cites this paper
• T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms

  2024cites this paper
• Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion

  2024cites this paper
• Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host

  2024cites this paper
• Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

  2023cites this paper
• Mechanismen immunologischer Toleranz und ihrer Dysregulation bei rheumatischen Erkrankungen

  2023cites this paper
• CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells.

  2023cites this paper
• Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

  2023cites this paper
• Aberrant Activation of Immune and Non-Immune Cells Contributes to Joint Inflammation and Bone Degradation in Rheumatoid Arthritis

  2023cites this paper
• Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

  2023cites this paper
• CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells

  2023cites this paper
• Peripheral death by neglect and limited clonal deletion during physiologic B lymphocyte development

  2023cites this paper
• Therapeutic induction of antigen-specific immune tolerance

  2023cites this paper
• Toll-like receptors 7 and 9 regulate the proliferation and differentiation of B cells in systemic lupus erythematosus

  2023cites this paper
• Interleukin 4-driven reversal of self-reactive B cell anergy contributes to the pathogenesis of systemic lupus erythematosus

  2023cites this paper
• B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells *

  2022cites this paper
• Insights Into the Host Contribution of Endocrine Associated Immune-Related Adverse Events to Immune Checkpoint Inhibition Therapy

  2022cites this paper
• Adaptive tolerance: Protection through self‐recognition

  2022cites this paper
• LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway

  2022cites this paper
• Transforming mutations in the development of pathogenic B cell clones and autoantibodies *

  2022cites this paper
• Chasing shadows: Cytologically detected shadow cells in the cerebrospinal fluid of patients with multiple sclerosis.

  2022cites this paper
• B cells, the bursa of Fabricius, and the generation of antibody repertoires

  2022cites this paper
• Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease

  2022influential citation
• Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

  2022cites this paper
• B cells in the balance: Offsetting self-reactivity avoidance with protection against foreign

  2022cites this paper
• Rheumatoid factor IgM autoantibodies control IgG homeostasis

  2022cites this paper
• POSITIONAL CLONING OF POLYMORPHIC LOCI THAT CONTROL AUTOREACTIVE T CELLS

  2021cites this paper
• B Cells in Primary Membranous Nephropathy: Escape from Immune Tolerance and Implications for Patient Management

  2021cites this paper
• Primary Immune Responses and Affinity Maturation Are Controlled by IgD

  2021influential citation
• Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse

  2021cites this paper
• Memory IgM protects endogenous insulin from autoimmune destruction

  2021cites this paper
• Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice

  2021cites this paper
• Genome edited B cells: a new frontier in immune cell therapies.

  2021cites this paper
• Defective Allelic Exclusion by IgD in the Absence of Autoantigen

  2021cites this paper
• Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models

  2020cites this paper
• B Cell Development and Maturation.

  2020cites this paper
• Age-Associated B Cells.

  2020cites this paper
• Mechanisms of HBV immune evasion.

  2020cites this paper
• Safety Profile of a Virus-Like Particle-Based Vaccine Targeting Self-Protein Interleukin-5 in Horses

  2020cites this paper
• An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells

  2020cites this paper
• B Cell Activation and B Cell Tolerance

  2020cites this paper
• Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.

  2020cites this paper
• Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.

  2020cites this paper
• Role of Specific B-Cell Receptor Antigens in Lymphomagenesis

  2020cites this paper
• A rheostat sets B-cell receptor repertoire selection to distinguish self from non-self.

  2020cites this paper
• Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1

  2020cites this paper
• A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations

  2020cites this paper
• Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural.

  2020cites this paper
• Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance

  2020cites this paper
• Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

  2020cites this paper
• Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

  2019cites this paper
• Generation and Utilization of Diverse Memory B Cells After Flavivirus Challenges

  2019cites this paper
• Monoclonal Immunoglobulin

  2019cites this paper
• Plasma cell differentiation during the germinal center reaction

  2019cites this paper
• B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

  2019cites this paper
• Signalling circuits that direct early B-cell development.

  2019cites this paper
• Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5

  2019cites this paper
• Characterisation of naïve and antigen-experienced human antibody repertoires

  2019cites this paper
• Self‐reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

  2019influential citation
• Minding the gap: The impact of B‐cell tolerance on the microbial antibody repertoire

  2019cites this paper
• A Precision B Cell–Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation

  2019influential citation
• Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

  2019cites this paper
• B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.

  2019cites this paper
• Immunogénétique et développement des lymphocytes T CD4-CD8- immunorégulateurs chez la souris

  2019cites this paper
• Metabolic gatekeepers to safeguard against autoimmunity and oncogenic B cell transformation

  2019cites this paper
• Active PI3K abrogates central tolerance in high-avidity autoreactive B cells

  2019cites this paper
• Techniques to Study Antigen-Specific B Cell Responses

  2019cites this paper
• Investigation of the adaptive immune response in multiple sclerosis

  2018cites this paper
• Autoimmunität und Transplantation

  2018cites this paper
• Unravelling the role of the microenvironment in chronic lymphocytic leukaemia: T helper cell support of cancer cells

  2018cites this paper
• Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance

  2018cites this paper
• Targeting the CD4 Binding Site of HIV

  2018cites this paper
• Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy

  2018influential citation
• Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design

  2018cites this paper
• Self-Reactive B Cells in the Germinal Center Reaction.

  2018cites this paper
• Assessing human B cell repertoire diversity and convergence

  2018cites this paper
• Redemption for self-reactive antibodies

  2018cites this paper
• Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity

  2018cites this paper
• The enigmatic function of IgD: some answers at last

  2018cites this paper
• Autoimmunity checkpoints as therapeutic targets in B cell malignancies

  2018cites this paper
• Effets de différents modèles de stress sur le développement lymphocytaire

  2018cites this paper
• Tracing Self-Reactive B Cells in Normal Mice

  2018cites this paper
• Introduction to Translational Immunotherapy for Brain Tumors

  2017cites this paper
• Compartment and Reveals Mutations Defines a B Cell Central Tolerance Negative Selection by IgM Superantigen

  2017cites this paper
• Tolerance by Anti-Double-Stranded DNA B T Cell-Independent Spontaneous Loss of

  2017cites this paper
• The anti-insulin B cell receptor in autoimmune diabetes

  2017cites this paper