A novel agonist binding site on nicotinic acetylcholine receptors.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Receptor Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3109/10799899309073670PMID 8450498
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physostigmine and Neuromuscular Transmission a

  1993cited by this paper
• Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.

  1992cited by this paper
• Functional properties of the nicotinic and glutamatergic receptors.

  1991cited by this paper
• A second pathway of activation of the Torpedo acetylcholine receptor channel.

  1991cited by this paper
• Desensitization is a property of the cholinergic binding region of the nicotinic acetylcholine receptor, not of the receptor‐integral ion channel

  1991cited by this paper
• Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons.

  1991cited by this paper
• A novel type of nicotinic receptor in the rat central nervous system characterized by patch-clamp techniques

  1990cited by this paper
• A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX.

  1990cited by this paper
• The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels.

  1990cited by this paper
• alpha-Cobratoxin blocks the nicotinic acetylcholine receptor in rat hippocampal neurons.

  1990cited by this paper
• The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4

  1989cited by this paper
• Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

  1989cited by this paper
• Regulating the number and function of neuronal acetylcholine receptors.

  1989cited by this paper
• The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4.

  1989cited by this paper
• Macromolecular sites for specific neurotoxins and drugs on chemosensitive synapses and electrical excitation in biological membranes.

  1988cited by this paper
• Methyllycaconitine and (+)‐anatoxin‐a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems

  1988cited by this paper
• Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site.

  1988cited by this paper
• Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex.

  1988cited by this paper
• Photoaffinity labeling of the acetylcholine binding sites on the nicotinic receptor by an aryldiazonium derivative.

  1988cited by this paper
• Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.

  1987cited by this paper
• Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

  1987cited by this paper
• The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

  1987cited by this paper
• Nicotinic acetylcholine receptors in cultured neurons from the hippocampus and brain stem of the rat characterized by single channel recording

  1987cited by this paper
• Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells

  1987cited by this paper
• Purification and characterization of a nicotinic acetylcholine receptor from rat brain.

  1987cited by this paper
• Activation and Blockade of the Nicotinic and Glutamatergic Synapses by Reversible and Irreversible Cholinesterase Inhibitors

  1987cited by this paper
• Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

  1986cited by this paper
• Effectiveness of Physostigmine as a Pretreatment Drug for Protection of Rats from Organophosphate Poisoning

  1986cited by this paper
• Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning.

  1986cited by this paper
• Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a.

  1986cited by this paper
• Analysis of ligand binding to the synthetic dodecapeptide 185-196 of the acetylcholine receptor alpha subunit.

  1986cited by this paper
• The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

  1985cited by this paper
• Comparison of the actions of carbamate anticholinesterases on the nicotinic acetylcholine receptor.

  1985cited by this paper
• Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.

  1985cited by this paper
• The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies.

  1984cited by this paper
• Interactions of bupivacaine with ionic channels of the nicotinic receptor. Analysis of single-channel currents.

  1984cited by this paper
• The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex

  1984cited by this paper
• The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex.

  1984cited by this paper
• Molecular modifications and modulation of adverse actions of muscle relaxants in anesthesiology.

  1984cited by this paper
• Oral physostigmine and lecithin improve memory in Alzheimer disease

  1983cited by this paper
• Potencies and channel properties induced by semirigid agonists at frog nicotinic acetylcholine receptors.

  1983cited by this paper
• The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics.

  1983cited by this paper
• Alcohol modulation of drug binding to the channel sites of the nicotinic acetylcholine receptor.

  1983cited by this paper
• The automated analysis of data from single ionic channels

  1982cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor.

  1981cited by this paper
• Sites of action of phencyclidine. II. Interaction with the ionic channel of the nicotinic receptor.

  1980cited by this paper
• The principal toxin ofDelphinium brownii Rydb., and its mode of action

  1979cited by this paper
• Differential effect of perhydrohistrionicotoxin on ‘intrinsic’ and ‘extrinsic’ end‐plate responses.

  1979cited by this paper
• Kinetic analysis of end plate currents altered by atropine and scopolamine.

  1978cited by this paper
• Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

  1978cited by this paper
• The protection of animals against organophosphate poisoning by pretreatment with a carbamate.

  1978cited by this paper
• Acetylcholine receptor. Responses to drug binding.

  1977cited by this paper
• Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.

  1974cited by this paper
• The density of acetylcholine receptors and their sensitivity in the postsynaptic membrane of muscle endplates.

