The structural requirements of sterols for membrane function in Saccharomyces cerevisiae.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Archives of Biochemistry and Biophysics

• Publication date

  1993-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/ABBI.1993.1100PMID 8434952
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence for facilitated transport in the absorption of sterols bySaccharomyces cerevisiae

  2006cited by this paper
• Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase.

  1991cited by this paper
• Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae

  1989cited by this paper
• Inhibition of sterol synthesis by delta 5-sterols in a sterol auxotroph of yeast defective in oxidosqualene cyclase and cytochrome P-450.

  1988cited by this paper
• Conformational analysis of 9beta,19-cyclopropyl sterols: Detection of the pseudoplanar conformer by nuclear Overhauser effects and its functional implications.

  1988cited by this paper
• Biosynthesis of cholesterol in the yeast mutant erg6.

  1988cited by this paper
• Comparison of the chromatographic properties of sterols, select additional steroids and triterpenoids: gravity-flow column liquid chromatography, thin-layer chromatography, gas-liquid chromatography and high-performance liquid chromatography.

  1988cited by this paper
• Prokaryotic hopanoids and other polyterpenoid sterol surrogates.

  1987cited by this paper
• Multiple functions for sterols in Saccharomyces cerevisiae.

  1985cited by this paper
• Stereochemical specificity for sterols in Saccharomyces cerevisiae.

  1983cited by this paper
• Sterol synergism in yeast.

  1983cited by this paper
• Stereochemically distinct roles for sterol in Saccharomyces cerevisiae.

  1983cited by this paper
• Sterol structure and membrane function.

  1983cited by this paper
• Structural and physiological features of sterols necessary to satisfy bulk membrane and sparking requirements in yeast sterol auxotrophs.

  1983cited by this paper
• A requirement for ergosterol to permit growth of yeast sterol auxotrophs on cholestanol.

  1982cited by this paper
• Utilization and metabolism of methyl-sterol derivatives in the yeast mutant strain GL7.

  1981cited by this paper
• Effect of sterol side chains on growth and membrane fatty acid composition of Saccharomyces cerevisiae

  1980cited by this paper
• Comparative responses of the yeast mutant strain GL7 to lanosterol, cycloartenol, and cyclolaudenol.

  1980cited by this paper
• Effects of cycloartenol and lanosterol on artificial and natural membranes.

  1980cited by this paper
• The functional importance of structural features of ergosterol in yeast.

  1978cited by this paper
• Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.

  1977cited by this paper
• Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high-pressure liquid chromatography.

  1977cited by this paper
• Discrimination between cholesterol and ergosterol by yeast membranes.

  1976cited by this paper
• The function of sterols in membranes.

  1976cited by this paper

• Lipid droplets control the negative effect of non-yeast sterols in membranes of Saccharomyces cerevisiae under hypoxic stress.

  2024cites this paper
• Therapeutic Updates on the Management of Tinea Corporis or Cruris in the Era of Trichophyton Indotineae: Separating Evidence from Hype—A Narrative Review

  2023cites this paper
• Novel sterol binding domains in bacteria

  2023cites this paper
• The evolution of anaerobic growth in Saccharomycotina yeasts

  2023cites this paper
• Superficial Dermatophytosis across the World’s Populations: Potential Benefits from Nanocarrier-Based Therapies and Rising Challenges

  2023cites this paper
• Unearthing the Janus-face cholesterogenesis pathways in cancer.

  2021cites this paper
• Squalene-Tetrahymanol Cyclase Expression Enables Sterol-Independent Growth of Saccharomyces cerevisiae

  2020cites this paper
• Validation of carbon isotope fractionation in algal lipids as a pCO2 proxy using a natural CO2 seep (Shikine Island, Japan)

  2019cites this paper
• Carbohydrate hitched imidazoles as agents for the disruption of fungal cell membrane.

  2019cites this paper
• Antifungal resistance in dermatophytes: recent trends and therapeutic implications.

  2019cites this paper
• Classification: Biological Sciences, Biochemistry 1 Functional Importance for Developmental Regulation of Sterol Biosynthesis in 2 Acanthamoeba castellanii 3

  2018influential citation
• Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.

