Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Experimental Neurology

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine, Chemistry, Computer Science

• Identifiers
  DOI 10.1016/j.expneurol.2016.05.037PMID 27246997PMCID PMC5681703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activity-dependent synaptic plasticity modulates the critical phase of brain development.

  2016cited by this paper
• Pharmacological considerations in the use of stiripentol for the treatment of epilepsy

  2016cited by this paper
• Computational models of epileptiform activity.

  2016cited by this paper
• Interneuron activity leads to initiation of low‐voltage fast‐onset seizures

  2015cited by this paper
• Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

  2015cited by this paper
• Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

  2014cited by this paper
• Benzodiazepines

  2014cited by this paper
• Untangling the Dravet Syndrome Seizure Network: The Changing Face of a Rare Genetic Epilepsy

  2014cited by this paper
• Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

  2014cited by this paper
• A variant of KCC2 from patients with febrile seizures impairs neuronal Cl− extrusion and dendritic spine formation

  2014influential reference
• Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

  2014cited by this paper
• Equalizing Excitation-Inhibition Ratios across Visual Cortical Neurons

  2014cited by this paper
• On the nature of seizure dynamics.

  2014cited by this paper
• Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence.

  2014cited by this paper
• Dravet syndrome (severe myoclonic epilepsy in infancy).

  2013cited by this paper
• Shape features of epileptic spikes are a marker of epileptogenesis in mice

  2013cited by this paper
• Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons.

  2013cited by this paper
• Dravet syndrome patient‐derived neurons suggest a novel epilepsy mechanism

  2013cited by this paper
• Pharmacodynamic interaction between stiripentol and benzodiazepines: from molecular to clinical studies.

  2013cited by this paper
• EEG and MEG: relevance to neuroscience.

  2013cited by this paper
• Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

  2013cited by this paper
• Transition to Seizure: Ictal Discharge Is Preceded by Exhausted Presynaptic GABA Release in the Hippocampal CA3 Region

  2012cited by this paper
• Pyramidal cells accumulate chloride at seizure onset.

  2012cited by this paper
• Electroencephalographic Features in Dravet Syndrome

  2012cited by this paper
• Fast synaptic inhibition in spinal sensory processing and pain control.

  2012cited by this paper
• Autistic behavior in Scn1a+/− mice and rescue by enhanced GABAergic transmission

  2012cited by this paper
• N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl− Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain*

  2012cited by this paper
• Interictal spikes, fast ripples and seizures in partial epilepsies – combining multi‐level computational models with experimental data

  2012cited by this paper
• The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders

  2012cited by this paper
• Stiripentol

  2012cited by this paper
• Recording of fast activity at the onset of partial seizures: Depth EEG vs. scalp EEG

  2012cited by this paper
• Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

  2012cited by this paper
• Diagnosis and long-term course of Dravet syndrome.

  2012cited by this paper
• Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

  2012cited by this paper
• Electroencephalographic characteristics of Dravet syndrome

  2011cited by this paper
• NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor mediated currents

  2011cited by this paper
• Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

  2011cited by this paper
• Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines.

  2011cited by this paper
• Intermittent spike-wave dynamics in a heterogeneous, spatially extended neural mass model

  2011cited by this paper
• Altered GABA Signaling in Early Life Epilepsies

  2011cited by this paper
• Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: A prospective pilot study

  2011cited by this paper
• The genetics of Dravet syndrome

  2011influential reference
• Computational modeling of high-frequency oscillations at the onset of neocortical partial seizures: From 'altered structure' to 'dysfunction'

  2010influential reference
• Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome

  2010cited by this paper
• Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down’s syndrome

  2010cited by this paper
• Activity‐dependent intracellular chloride accumulation and diffusion controls GABAA receptor‐mediated synaptic transmission

  2010cited by this paper
• Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges

  2009cited by this paper
• Epileptogenesis in the immature brain: emerging mechanisms

  2009influential reference
• Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis

  2009cited by this paper
• Cation-chloride cotransporters and neuronal function.

  2009cited by this paper
• Synaptic Cross Talk between Perisomatic-Targeting Interneuron Classes Expressing Cholecystokinin and Parvalbumin in Hippocampus

  2009cited by this paper
• An unexpected EEG course in Dravet syndrome.

  2008cited by this paper
• Epilepsy, E/I Balance and GABAA Receptor Plasticity

  2008cited by this paper
• Severe myoclonic epilepsy in infancy: A systematic review and a meta‐analysis of individual patient data

  2008cited by this paper
• Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

  2008cited by this paper
• The spectrum of SCN1A-related infantile epileptic encephalopathies.

  2007cited by this paper
• Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks

  2007cited by this paper
• GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.

  2007cited by this paper
• Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy

  2007cited by this paper
• Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy

  2007influential reference
• An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy

  2007cited by this paper
• A Brief Period of Epileptiform Activity Strengthens Excitatory Synapses in the Rat Hippocampus in Vitro

  2006cited by this paper
• Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.