  1974cited by this paper

• Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors

  2018cites this paper
• Antidiabetic effects of polyacetylenes and related compounds

  2017cites this paper
• Aalborg Universitet Application of chemometric methods in processing of natural products

  2017cites this paper
• Application of chemometric methods in processing of natural products: Case study of artemisinin from Artemisia annua

  2017cites this paper
• Polyacetylenes of the falcarinol type: A promising new class of nutraceuticals and lead compounds for the development of anticancer drugs

  2017cites this paper
• Dietary polyacetylenes, falcarinol and falcarindiol, prevents the formation of neoplastic lesions in the colon of azoxymethaneinduced rats

  2017cites this paper
• Harvest strategies of aerial parts and roots of Echinacea purpurea for high contentof bioactive compounds

  2017cites this paper
• Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease.

  2013cites this paper
• Methylene blue inhibits the function of α7-nicotinic acetylcholine receptors.

  2012cites this paper
• Calcium signalling mediated through α7 and non‐α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

  2011cites this paper
• Axo‐axonal interaction in autonomic regulation of the cerebral circulation

  2011cites this paper
• A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons

  2011cites this paper
• Upregulation and Functionality of Neuronal Nicotinic Acetylcholine Receptors

  2006cites this paper
• Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor.

  2006cites this paper
• Cholinesterase Inhibitor Blockade and its Prevention by Statins of Sympathetic α7-nAChR-Mediated Cerebral Nitrergic Neurogenic Vasodilation

  2006cites this paper
• Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig.

  2005cites this paper
• Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.

  2005cites this paper
• Galantamine Activates Muscle-Type Nicotinic Acetylcholine Receptors without Binding to the Acetylcholine-Binding Site

  2005cites this paper
• Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs.

  2004cites this paper
• Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs.

  2004cites this paper
• Guinea-pig heart acetylcholinesterase after continuous physostigmine administration

  2003cites this paper
• Neuronal Nicotinic Acetylcholine Receptors in Non-neuronal Cells, Expression and Renaturation of Ligand Binding Domain, and Modulatory Control by Allosterically Acting Ligands

  2000cites this paper
• Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease.

  2000cites this paper
• Exploring the nature of molecular recognition in nicotinic acetylcholine receptors.

  2000cites this paper
• Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease.

  2000cites this paper
• Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors.

  2000cites this paper
• Eserine and other tertiary amine interactions with Torpedo acetylcholine receptor postsynaptic membrane vesicles.

  1999cites this paper
• Physostigmine and acetylcholine differentially activate nicotinic receptor subpopulations in Locusta migratoria neurons.

  1998cites this paper
• The Pharmacology of Physostigmine

  1998cites this paper
• Effects of extracellular acetylcholine on muscarinic receptor binding assessed by [125I]dexetimide and a simple probe.

  1998cites this paper
• Differential effects of physostigmine and organophosphates on nicotinic receptors in neuronal cells of different species.

  1998cites this paper
• Inhibitory effects of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea‐pig adrenal chromaffin cells

  1998cites this paper
• Expression and Renaturation of the N-terminal Extracellular Domain of Torpedo Nicotinic Acetylcholine Receptor α-Subunit*

  1998cites this paper
• Brain nicotinic receptors: structure and regulation, role in learning and reinforcement.

  1998cites this paper
• Nicotinic acetylcholine receptors on hippocampal neurons: distribution on the neuronal surface and modulation of receptor activity.

  1997cites this paper
• The pharmacology of (-)-nicotine and novel cholinergic channel modulators.

  1997cites this paper
• Topology of ligand binding sites on the nicotinic acetylcholine receptor.

  1997cites this paper
• Methamidophos: an anticholinesterase without significant effects on postsynaptic receptors or transmitter release.

  1997cites this paper
• Screening structural-functional relationships of neuropharmacologically active organic compounds at the nicotinic acetylcholine receptor.

  1997cites this paper
• Effects of pyridostingmine on acetylcholinesterase in different muscles of the mouse

  1997cites this paper
• Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function.

  1997cites this paper
• Neuronal nicotinic acetylcholine receptors as targets for drug discovery.

  1997cites this paper
• Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels.

  1997cites this paper
• Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor.

  1996cites this paper
• Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity.

  1996cites this paper
• Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes.

  1996cites this paper
• The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor.

  1996cites this paper
• Nicotinic Receptor Function in the Mammalian Central Nervous System a

  1995cites this paper
• Physostigmine, galanthamine and codeine act as 'noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma cells.

  1995cites this paper
• Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

  1994cites this paper
• Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.

  1994cites this paper
• Identification of purine binding sites on Torpedo acetylcholine receptor.

  1994cites this paper
• Electrophysiological Methods for the Study of Neuronal Nicotinic Acetylcholine Receptor Ion Channels

  1994cites this paper
• Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide.

  1994cites this paper
• Blockade of nicotinic responses by physostigmine, tacrine and other cholinesterase inhibitors in rat striatum

  1994cites this paper
• CHAPTER 18 – Nicotinic Acetylcholine Receptor of the Mammalian Central Nervous System

  1994cites this paper
• Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

  1993cites this paper