Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Brain Research

• Publication date

  1997-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0006-8993(96)01262-0PMID 9037507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

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• Degradation of Amyloid -Protein by a Serine Protease--Macroglobulin Complex (*)

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Zinc and Alzheimer's disease.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Amyloid beta protein 1-42/43 (A beta 1-42/43) in cerebellar diffuse plaques: enzyme-linked immunosorbent assay and immunocytochemical study.

  1995cited by this paper
• Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

  1994cited by this paper
• Prion diseases and neurodegeneration.

  1994cited by this paper
• Rapid induction of Alzheimer A beta amyloid formation by zinc.

  1994cited by this paper
• The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.

  1994cited by this paper
• An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

  1994cited by this paper
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  1994cited by this paper
• Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease.

  1994cited by this paper
• Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.

  1994cited by this paper
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  1994cited by this paper
• Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid

  1993cited by this paper
• Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

  1993cited by this paper
• Processing of the beta-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments.

  1993cited by this paper
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  1993cited by this paper
• Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

  1993cited by this paper
• Characterization of beta-amyloid peptide from human cerebrospinal fluid.

  1993cited by this paper
• Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

  1993cited by this paper
• Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.

  1993cited by this paper
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  1993cited by this paper
• Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

  1992cited by this paper
• Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

  1992cited by this paper
• Amyloid beta/A4 precursor protein (APP) processing in lysosomes.

  1992cited by this paper
• In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity ☆

  1991cited by this paper
• In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity.

  1991cited by this paper
• pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells

  1991cited by this paper
• Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

  1990cited by this paper
• Beta-amyloid protein promotes neuritic branching in hippocampal cultures.

  1990cited by this paper
• Evidence for lysosomal processing of amyloid β-protein precursor in cultured cells

  1989cited by this paper
• The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects.

  1989cited by this paper
• Amyloid beta protein enhances the survival of hippocampal neurons in vitro.

  1989cited by this paper
• Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

  1989cited by this paper
• Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

  1988cited by this paper
• A microsystem to assay lysosomal enzyme activities in cultured retinal pigment epithelial cells.

  1988cited by this paper
• Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

  1988cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1971cited by this paper
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  1969cited by this paper
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  1844cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2021cites this paper
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  2020cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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