Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  European Journal of Pharmacology

• Publication date

  2010-02-25

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.ejphar.2009.11.036PMID 19932884PMCID PMC3724416
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Monoamine transporter as a target molecule for psychostimulants.

  2009cited by this paper
• Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions

  2008cited by this paper
• Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats.

  2008cited by this paper
• BDNF is essential to promote persistence of long-term memory storage

  2008cited by this paper
• Effects of physical and psychological stress on 5-HT2A receptor-mediated wet-dog shake responses in streptozotocin-induced diabetic rats.

  2007cited by this paper
• Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice.

  2007cited by this paper
• [Strategy to develop a new drug for treatment-resistant depression--role of electroconvulsive stimuli and BDNF].

  2007cited by this paper
• Repeated electroconvulsive stimuli have long-lasting effects on hippocampal BDNF and decrease immobility time in the rat forced swim test.

  2007cited by this paper
• Norepinephrine Transporter Blockade can Normalize the Prepulse Inhibition Deficits Found in Dopamine Transporter Knockout Mice

  2006cited by this paper
• Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

  2006cited by this paper
• Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment.

  2006cited by this paper
• Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats.

  2006cited by this paper
• Endogenous BDNF is required for long-term memory formation in the rat parietal cortex.

  2005cited by this paper
• Regional Differences in Extracellular Dopamine and Serotonin Assessed by In Vivo Microdialysis in Mice Lacking Dopamine and/or Serotonin Transporters

  2004cited by this paper
• Effect of humanin analogues on experimentally induced impairment of spatial memory in rats

  2004cited by this paper
• Increased response switching, perseveration and perseverative switching following d-amphetamine in the rat

  2004cited by this paper
• Food‐Reinforced Operant Behavior in Dopamine Transporter Knockout Mice: Enhanced Resistance to Extinction

  2004cited by this paper
• Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior.

  2004cited by this paper
• The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory.

  2004cited by this paper
• An analysis of independence and interactions of brain substrates that subserve multiple attributes, memory systems, and underlying processes.

  2004cited by this paper
• Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.

  2003influential reference
• BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice

  2003influential reference
• From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.

  2002cited by this paper
• The human genome: mutations.

  2002cited by this paper
• The neurobiological basis of spontaneous alternation.

  2002cited by this paper
• The Role of D1-Dependent Dopaminergic Mechanisms of the Frontal Cortex in Delayed Responding in Rats

  2001cited by this paper
• Dopamine regulates brain-derived neurotrophic factor (BDNF) expression in cultured embryonic mouse striatal cells

  2001influential reference
• Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers

  2001cited by this paper
• Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

  2001cited by this paper
• Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease.

  2001cited by this paper
• Neurotrophins as synaptic modulators

  2001cited by this paper
• [Gly14]‐Humanin improved the learning and memory impairment induced by scopolamine in vivo

  2001cited by this paper
• Neurobiology of schizophrenia

  2000cited by this paper
• Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats

  2000cited by this paper
• Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

  1999cited by this paper
• Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

  1999cited by this paper
• Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone.

  1998cited by this paper
• A role for BDNF in the late-phase of hippocampal long-term potentiation.

  1998cited by this paper
• Dopamine axons in primate prefrontal cortex: specificity of distribution, synaptic targets, and development.

  1998cited by this paper
• Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.

  1998cited by this paper
• Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS.

  1998cited by this paper
• Neurobiology of schizophrenia.

  1997cited by this paper
• Regional and cellular fractionation of working memory.

  1996cited by this paper
• D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons

  1995cited by this paper
• Perseveration without hyperlocomotion in a spontaneous alternation task in rats sensitized to the dopamine agonist quinpirole.

  1995cited by this paper
• The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task.

  1994cited by this paper
• Repeated stress causes reversible impairments of spatial memory performance.

  1994cited by this paper
• Behavioural changes after ablation of subdivisions of the rat prefrontal cortex.

  1993cited by this paper
• The anatomy of dopamine in monkey and human prefrontal cortex.

  1992cited by this paper
• Distribution of dopaminergic receptors in the primate cerebral cortex: quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390.

  1991cited by this paper
• D1 dopamine receptors in prefrontal cortex: involvement in working memory

  1991cited by this paper

• Sildenafil promotes dual memory effects in young rats: involvement of dopamine reuptake

  2025cites this paper
• The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction.

