B cells and aging: molecules and mechanisms.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Trends in immunology

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2009.04.005PMID 19540810PMCID PMC2766868
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stem cells and the aging hematopoietic system.

  2010cited by this paper
• Immune Senescence: Deficiency or Dysregulation

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• Stem cells and aging in the hematopoietic system.

  2009cited by this paper
• B-cell diversity decreases in old age and is correlated with poor health status

  2009cited by this paper
• Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression1

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• The ageing immune system: is it ever too old to become young again?

  2009cited by this paper
• Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells1

  2008cited by this paper
• Mechanisms for Decreased Function of B Cells in Aged Mice and Humans1

  2008cited by this paper
• Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging

  2008cited by this paper
• Accelerated Notch-Dependent Degradation of E47 Proteins in Aged B Cell Precursors Is Associated with Increased ERK MAPK Activation1

  2007cited by this paper
• Immunosenescence of ageing

  2007cited by this paper
• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

  2007cited by this paper
• Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA1

  2007cited by this paper
• Correction of age-associated deficiency in germinal center response by immunization with immune complexes.

  2007cited by this paper
• Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential

  2007cited by this paper
• Diversity of the Ig Repertoire is Maintained With Age In Spite of Reduced Germinal Centre Cells in Human Tonsil Lymphoid Tissue

  2006cited by this paper
• Gene regulatory networks and the determination of lymphoid cell fates.

  2006cited by this paper
• Analysis of the young and elderly variable gene repertoire in response to pneumococcal polysaccharides using a reconstituted SCID mouse model.

  2006cited by this paper
• Identification of a B-1 B cell–specified progenitor

  2006cited by this paper
• Immune Response to Pneumococcal Polysaccharides 4 and 14 in Elderly and Young Adults: Analysis of the Variable Light Chain Repertoire

  2005cited by this paper
• Cell intrinsic alterations underlie hematopoietic stem cell aging.

  2005cited by this paper
• RNA Stability of the E2A-Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice1

  2005cited by this paper
• Immune Response to Pneumococcal Polysaccharides 4 and 14 in Elderly and Young Adults: Analysis of the Variable Heavy Chain Repertoire

  2005cited by this paper
• Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells.

  2005cited by this paper
• B cells, E2A, and aging

  2005cited by this paper
• Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice

  2004cited by this paper
• Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

  2004cited by this paper
• Antibody diversity: one enzyme to rule them all

  2004influential reference
• Age-related differences in the E2A-encoded transcription factor E47 in bone marrow-derived B cell precursors and in splenic B cells.

  2004cited by this paper
• Rectification of age-related impairment in Ig gene hypermutation during a memory response.

  2004cited by this paper
• Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover1

  2004cited by this paper
• Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase1

  2004cited by this paper
• The age-related decrease in E47 DNA-binding does not depend on increased Id inhibitory proteins in bone marrow-derived B cell precursors.

  2003cited by this paper
• E-proteins directly regulate expression of activation-induced deaminase in mature B cells

  2003influential reference
• Notch‐induced E2A ubiquitination and degradation are controlled by MAP kinase activities

  2003influential reference
• The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors 1

  2003cited by this paper
• Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes.

  2003cited by this paper
• B cell precursors in senescent mice exhibit decreased recruitment into proliferative compartments and altered expression of Bcl-2 family members.

  2003cited by this paper
• Altered Regulation of FcγRII on Aged Follicular Dendritic Cells Correlates with Immunoreceptor Tyrosine-Based Inhibition Motif Signaling in B Cells and Reduced Germinal Center Formation 1

  2003cited by this paper
• Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

  2002cited by this paper
• Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire1

  2002cited by this paper
• Aging and developmental transitions in the B cell lineage.

  2002cited by this paper
• The Unique Antigen Receptor Signaling Phenotype of B-1 Cells Is Influenced by Locale but Induced by Antigen1

  2002cited by this paper
• An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

  2001cited by this paper
• Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation.

  2001cited by this paper
• Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.

  2001cited by this paper
• Immunosenescence and infectious diseases.

  2001cited by this paper
• Immunosenescence: a review.

  2001cited by this paper
• Resource competition determines selection of B cell repertoires.

  2001cited by this paper
• Maturation of Marginal Zone and Follicular B Cells Requires B Cell Activating Factor of the Tumor Necrosis Factor Family and Is Independent of B Cell Maturation Antigen

  2001cited by this paper
• Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers.

  2001cited by this paper
• The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins.

  2000cited by this paper
• BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth

  1999influential reference
• BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.

  1999influential reference
• Immunoglobulin VH gene expression in human aging.

  1999cited by this paper
• B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

  1999cited by this paper
• The role of the B cell receptor V region in peripheral B cell survival

  1998cited by this paper
• Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment.

  1998cited by this paper
• Cutting Edge: Senescent BALB/c Mice Exhibit Decreased Expression of λ5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment

  1998cited by this paper
• Immunosenescence.

  1998cited by this paper
• Age‐related impaired affinity maturation and differential D‐JH gene usage in human VH6‐expressing B lymphocytes from healthy individuals

  1997cited by this paper
• Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors.

  1997cited by this paper
• Immunosenescence and germinal center reaction

  1997cited by this paper
• In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

  1997cited by this paper
• Stage-specific alterations in murine B lymphopoiesis with age.

  1996cited by this paper
• The Aging Immune System: Primer and Prospectus

  1996cited by this paper
• The role of cellular competition in B cell survival and selection of B cell repertoires

  1995cited by this paper
• Immune senescence: deficiency or dysregulation.

  1995cited by this paper
• Increase of cross(auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study.

  1994cited by this paper
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  1993cited by this paper
• Immune senescence: mechanisms and clinical implications.

  1992cited by this paper
• Host resistance and the immune system.

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  1992cited by this paper
• Immunodeficiency with hyper-IgM (HIM).

  1992cited by this paper
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  1991cited by this paper
• B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro.

  1991cited by this paper
• Most peripheral B cells in mice are ligand selected

  1991cited by this paper
• Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.

  1989cited by this paper
• The frequency and fine specificity of B cells responsive to (4-hydroxy-3-nitrophenyl)acetyl in aged mice.

  1986cited by this paper
• The Specificity Repertoire of Prereceptor and Mature B Cells a

  1983cited by this paper
• Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. II. Short- and long-term effects of natural infection with parainfluenza type 1 virus (Sendai).

  1979cited by this paper

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