  2006cited by this paper
• Stiripentol, a Putative Antiepileptic Drug, Enhances the Duration of Opening of GABAA‐Receptor Channels

  2006influential reference
• Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

  2006influential reference
• Slow endogenous activity transients and developmental expression of K+–Cl− cotransporter 2 in the immature human cortex

  2005influential reference
• NKCC1 transporter facilitates seizures in the developing brain

  2005cited by this paper
• Trophic actions of GABA on neuronal development.

  2005cited by this paper
• Use-dependent shift from inhibitory to excitatory GABAA receptor action in SP-O interneurons in the rat hippocampal CA3 area.

  2003cited by this paper
• Effects of Antiepileptic Drugs on Refractory Seizures in the Intact Immature Corticohippocampal Formation In Vitro

  2003cited by this paper
• Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial.

  2002cited by this paper
• Is there more to gaba than synaptic inhibition?

  2002cited by this paper
• Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

  2002influential reference
• New concepts in neonatal seizures.

  2002cited by this paper
• De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy.

  2001influential reference
• Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial

  2000influential reference
• Cell type‐ and synapse‐specific variability in synaptic GABAA receptor occupancy

  2000cited by this paper
• Brain chirps: spectrographic signatures of epileptic seizures.

  2000cited by this paper
• Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2

  2000cited by this paper
• Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group.

  2000influential reference
• Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes.

  1997cited by this paper
• Long-Lasting GABA-Mediated Depolarization Evoked by High-Frequency Stimulation in Pyramidal Neurons of Rat Hippocampal Slice Is Attributable to a Network-Driven, Bicarbonate-Dependent K+ Transient

  1997cited by this paper
• Benzodiazepine and beta‐carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

  1994cited by this paper
• Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines.

  1992cited by this paper
• Electroencephalography. Basic principles, clinical applications and related fields

  1982influential reference
• This Work Is Licensed under a Creative Commons Attribution 4.0 International License Date Deposited: the Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity

  year unknowncited by this paper

• Ripple-Spikes Localize the Epileptogenic Zone and Its Interpretation: Integrating Data-Driven and Model-Driven Methods

  2025cites this paper
• Personalized whole-brain models of seizure propagation

  2025cites this paper
• Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy

  2025cites this paper
• Modelling dysfunction-specific interventions for seizure termination in epilepsy

  2025cites this paper
• Long-term Effect of Multichannel tDCS Protocol in Patients with Central Cortex Epilepsies Associated with Epilepsia Partialis Continua

  2024cites this paper
• Transition to seizure in focal epilepsy: From SEEG phenomenology to underlying mechanisms

  2024cites this paper
• Expansion of epileptogenic networks via neuroplasticity in neural mass models

  2024cites this paper
• Localization of the epileptogenic network from scalp EEG using a patient-specific whole-brain model

  2024cites this paper
• Ictal-Related Chirp as a Biomarker for Monitoring Seizure Progression

  2024influential citation
• An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome

  2023cites this paper
• Using compartmental models to understand excitation-inhibition imbalance in epilepsy

  2023cites this paper
• Exploration of interictal to ictal transition in epileptic seizures using a neural mass model

  2023cites this paper
• Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing γ‐aminobutyric acid as a common mechanism

  2023cites this paper
• GABAA signaling, focal epileptiform synchronization and epileptogenesis

  2022cites this paper
• Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

  2021cites this paper
• In silico model reveals the key role of GABA in KCNT1‐epilepsy in infancy with migrating focal seizures

  2021cites this paper
• Long term evolution of fast ripples during epileptogenesis

  2021cites this paper
• Anticonvulsant Agents: Stiripentol

  2021cites this paper
• Non-monotonic effects of GABAergic synaptic inputs on neuronal firing

  2021cites this paper
• A personalizable autonomous neural mass model of epileptic seizures

  2021influential citation
• A methodological framework for drug development in rare diseases. The CRESim program: Epilogue and perspectives.

  2020cites this paper
• Clinical Drivers for Personalization of Transcranial Current Stimulation (tES 3.0)

  2020cites this paper
• A Novel Recognition Strategy for Epilepsy EEG Signals Based on Conditional Entropy of Ordinal Patterns

  2020cites this paper
• Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences

  2020cites this paper
• Modelling acute and lasting effects of tDCS on epileptic activity

  2020cites this paper
• Assessing drug response in engineered brain microenvironments.

  2019influential citation
• Small changes in synaptic gain lead to seizure-like activity in neuronal network at criticality

  2019cites this paper
• GABAA receptor-mediated networks during focal seizure onset and progression in vitro.

  2019cites this paper
• Cefepime‐induced encephalopathy: Neural mass modeling of triphasic wave‐like generalized periodic discharges with a high negative component (Tri‐HNC)

  2018cites this paper
• On the origin of epileptic High Frequency Oscillations observed on clinical electrodes.

  2018cites this paper
• Personalization of hybrid brain models from neuroimaging and electrophysiology data

  2018cites this paper
• Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures

  2018cites this paper
• From molecules to medicines: the dawn of targeted therapies for genetic epilepsies

  2018cites this paper
• Computational model of interictal discharges triggered by interneurons

  2017cites this paper
• Pharmacogenomics in epilepsy

  2017cites this paper
• Treatment of Epileptic Encephalopathies.

  2017cites this paper