Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Cancer Research

• Publication date

  2017-12-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-17-0404PMID 29233910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016influential reference
• Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer

  2016cited by this paper
• Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial.

  2016cited by this paper
• Association between molecular subtypes of colorectal cancer and patient survival.

  2015cited by this paper
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  2015cited by this paper
• Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

  2015cited by this paper
• Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.

  2015cited by this paper
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  2015cited by this paper
• Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
• Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma.

  2015cited by this paper
• The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.

  2014influential reference
• Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.

  2014cited by this paper
• ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

  2014cited by this paper
• Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy.

  2014cited by this paper
• High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients

  2014cited by this paper
• Sequential Cdk1 and Plk1 phosphorylation of caspase‐8 triggers apoptotic cell death during mitosis

  2014cited by this paper
• Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma.

  2013cited by this paper
• Bcl-2/Bcl-xL Inhibition Increases the Efficacy of MEK Inhibition Alone and in Combination with PI3 Kinase Inhibition in Lung and Pancreatic Tumor Models

  2013cited by this paper
• Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012. (5)

  2013cited by this paper
• Comprehensive molecular characterization of human colon and rectal cancer

  2012cited by this paper
• Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.

  2011cited by this paper
• Improved survival with vemurafenib in melanoma with BRAF V600E mutation.

  2011cited by this paper
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

  2011cited by this paper
• Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011influential reference
• An overview of Cdk1-controlled targets and processes

  2010cited by this paper
• Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

  2010cited by this paper
• Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

  2010influential reference
• COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation

  2010cited by this paper
• Cell cycle: Activities of a mitotic master

  2010cited by this paper
• Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.

  2010cited by this paper
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  2010cited by this paper
• BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

  2009cited by this paper
• Life and death by death receptors

  2009cited by this paper
• Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules

  2009cited by this paper
• BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells.

  2008cited by this paper
• Cdk1 is sufficient to drive the mammalian cell cycle

  2007cited by this paper
• Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis.

  2007cited by this paper
• Distinct sets of genetic alterations in melanoma.

  2005cited by this paper
• Cyclin D-dependent kinases, INK4 inhibitors and cancer.

  2002cited by this paper
• Mutations of the BRAF gene in human cancer

  2002cited by this paper

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  2025cites this paper
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  2025cites this paper
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