Properties and functions of calmodulin.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Biochemical Pharmacology

• Publication date

  1981-06-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-2952(81)90358-0PMID 6268098
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Calcium- and magnesium-dependent conformational states of calmodulin as determined by nuclear magnetic resonance.

  1980cited by this paper
• Biochemical properties of hormone-sensitive adenylate cyclase.

  1980cited by this paper
• Ligand binding to macromolecules: determination of binding parameters by combined use of ligand buffers and flow dialysis; application to calcium-binding proteins.

  1980cited by this paper
• Stimulation of Adenylate Cyclase by Ca2+ and Calmodulin in Rat Islets of Langerhans: Explanation for the Glucose-induced Increase in Cyclic AMP Levels

  1980cited by this paper
• Regulation and kinetics of the actin-myosin-ATP interaction.

  1980cited by this paper
• Calmodulin activation of red blood cell (Ca2+ + Mg2+)-ATPase and its antagonism by phenothiazines.

  1980cited by this paper
• Ca2+-dependent regulation of guinea pig brain adenylate cyclase.

  1980cited by this paper
• Calcium regulation of guanine nucleotide activation of hepatic adenylate cyclase.

  1980cited by this paper
• Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

  1980cited by this paper
• Calmodulin plays a pivotal role in cellular regulation.

  1980cited by this paper
• Homologous calcium-binding proteins in the activation of skeletal, cardiac, and smooth muscle myosin light chain kinases.

  1980cited by this paper
• Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.

  1980cited by this paper
• Ca2+ regulation in vascular smooth muscle. II. Ca2+ binding of aorta leiotonin.

  1980cited by this paper
• Calmodulin-activated protein kinase activity of adipocyte microsomes.

  1980cited by this paper
• Evidence for three distinct forms of calmodulin‐dependent protein kinases from rat brain

  1980cited by this paper
• Calmodulin-dependent glycogen synthase kinase.

  1980cited by this paper
• The effect of calmodulin on the active calcium-ion transport and (Ca2+ + Mg2+)-dependent ATPase in microsomal fractions of smooth muscle compared with that in erythrocytes and cardiac muscle.

  1980cited by this paper
• The complete amino acid sequence of the Ca2+-dependent modulator protein (calmodulin) of bovine brain.

  1980cited by this paper
• Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin.

  1980cited by this paper
• Calmodulin—an intracellular calcium receptor

  1980cited by this paper
• Calmodulin activates prokaryotic adenylate cyclase.

  1980cited by this paper
• Calmodulin.

  1980cited by this paper
• Calcium sensitivity of sea urchin tubulin in in vitro assembly and the effects of calcium-dependent regulator (CDR) proteins isolated from sea urchin eggs and porcine brains.

  1980cited by this paper
• Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

  1980cited by this paper
• Cardiac calmodulin and its role in the regulation of metabolism and contraction.

  1980cited by this paper
• The effect of calmodulin and troponin-C on activities of homogeneous liver phosphoprotein phosphatases.

  1980cited by this paper
• Stimulation of phosphorylase b kinase by the calcium-dependent regulator.

  1980cited by this paper
• Localization of calmodulin in rat tissues.

  1980cited by this paper
• Myosin light chain phosphorylation and phosphorylase A activity in rat extensor digitorum longus muscle.

  1979cited by this paper
• Adenylate Cyclase in Silkworm: Regulation by Calcium and a Calcium-binding Protein

  1979cited by this paper
• Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

  1979cited by this paper
• Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy.

  1979cited by this paper
• Calcium and calmodulin activation of muscle phosphorylase kinase

  1979cited by this paper
• Stimulation of glycogen synthase phosphorylation by calcium-dependent regulator protein.

  1979cited by this paper
• Activation of phosphorylase kinase from rabbit skeletal muscle by calmodulin and troponin

  1979cited by this paper
• Occurrence of A Ca2+ ‐ and modulator protein‐activatable ATPase in the synaptic plasma membranes of brain

  1979cited by this paper
• Calmodulin activation of adenylate cyclase in pancreatic islets.

  1979cited by this paper
• Properties of (Mg2 + Ca2+)-ATPase of erythrocyte membranes prepared by different procedures: influence of Mg2+, Ca2+, ATP, and protein activator.

  1979cited by this paper
• Calmodulin and myosin light-chain kinase of rabbit fast skeletal muscle.

