Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biochemical Pharmacology

• Publication date

  2013-12-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.bcp.2013.10.008PMID 24144633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-term methylglyoxal treatment causes endothelial dysfunction of rat isolated mesenteric artery.

  2013cited by this paper
• Carbonyl stress induces hypertension and cardio–renal vascular injury in Dahl salt-sensitive rats

  2013cited by this paper
• Tetrahydrobiopterin in nitric oxide synthase

  2013cited by this paper
• Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases

  2013cited by this paper
• ICAM-1-mediated leukocyte adhesion is critical for the activation of endothelial LSP1.

  2013cited by this paper
• CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis.

  2013cited by this paper
• Activation of AMP-activated protein kinase alleviates high-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics.

  2012cited by this paper
• Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion--a novel role of Nox1.

  2012cited by this paper
• Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

  2012cited by this paper
• Postprandial hyperglycemia and endothelial function in type 2 diabetes: focus on mitiglinide

  2012cited by this paper
• Protein Kinase Cβ Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor–Induced Permeability In Vivo

  2012cited by this paper
• The role of endothelial cell adhesion molecules P‐selectin, E‐selectin and intercellular adhesion molecule‐1 in leucocyte recruitment induced by exogenous methylglyoxal

  2012cited by this paper
• Inhibition of nitric oxide synthesis enhances leukocyte rolling and adhesion in human microvasculature

  2012cited by this paper
• Inflammation in Atherosclerosis

  2012cited by this paper
• Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.

  2012cited by this paper
• Aldolase B Knockdown Prevents High Glucose-Induced Methylglyoxal Overproduction and Cellular Dysfunction in Endothelial Cells

  2012cited by this paper
• Different microvascular permeability responses elicited by the CXC chemokines MIP-2 and KC during leukocyte recruitment: role of LSP1.

  2012cited by this paper
• MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability

  2012cited by this paper
• Reactive oxygen species and endothelial function--role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases.

  2012cited by this paper
• Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling*

  2012cited by this paper
• Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice.

  2012cited by this paper
• Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats

  2012cited by this paper
• Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidant Stress and Increase Nitric Oxide That Increases Blood Flow Recovery after Hindlimb Ischemia in the Rat

  2012cited by this paper
• Methylglyoxal induces hyperpermeability of the blood–retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases

  2012cited by this paper
• Metanx Alleviates Multiple Manifestations of Peripheral Neuropathy and Increases Intraepidermal Nerve Fiber Density in Zucker Diabetic Fatty Rats

  2012cited by this paper
• RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response

  2012cited by this paper
• Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo.

  2011cited by this paper
• Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes

  2011cited by this paper
• Human Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activation

  2011cited by this paper
• Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

  2011cited by this paper
• Inhibitory Effect of Delphinidin on Monocyte–Endothelial Cell Adhesion Induced by Oxidized Low-Density Lipoprotein via ROS/p38MAPK/NF-κB Pathway

  2011cited by this paper
• Tracking neutrophil intraluminal crawling, transendothelial migration and chemotaxis in tissue by intravital video microscopy.

  2011cited by this paper
• HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells

  2011cited by this paper
• Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

  2011cited by this paper
• Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38.

  2010cited by this paper
• The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

  2010cited by this paper
• Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

  2010cited by this paper
• Interaction of Methylglyoxal and Hydrogen Sulfide in Rat Vascular Smooth Muscle Cells

  2010cited by this paper
• Alagebrium attenuates acute methylglyoxal‐induced glucose intolerance in Sprague‐Dawley rats

  2010cited by this paper
• Oxidative stress and aging: is methylglyoxal the hidden enemy?

  2010cited by this paper
• Methylglyoxal induced activation of murine peritoneal macrophages and surface markers of T lymphocytes in sarcoma-180 bearing mice: involvement of MAP kinase, NF-kappa beta signal transduction pathway.

  2009cited by this paper
• eNOS uncoupling and endothelial dysfunction in aged vessels.

  2009cited by this paper
• Evidence for Increased Methylglyoxal in the Vasculature of Women With Preeclampsia: Role in Upregulation of LOX-1 and Arginase

  2009cited by this paper
• Methylglyoxal: possible link between hyperglycaemia and immune suppression?

  2009cited by this paper
• Methylglyoxal modulates immune responses: relevance to diabetes

  2009cited by this paper
• Effect of glucose degradation products, glucose-containing dialysate and icodextrin on AQP1 and eNOS expression in cultured endothelial cells.

  2009cited by this paper
• Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells.

  2009cited by this paper
• Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

  2009cited by this paper
• Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats

  2008cited by this paper
• Glyoxal causes inflammatory injury in human vascular endothelial cells.

  2008cited by this paper
• Methylglyoxal and high glucose co‐treatment induces apoptosis or necrosis in human umbilical vein endothelial cells

  2008cited by this paper
• Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons.

  2008cited by this paper
• The endothelium and vascular inflammation in diabetes

  2007cited by this paper
• A Role for the Endothelial Glycocalyx in Regulating Microvascular Permeability in Diabetes Mellitus

  2007cited by this paper
• Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes

  2007cited by this paper
• AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation.