  2025cites this paper
• Increasing spatial working memory in mice with Akkermansia muciniphila

  2025cites this paper
• Rodent research of attention-deficit/hyperactivity disorder: insights into widely used animal models

  2025cites this paper
• Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles

  2025cites this paper
• An updated review on animal models to study attention-deficit hyperactivity disorder

  2024cites this paper
• Effects of Quercetin against fluoride-induced neurotoxicity in the medial prefrontal cortex of rats: A stereological, histochemical and behavioral study.

  2024cites this paper
• Design and Synthesis of Phyto-Saxagliptin Conjugates: Targeting DPP IV, AChE, and β-Amyloid in Cognitive Impairment

  2024cites this paper
• Scopolamine animal model of memory impairment.

  2024cites this paper
• Longitudinal markers of cognitive procedural learning in fronto-striatal circuits and putative effects of a BDNF plasticity-related variant

  2024cites this paper
• Lipid metabolism in dopaminergic neurons influences light entrainment

  2023influential citation
• Behavioral profile of adult zebrafish acutely exposed to a selective dopamine uptake inhibitor, GBR 12909

  2023cites this paper
• Age-dependent effects of dopamine on working memory and synaptic plasticity in hippocampal CA3-CA1 synapses in mice.

  2023cites this paper
• Ameliorative and Neuroprotective Effect of Core-Shell Type Se@Au Conjugated Hesperidin Nanoparticles in Diabetes-Induced Cognitive Impairment

  2023cites this paper
• Mechanistic study of gold nanoparticles of Vildagliptin and Vitamin E in diabetic cognitive impairment

  2023cites this paper
• Dopamine Transporter Deficient Rodents: Perspectives and Limitations for Neuroscience

  2023cites this paper
• Mechanisms Underlying Cognitive Impairment Induced by Prenatal Alcohol Exposure

  2022cites this paper
• miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway

  2022cites this paper
• Animal Models of ADHD?

  2022cites this paper
• Dopamine-related polymorphisms and Affective Working Memory in aging.

  2022cites this paper
• Rodent models of attention-deficit hyperactivity disorder: An updated framework for model validation and therapeutic drug discovery.

  2022cites this paper
• Animal Model of Neonatal Immune Challenge by Lipopolysaccharide: A Study of Sex Influence in Behavioral and Immune/Neurotrophic Alterations in Juvenile Mice

  2022cites this paper
• A role for flavonoids in the prevention and/or treatment of cognitive dysfunction, learning, and memory deficits: a review of preclinical and clinical studies

  2022influential citation
• Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches.

  2021cites this paper
• Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept.

  2021cites this paper
• Spatial working memory is disparately interrelated with social status through different developmental stages in rats.

  2021cites this paper
• Timing behavior in genetic murine models of neurological and psychiatric diseases

  2021cites this paper
• Chronic administration of methylphenidate did not affect memory and GDNF levels but increase astrogliosis in adult male rat's hippocampus.

  2020cites this paper
• Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression

  2020cites this paper
• Deficit in working memory and abnormal behavioral tactics in dopamine transporter knockout rats during training in the 8-arm maze.

  2020cites this paper
• Impairment to Cognitive Functions in Wistar Rats in a Model of the Preclinical Stage of Parkinson’s Disease

  2020cites this paper
• Lister hooded rats as a novel animal model of attention-deficit/hyperactivity disorder.

  2020cites this paper
• Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.

  2020cites this paper
• Neonatal 6-OHDA Lesion Model in Mouse Induces Cognitive Dysfunctions of Attention-Deficit/Hyperactivity Disorder (ADHD) During Young Age

  2020cites this paper
• Nestorone exerts long-term neuroprotective effects against transient focal cerebral ischemia in adult male rats.

  2019cites this paper
• Dopamine and Working Memory: Genetic Variation, Stress and Implications for Mental Health.

  2019cites this paper
• Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice.

  2019cites this paper
• Gene knockout animal models of depression, anxiety and obsessive compulsive disorders.

  2019cites this paper
• The dopamine transporter role in psychiatric phenotypes

  2018cites this paper
• Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia

  2018cites this paper
• Dopamine D3 receptor blockade rescues hyper‐dopamine activity‐induced deficit in novel object recognition memory

  2018cites this paper
• Neonatal 6-OHDA lesion model in mouse induces Attention-Deficit/ Hyperactivity Disorder (ADHD)-like behaviour

  2018cites this paper
• No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice

  2018cites this paper
• Mesolimbic Dopamine, Its Receptors and Social Learning

  2018cites this paper
• Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.

  2017cites this paper
• Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania.