  1979cited by this paper
• Calmodulin and its role in the second-messenger system.

  1979cited by this paper
• Purification of a cyclic nucleotide phosphodiesterase from bovine brain using blue dextran-Sepharose chromatography.

  1979cited by this paper
• Calcium dependence of hormone-stimulated cAMP accumulation in intact glial tumor cells.

  1979cited by this paper
• Regulation of calcium translocation across the red blood cell membrane

  1979cited by this paper
• Inability of parvalbumin to function as a calcium-dependent activator of cyclic nucleotide phosphodiesterase activity.

  1979cited by this paper
• Cross-linking of iodine-125-labeled, calcium-dependent regulatory protein to the Ca2+-sensitive phosphodiesterase purified from bovine heart.

  1979cited by this paper
• Calcium transport across the plasma membrane: stimulation by calmodulin.

  1979cited by this paper
• Metabolism of prostacyclin in the rabbit kidney.

  1979cited by this paper
• Phosphorylation of glycogen synthase by phosphorylase kinase

  1979cited by this paper
• Chinese hamster ovary cell population density affects intracellular concentrations of calcium-dependent regulator and ability of regulator to inhibit adenylate cyclase activity.

  1979cited by this paper
• The interactions between calcium-dependent regulator protein of cyclic nucleotide phosphodiesterase and microtubule proteins. I. Effect of calcium-dependent regulator protein on the calcium sensitivity of microtubule assembly.

  1979cited by this paper
• Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.

  1979cited by this paper
• Glycogen synthase kinase-2 and phosphorylase kinase are the same enzyme.

  1979cited by this paper
• The interactions between calcium-dependent regulator protein of cyclic nucleotide phosphodiesterase and microtubule proteins. II. Association of calcium-dependent regulator protein with tubulin dimer.

  1979cited by this paper
• Ca2+-binding modulator protein in protozoa and myxomycete.

  1979cited by this paper
• The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.

  1979cited by this paper
• Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium--calmodulin-dependent phosphorylations.

  1979cited by this paper
• Glycogen synthase kinase‐2 from rabbit skeletal muscle is activated by the calcium‐dependent regulator protein

  1979cited by this paper
• Circular dichroism studies of native and chemically modified Ca2+-dependent protein modulator.

  1979cited by this paper
• The protein kinase properties of calsequestrin

  1979cited by this paper
• Activation of tryptophan 5-monooxygenase by calcium-dependent regulator protein.

  1979cited by this paper
• A calcium‐dependent protein activator of mammalian cyclic nucleotide phosphodiesterase from Blastocladiella emersonii

  1979cited by this paper
• Interaction of soluble brain adenylate cyclase with manganese.

  1979cited by this paper
• Subunit structure and catalytic properties of bovine brain Ca2+-dependent cyclic nucleotide phosphodiesterase.

  1979cited by this paper
• Properties and functions of the calcium-dependent regulator protein.

  1979cited by this paper
• Calmodulin stimulates human platelet phospholipase A2.

  1979cited by this paper
• Evidence for a dissociable protein subunit required for calmodulin stimulation of brain adenylate cyclase.

  1979cited by this paper
• Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity.

  1979cited by this paper
• Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells.

  1979cited by this paper
• Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography.

  1979cited by this paper
• Identification of the Ca2+‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

  1978cited by this paper
• Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins.

  1978cited by this paper
• Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells.

  1978cited by this paper
• Membrane-bound protein modulator and phosphodiesterase.

  1978cited by this paper
• Phosphodiesterase protein activator stimulates calcium transport in cardiac microsomal preparations enriched in sarcoplasmic reticulum.

  1978cited by this paper
• Control of microtubule assembly-disassembly by calcium-dependent regulator protein.

  1978cited by this paper
• Stimulation of calcium transport in inside-out vesicles of human erythrocyte membranes by a soluble cytoplasmic activator.

  1978cited by this paper
• Purification of the Ca2+-stimulated ATPase activator from human erythrocytes. Its membership in the class of Ca2+-binding modulator proteins.

  1978cited by this paper
• Rat liver adenylate cyclase and phosphodiesterase dependence on Ca2+ and on cytoplasmic factors during liver regeneration

  1978cited by this paper
• The amino acid sequence of the troponin C‐like protein (modulator protein) from bovine uterus

  1978cited by this paper
• Ca2+-stimulated phosphorylation of muscle glycogen synthase by phosphorylase b kinase.