  2018influential citation
• Lanosterol synthase-like is involved with differential accumulation of steroidal glycoalkaloids in potato

  2017cites this paper
• Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development

  2017cites this paper
• Triterpenoid modulates the salt tolerance of lanosterol synthase deficient Saccharomyces cerevisiae, GIL77

  2016cites this paper
• The Mechanistic Targets of Antifungal Agents: An Overview.

  2016cites this paper
• The impact of amino acid availability and gene transcription on aroma compound profiling in Saccharomyces yeast

  2016cites this paper
• A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: comparison with their 5-cholesten analogues.

  2015cites this paper
• Sterol Biosynthesis Inhibitors: C-4 Demethylation

  2015cites this paper
• A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes.

  2015cites this paper
• A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs.

  2015cites this paper
• A distinct pathway for tetrahymanol synthesis in bacteria

  2015cites this paper
• Plant Oxidosqualene Metabolism: Cycloartenol Synthase–Dependent Sterol Biosynthesis in Nicotiana benthamiana

  2014cites this paper
• Plant cyclopropylsterol-cycloisomerase: key amino acids affecting activity and substrate specificity.

  2014cites this paper
• Modulation de l’activité du flavocytochrome b₅₅₈ : étude fonctionnelle

  2014cites this paper
• Molecular Mechanisms in Yeast Carbon Metabolism: Lipid Metabolism and Lipidomics

  2014cites this paper
• Role of sterol 3-ketoreductase sensitivity in susceptibility to the fungicide fenhexamid in Botrytis cinerea and other phytopathogenic fungi.

  2013cites this paper
• Yeast metabolic engineering--targeting sterol metabolism and terpenoid formation.

  2013cites this paper
• Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence.

  2012cites this paper
• Chapter 6 – PLANT GLYCOLIPIDS: STRUCTURE, ISOLATION AND ANALYSIS

  2012cites this paper
• Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism.

  2011cites this paper
• Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis.

  2010cites this paper
• Biochemistry of Alcoholic Fermentation

  2009cites this paper
• Fluconazole modulates membrane rigidity, heterogeneity, and water penetration into the plasma membrane in Saccharomyces cerevisiae.

  2009cites this paper
• The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans.

  2009cites this paper
• Synthesis and turnover of non-polar lipids in yeast.

  2008cites this paper
• Plant Sterol Methyltransferases: Phytosterolomic Analysis, Enzymology, and Bioengineering Strategies

  2008cites this paper
• Chapter nine Engineering pathway enzymes to understand the function and evolution of sterol structure and activity

  2006cites this paper
• Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site.

  2005cites this paper
• The Diversity and Importance of Microbial Cytochromes P450

  2005cites this paper
• Mechanism-based enzyme inactivators of phytosterol biosynthesis.

  2004cites this paper
• 5 Sterol metabolism and functions in higher plants

  2004cites this paper
• References

  2004cites this paper
• Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa.

  2003cites this paper
• 13 – Brewing yeasts

  2003cites this paper
• Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii

  2002cites this paper
• Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis.

  2002cites this paper
• Brewing Yeast and Fermentation

  2001cites this paper
• Terpenoids : Higher

  2001cites this paper
• Structural requirements for substrate recognition of Mycobacterium tuberculosis 14 alpha-demethylase: implications for sterol biosynthesis.

  2001influential citation
• Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces cerevisiae.

  2001cites this paper
• The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).

  2001cites this paper
• Effects of singlet oxygen on membrane sterols in the yeast Saccharomyces cerevisiae.

  2000cites this paper
• Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition.

  2000cites this paper
• Functional Cloning of an Arabidopsis thalianacDNA Encoding Cycloeucalenol Cycloisomerase*

  2000cites this paper
• Sterol methyl transferase: enzymology and inhibition.

  2000cites this paper
• Sterol methyl transferase: enzymology and inhibition.

  2000cites this paper
• Inhibitors of CYP51 As Antifungal Agents and Resistance to Azole Antifungals

  1999cites this paper
• Molecular and biochemical mechanisms of drug resistance in fungi.