  2017cites this paper
• Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders

  2017influential citation
• Modeling Depression in Animals: Behavior as the Basis for the Methodology, Assessment Criteria, and Classification

  2017cites this paper
• Cortical Plasticity in Depression

  2017cites this paper
• Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development

  2017cites this paper
• Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene

  2017cites this paper
• Exploring the Validity of Proposed Transgenic Animal Models of Attention-Deficit Hyperactivity Disorder (ADHD)

  2017cites this paper
• Dopaminergic control of anxiety in young and aged zebrafish

  2017cites this paper
• Research Domain Criteria versus DSM V: How does this debate affect attempts to model corticostriatal dysfunction in animals?

  2017cites this paper
• Working memory genetics in schizophrenia and related disorders: An RDoC perspective

  2016cites this paper
• Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice.

  2016cites this paper
• SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

  2016cites this paper
• Development of New Analytical Method Evaluating Working Memory on Y Maze

  2016cites this paper
• Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine

  2016cites this paper
• The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children

  2016cites this paper
• A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes.

  2016cites this paper
• Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory

  2016cites this paper
• Development of New Analytical Method Evaluating Working Memory on Y Maze

  2016cites this paper
• BDNF concentrations and daily fluctuations differ among ADHD children and respond differently to methylphenidate with no relationship with depressive symptomatology

  2016cites this paper
• Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence

  2016influential citation
• Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice.

  2015cites this paper
• The Power of Music on Alzheimer Disease and the Need toUnderstand the Underlying Molecular Mechanisms

  2015cites this paper
• [Animal Models of Depression: Behavior as the Basis for Methodology, Assessment Criteria and Classifications].

  2015cites this paper
• The Role of the Dopamine D5 Receptor and D1-D2 Receptor Heterooligomer Signalling in Rodent Prefrontal Cortex and Cognition

  2015cites this paper
• Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits.

  2015cites this paper
• Does serotonin deficit mediate susceptibility to ADHD?

  2015cites this paper
• Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence.

  2015cites this paper
• Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor expression and induces cognitive dysfunction in adult rats

  2014cites this paper
• YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET.

  2014cites this paper
• Gastrodin Ameliorates Memory Deficits in 3,3′-Iminodipropionitrile-Induced Rats: Possible Involvement of Dopaminergic System

  2014cites this paper
• A Study on the Mechanism by Which MDMA Protects Against Dopaminergic Dysfunction After Minimal Traumatic Brain Injury (mTBI) in Mice

  2014cites this paper
• Serotonin/Dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout

  2014cites this paper
• Coping with Unpredictability: Dopaminergic and Neurotrophic Responses to Omission of Expected Reward in Atlantic Salmon (Salmo salar L.)

  2014cites this paper
• Association between the DAT1 gene and spatial working memory in attention deficit hyperactivity disorder.

  2014cites this paper
• Designing modulators of 5-hydroxytryptamine signaling to treat abuse disorders

  2014cites this paper
• Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice.

  2014cites this paper
• Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound.

  2014cites this paper
• 3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.

  2014cites this paper
• Effect of Atomoxetine on Behavior of Outbred Mice in the Enrichment Discrimination Test

  2013cites this paper
• Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine.

  2013cites this paper
• Studying chemical and electrical neuronal dynamics as a platform for understanding schizophrenia

  2013cites this paper
• COMT rs4680 Met is not always the ‘smart allele’: Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese

  2013cites this paper
• Effect of Val66Met polymorphism in BDNF on attentional bias in an extroverted Chinese Han population.

  2013cites this paper
• Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia

  2013cites this paper
• Rodent models of ADHD.

  2012cites this paper
• Development of Hyperactivity and Anxiety Responses in Dopamine Transporter-Deficient Mice

  2012cites this paper
• Chronic haloperidol-induced spatial memory deficits accompany the upregulation of D(1) and D(2) receptors in the caudate putamen of C57BL/6 mouse.

  2012cites this paper
• Antidepressant-like effect of Fuzi total alkaloid on ovariectomized mice.

  2012cites this paper
• Cognitive deficits in a mouse model of pre‐manifest Parkinson’s disease

  2012cites this paper
• Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice

  2012cites this paper
• The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice.

  2012cites this paper
• Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat

  2012cites this paper
• Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning

  2012cites this paper
• Val/Val genotype of brain-derived neurotrophic factor (BDNF) Val⁶⁶Met polymorphism is associated with a better response to OROS-MPH in Korean ADHD children.

  2011cites this paper
• Animal models of attention-deficit/hyperactivity disorder.

  2011cites this paper