  1978cited by this paper
• Calcium dependent neurotransmitter release and protein phosphorylation in synaptic vesicles.

  1978cited by this paper
• Specific visualization of the distribution of the calcium dependent regulatory protein of cyclic nucleotide phosphodiesterase (modulator protein) in tissue culture cells by immunofluorescence microscopy: mitosis and intercellular bridge.

  1978cited by this paper
• Calcium-dependent regulator of NAD kinase in higher plants

  1978cited by this paper
• Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

  1978cited by this paper
• Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase.

  1978cited by this paper
• Involvement of an acidic protein in regulation of smooth muscle contraction by the tropomyosin-leiotonin system.

  1978cited by this paper
• Calcium-dependent regulation of NAD kinase.

  1978cited by this paper
• Identification of an activator protein for myosin light chain kinase as the Ca2+-dependent modulator protein.

  1978cited by this paper
• Specific binding of the calcium-dependent regulation protein to brain membranes from the guinea pig.

  1978cited by this paper
• Purification of modulator-deficient myosin light-chain kinase by modulator protein-Sepharose affinity chromatography.

  1978cited by this paper
• Calcium-dependent adenylate cyclase from rat cerebral cortex: activation by guanine nucleotides.

  1978cited by this paper
• Modulator protein as a Ca2+-dependent activator of rabbit skeletal myosin light-chain kinase. Purification and characterization.

  1978cited by this paper
• Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

  1978cited by this paper
• Purification of a Ca2+-activatable cyclic nucleotide phosphodiesterase from bovine heart by specific interaction with its Ca2+-dependent modulator protein.

  1977cited by this paper
• Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C.

  1977cited by this paper
• Does phosphorylation of myosin light chain have direct relation to regulation in smooth muscle?

  1977cited by this paper
• Divalent cation binding properties of bovine brain Ca2+-dependent regulator protein.

  1977cited by this paper
• The effect of Mg2+ on the Ca2+-binding properties of non-activated phosphorylase kinase.

  1977cited by this paper
• Choleragen activation of solubilized adenylate cyclase: requirement for GTP and protein activator for demonstration of enzymatic activity.

  1977cited by this paper
• Ca-regulation of mammalian smooth muscle actomyosin via a kinase-phosphatase-dependent phosphorylation and dephosphorylation of the 20 000-Mr light chain of myosin.

  1977cited by this paper

• Calmodulin in Paramecium: Focus on Genomic Data

  2022cites this paper
• Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release.

  2013cites this paper
• Use of Allosteric Targets in the Discovery of Safer Drugs

  2013cites this paper
• Functional Aspects of the Normal, Hypertrophied, and Failing Heart

  2011cites this paper
• Syntheses and Uses of Isotopically Labelled Organic Halides

  2009cites this paper
• Effects of trifluoperazine on beta-adrenergic responses of rat papillary muscle: related to calmodulin?

  2009cites this paper
• Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor.

  2006cites this paper
• Plasticity of the electroexcitable membrane of the neuron under conditions of calmodulin blockade

  2005cites this paper
• Involvement of calmodulin inhibition in analgesia induced with low doses of intrathecal trifluoperazine.

  2002cites this paper
• Mast cells and peptide induced histamine release

  2001influential citation
• Ca2+ dependency of serotonin and dopamine release from CNS slices of chronically isolated rats

  1998cites this paper
• Hydrogen peroxide‐induced cytoskeletal rearrangement in cultured pulmonary endothelial cells

  1998cites this paper
• Effects of Fluorescent Reporter Group Structure on the Dynamics Surrounding Cysteine-26 in Spinach Calmodulin: A Model Biorecognition Element

  1998cites this paper
• Self-organization in biology and development.

  1997cites this paper
• Erythrocytes may synthesize their own nitric oxide.

  1996cites this paper
• Droperidol inhibits tracheal contraction induced by serotonin, histamine or carbachol in guinea pigs

  1996cites this paper
• Calcium-binding proteins 1: EF-hands.

  1995cites this paper
• Calmodulin and In Vitro Regenerating Frog Sciatic Nerves: Release and Extracellular Effects

  1995cites this paper
• Calcium-binding proteins. 1: EF-hands.

  1994cites this paper
• Evidence that lead acts as a calcium substitute in second messenger metabolism.