  1999cites this paper
• Specific sterols required for the internalization step of endocytosis in yeast.

  1999cites this paper
• Mechanisms of Resistance to Fenpropimorph and Terbinafine, Two Sterol Biosynthesis Inhibitors, in Nectria haematococca, a Phytopathogenic Fungus

  1999cites this paper
• Characterization by gas chromatography/mass spectrometry of sterols in saccharomyces cerevisiae during autolysis.

  1999cites this paper
• Systemic antifungal agents against AIDS-related opportunistic infections: current status and emerging drugs in development.

  1999cites this paper
• Enhanced sterol-acyl transferase activity promotes sterol accumulation in Saccharomyces cerevisiae

  1999cites this paper
• Molecular aspects of azole antifungal action and resistance.

  1999cites this paper
• Biotransformation of 24 alpha-methylcholesterol and 24 beta-methylcholesterol by yeast mutant GL7.

  1999cites this paper
• Biotransformation of 24α-Methylcholesterol and 24β-Methylcholesterol by Yeast Mutant GL7

  1999cites this paper
• Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.

  1999cites this paper
• Plant sterols and the membrane environment

  1998cites this paper
• The biosynthesis of steroids and triterpenoids

  1998cites this paper
• Plant sterols and the membrane

  1998cites this paper
• Effects of sterol biosynthesis inhibitor fungicides in the phytopathogenic fungus, Nectria haematococca: ergosterol depletion versus precursor or abnormal sterol accumulation as the mechanism of fungitoxicity

  1998cites this paper
• Extraction of sterols from tissues

  1997cites this paper
• Substrate-Based Inhibitors of the (S)-Adenosyl-l-Methionine:Δ24(25)- to Δ24(28)-Sterol Methyl Transferase fromSaccharomyces cerevisiae ☆ ☆☆

  1997cites this paper
• Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors.

  1997cites this paper
• Fungicides as Tools in Studying Postsqualene Sterol Synthesis in Plants

  1997cites this paper
• Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae

  1997cites this paper
• Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae.

  1997cites this paper
• S Saccharomyces cerevisiae .-independent glycerol transport in Characteristics of Fps 1-dependent and

  1997cites this paper
• In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei.

  1997cites this paper
• Molecular mechanisms of azole resistance in fungi.

  1997cites this paper
• Antifungal sterol biosynthesis inhibitors.

  1997cites this paper
• UDP-glucose:sterol glucosyltransferase: cloning and functional expression in Escherichia coli/

  1997cites this paper
• A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.

  1997cites this paper
• Resistance to Antifungal Azoles inUstilago maydisthrough Alteration of Sterol Δ5(6)Desaturase

  1996cites this paper
• Mechanistic and Metabolic Studies of Sterol 24,25-Double Bond Reduction in Manduca sexta

  1996cites this paper
• Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes

  1996cites this paper
• Review of progress in sterol oxidations: 1987–1995

  1996cites this paper
• Investigation of the Sterol Composition and Azole Resistance in Field Isolates of Septoria tritici

  1996cites this paper
• Biochemistry and Molecular Biology of Fungal Sterols

  1996cites this paper
• Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae.

  1996cites this paper
• Stereochemistry of hydrogen migration from C-24 to C-25 during biomethylation in ergosterol biosynthesis

  1996cites this paper
• Antifungal agents: chemotherapeutic targets and immunologic strategies

  1996cites this paper
• Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance

  1996cites this paper
• The plasma membrane of Saccharomyces cerevisiae: structure, function, and biogenesis.

  1995influential citation
• Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients

  1995cites this paper
• Developmental regulation of sterol biosynthesis inZea mays

  1995cites this paper
• Cross-resistance to polyene and azole drugs in Cryptococcus neoformans

  1995cites this paper
• Developmental differences in the sterol composition of Solenopsis invicta

  1995cites this paper
• Defective sterol Δ5(6)desaturase as a cause of azole resistance in Ustilago maydis

  1995cites this paper