  2007cited by this paper
• Microvascular Permeability in Diabetes and Insulin Resistance

  2007cited by this paper
• Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase.

  2006cited by this paper
• Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.

  2006cited by this paper
• Critical Role of Methylglyoxal and AGE in Mycobacteria-Induced Macrophage Apoptosis and Activation

  2006cited by this paper
• eNOS Gene Therapy Exacerbates Hepatic Ischemia–Reperfusion Injury in Diabetes: A Role for eNOS Uncoupling

  2006cited by this paper
• The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis

  2006cited by this paper
• Stimulation of Suicidal Erythrocyte Death by Methylglyoxal

  2006cited by this paper
• HIGH GLUCOSE‐INDUCED HUMAN UMBILICAL VEIN ENDOTHELIAL CELL HYPERPERMEABILITY IS DEPENDENT ON PROTEIN KINASE C ACTIVATION AND INDEPENDENT OF THE Ca2+–NITRIC OXIDE SIGNALLING PATHWAY

  2005cited by this paper
• Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

  2005cited by this paper
• Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography.

  2005cited by this paper
• NF-&kgr;B Activation Plays a Role in Superoxide-Mediated Cerebral Endothelial Dysfunction After Hypoxia/Reoxygenation

  2005cited by this paper
• LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration

  2005cited by this paper
• Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.

  2005cited by this paper
• Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation

  2005cited by this paper
• Methylglyoxal: a stimulus to neutrophil oxygen radical production in chronic renal failure?

  2004cited by this paper
• Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells.

  2004cited by this paper
• Superoxide Dismutase Inhibits the Expression of Vascular Cell Adhesion Molecule-1 and Intracellular Cell Adhesion Molecule-1 Induced by Tumor Necrosis Factor-&agr; in Human Endothelial Cells Through the JNK/p38 Pathways

  2004cited by this paper
• S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity.

  2004cited by this paper
• Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion.

  2004cited by this paper
• Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process.

  2004cited by this paper
• Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.

  2003cited by this paper
• Pathophysiological implications of insulin resistance on vascular endothelial function

  2003cited by this paper
• Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

  2003cited by this paper
• Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal.

  2003cited by this paper
• Production of Sepiapterin in Escherichia coli by Coexpression of Cyanobacterial GTP Cyclohydrolase I and Human 6-Pyruvoyltetrahydropterin Synthase

  2002cited by this paper
• Reactive oxygen species mediate leukocyte-endothelium interactions in prostaglandin F2alpha -induced luteolysis in rats.

  2002cited by this paper
• Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation.

  2002cited by this paper
• Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells.

  2002cited by this paper
• The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide*

  2001cited by this paper
• Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: studies in iNOS-deficient mice.

  2001cited by this paper
• Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase.

  2000cited by this paper
• Enzymatic function of nitric oxide synthases.

  1999cited by this paper
• Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation.

  1999cited by this paper
• Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

  1996cited by this paper
• Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase.

  1993cited by this paper
• Modification of the glyoxalase system in streptozotocin-induced diabetic rats. Effect of the aldose reductase inhibitor Statil.

  1993cited by this paper
• Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation.

  1993cited by this paper
• O R I G I N a L I N V E S T I G a T I O N Open Access

  year unknowncited by this paper

• Immunosenescence‐Driven Hemodynamic Dysregulation and Cognitive Impairment in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Integrative Perspective

  2026cites this paper
• Are You a Friend or an Enemy? The Dual Action of Methylglyoxal on Brain Microvascular Endothelial Cells

  2025cites this paper
• Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study

  2025cites this paper
• Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

  2023cites this paper
• Immunometabolism and the modulation of immune responses and host defense: A role for methylglyoxal?

  2022cites this paper
• Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.

  2021cites this paper
• Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?

  2020cites this paper
• Critical role for PI3Kγ‐dependent neutrophil reactive oxygen species in WKYMVm‐induced microvascular hyperpermeability

  2019cites this paper
• Metabolic Pathways Fueling the Endothelial Cell Drive.

  2019cites this paper
• Endothelial Cell Metabolism.

  2018cites this paper
• miR-590-3p mediates the protective effect of curcumin on injured endothelial cells induced by angiotensin II.

  2017cites this paper
• The Link Between Angiogenesis and Endothelial Metabolism.

  2017cites this paper
• Metabolic Regulation of Angiogenesis in Diabetes and Aging.

  2017cites this paper
• Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

  2017cites this paper
• Signal and regulatory effects of methylglyoxal in eukaryotic cells (review)

  2017cites this paper
• Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

  2017cites this paper
• Metabolic adaptations in diabetic endothelial cells.

  2015cites this paper
• Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling.

  2014cites this paper
• Mechanisms of Methylglyoxal-elicited Leukocyte Recruitment

  2014influential citation
• Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal

  2014cites this paper
• Nitric Oxide Synthase Promotes Distension-Induced Tracheal Venular Leukocyte Adherence

  2014cites this paper