  1993cites this paper
• Possible link between zinc intake and colon cancer.

  1993cites this paper
• Effects of calmodulin inhibitors on amylase secretion from rat pancreatic acini.

  1993cites this paper
• Calmodulin and dynamics of interactions of cytosolic enzymes.

  1992cites this paper
• Binding of [3H]SCH23390 to a non-dopaminergic site in bovine kidney.

  1992cites this paper
• Effect of modulated shf electromagnetic fields on calmodulin levels in brain structures

  1992cites this paper
• Search for cyclo-AMP phosphodiesterase inhibitors by means of substructural and topological descriptors

  1991cites this paper
• Mechanisms of lead neurotoxicity.

  1991cites this paper
• Hemocytes of Pomacea canaliculata: I. Reversible aggregation induced by Ca2+.

  1990cites this paper
• Effects of drugs on calmodulin-mediated enzymatic actions.

  1989cites this paper
• Divalent cation dependence of the inhibition by phenothiazines of mediator release from mast cells

  1989cites this paper
• Cellular Regulation of Pancreatic Secretion

  1989cites this paper
• [Clinical significance of cyclic nucleotide metabolism and calcium level in children with arrhythmia].

  1989cites this paper
• [Calmodulin: its physiological and pharmacological properties].

  1988cites this paper
• Characteristics of the binding of phenoxybenzamine to calmodulin.

  1988cites this paper
• Biochemistry of the nervous system.

  1987cites this paper
• Differential inhibition of calmodulin-sensitive phosphodiesterase and Ca++-adenosine triphosphatase by chlorpromazine-linked calmodulin.

  1987cites this paper
• Calmodulin and the Secretory Vesicle a

  1987cites this paper
• Involvement of calmodulin-calcium complex in regulation of O2 uptake in regions of the liver lobule.

  1987cites this paper
• Calmodulin-mediated cadmium inhibition of phosphodiesterase activity, in vitro

  1987cites this paper
• Compartmentalization of calmodulin and tubulin in the male C57BL/6J mouse brain: heterogeneity of age changes in calmodulin compartments.

  1987cites this paper
• Calmodulin and its role in intracellular calcium regulation.

  1987cites this paper
• Calmodulin activates adenylate cyclase from rat anterior pituitary.

  1987cites this paper
• Calmodulin‐Dependent Phosphatases of PC12, GH3, and C6 Cells: Physical, Kinetic, and Immunochemical Properties

  1987cites this paper
• Calmodulin regulation of the cholinergic receptor in the rat heart during ontogeny and senescence.

  1986cites this paper
• Calmodulin: a potential target for cancer chemotherapeutic agents.

  1986cites this paper
• The effects of calmodulin antagonists on prostaglandin E2-induced responses in rat calvarial bone cells.

  1986cites this paper
• Calcium-activated, calmodulin-dependent protein kinase activity in bovine thyroid cytosol.

  1986cites this paper
• Calmodulin-binding proteins and calmodulin-regulated enzymes in dog pancreas.

  1986cites this paper
• The mechanism of the effect of K+ on the steroidogenesis of rat zona glomerulosa cells of the adrenal cortex: role of cyclic AMP

  1986cites this paper
• Effects of phenothiazines on phosphate incorporation and chloride uptake in isolated intestinal epithelial cells.

  1986cites this paper
• Regulatory effect of calcium on 3H-dopamine binding to guinea-pig heart membrane preparations.

  1985cites this paper
• Mechanisms of Pharmacologically Altering Calmodulin Activity

  1985cites this paper
• Effects of Opioids

  1985cites this paper
• 2 – Cell Surface Receptors and Transduction Mechanisms

  1985cites this paper
• Calcium and calmodulin in the regulation of human thyroid adenylate cyclase activity.

  1985cites this paper
• Historical and Biological Aspects of Calcium Action

  1985cites this paper
• Calcium Regulation of Histamine Secretion from Mast Cells

  1985cites this paper
• [ATPase activity of the heart microsomes, the regulation of calcium transport in the microsomes and the calmodulin content in experimental myocardial infarct].

  1985cites this paper
• Inhibitory effect of sodium salicylate on ADP-induced platelet aggregation and on 45Ca2+ uptake into platelets.

  1985cites this paper
• Calmodulin levels in hypertensive rats.

  1985cites this paper
• Chromaffin cell cytoskeleton: its possible role in secretion.

  1985cites this paper
• ATPase activity of cardiac microsomes, regulation of calcium transport in them, and calmodulin levels in experimental myocardial infarction

  1985cites this paper
• Vesicular demyelination induced by raised intracellular calcium.

  1985cites this paper
• Analysis of the relationship between the inhibition of the cyclic AMP phosphodiesterase activity and pharmacological action of drugs

  1985cites this paper
• Calmodulin activation of cyclic AMP phosphodiesterase in the B16 mouse melanoma.

  1984cites this paper
• Mechanism of action of cardiovascular drugs-calcium blockers (review)

  1984cites this paper
• Calmodulin-induced feeding in the cat: attenuation by calcium chelator EGTA.

  1984cites this paper
• Calmodulin during development and metamorphosis in urodelan amphibians.

  1984cites this paper
• Interaction of quaternary phenothiazine salts with calmodulin.

  1984cites this paper
• Activation of protein kinase activity in pancreatic acini by calcium and cAMP.

  1984cites this paper
• Identification of Calcium Channels with Radiolabelled Calcium Blockers

  1984cites this paper
• Phenothiazines cause a shift in the cAMP dose‐response: Selection of resistant variants in a murine thymoma line

  1984cites this paper
• The nature of the increased sensitivity to injected GTP of the sodium efflux in barnacle muscle fibers pre-exposed to aldosterone.

  1984cites this paper
• Biopharmacological Properties of Naphthalenesulfonamides as Potent Calmodulin Antagonists

  1984cites this paper
• Calcium entry blockers (calcium antagonists)

  1984cites this paper
• The inhibitory effect of phenothiazines on NK-mediated cytolysis of tumor cells.

  1984cites this paper
• Evidence for the presence of calmodulin in fish mucus.

  1984cites this paper
• Calmodulin activation of adenylate cyclase in the mouse B16 melanoma.

  1984cites this paper
• Phosphorylation of myosin light chain and phosphorylase in tracheal smooth muscle in response to KCl and carbachol.

  1984cites this paper
• [Plasticity of the electroexcitable membrane of a neuron after blocking with calmodulin].

  1984cites this paper
• Regulation of Myosin Phosphorylation in Smooth Muscle

  1984cites this paper
• Studies of the mechanism of noradrenaline stimulation of fluid absorption by rat jejunum in vitro.

  1984cites this paper
• Pain threshold and morphine activity in vitamin D-deficient rats.

  1984cites this paper
• Inhibition of (H+ + K+)-ATPase and H+ accumulation in hog gastric membranes by trifluoperazine, verapamil and 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate.

  1984cites this paper
• Sensitivity to injected cholera toxin of the sodium efflux in single barnacle muscle fibers.

  1984cites this paper
• Adrenal Chromaffin Cell Calmodulin: Its Subcellular Distribution and Binding to Chromaffin Granule Membrane Proteins

  1984cites this paper
• Calmodulin-induced feeding in the satiated cat: evidence for involvement of calcium and norepinephrine in the brain.

  1984cites this paper
• The effects of chronic renal failure and hemodialysis on human red and white cell calmodulin levels.

  1984cites this paper
• Interaction of various peptides with calmodulin.

  1984cites this paper
• Improved detection of calcium-binding proteins in polyacrylamide gels.

  1984cites this paper
• Calmodulin Stimulation of Ca2+‐Dependent ATP Hydrolysis and ATP‐Dependent Ca2+ Transport in Synaptic Membranes

  1983cites this paper
• Increased sensitivity to injected 5'-guanylylimidodiphosphate of the sodium efflux in barnacle muscle fibres preexposed to aldosterone.

  1983cites this paper
• Effects of psychoactive drugs on cyclic nucleotides in the central nervous system.

  1983cites this paper
• Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments.

  1983cites this paper
• Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory.

  1983cites this paper
• Calmodulin infused intracerebroventricularly enhances food intake in the cat.

  1983cites this paper
• A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands.

  1983cites this paper
• Effects of local anesthetics on calmodulin-dependent guanylate cyclase in the plasma membrane of Tetrahymena pyriformis.

  1983cites this paper
• Studies of calmodulin structure: laser raman spectroscopy of biomolecules.

  1983cites this paper
• African trypanosomes contain calmodulin which is distinct from host calmodulin.

  1983cites this paper