Stem cell factor expression, mast cells and inflammation in asthma

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Fundamental & Clinical Pharmacology

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1472-8206.2005.00390.xPMID 16448392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of glucocorticoids on stem cell factor expression in human asthmatic bronchi

  2006cited by this paper
• Synergistic effect of SCF and TNF‐α on the up‐regulation of cell‐surface expression of ICAM‐1 on human leukemic mast cell line (HMC)‐1 cells

  2005cited by this paper
• Stem Cell Factor Has a Suppressive Activity to IgE-Mediated Chemotaxis of Mast Cells1

  2005cited by this paper
• Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

  2005cited by this paper
• Catalytic Activity of Human ADAM33*

  2004cited by this paper
• The expression of stem cell factor and c‐kit receptor in human asthmatic airways

  2004cited by this paper
• Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit*

  2003cited by this paper
• Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells.

  2003cited by this paper
• Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors

  2003cited by this paper
• Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.

  2003cited by this paper
• STI571 inhibits growth and adhesion of human mast cells in culture

  2003cited by this paper
• Catalytic Properties of ADAM19*

  2003cited by this paper
• Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins.

  2003cited by this paper
• IL-9 Enhances the Growth of Human Mast Cell Progenitors Under Stimulation with Stem Cell Factor1

  2003cited by this paper
• Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c‐kit proto‐oncogene

  2003cited by this paper
• Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells.

  2003cited by this paper
• Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

  2003cited by this paper
• Functional and Biochemical Consequences of Abrogating the Activation of Multiple Diverse Early Signaling Pathways in Kit

  2003cited by this paper
• Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation.

  2003cited by this paper
• NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells?

  2002cited by this paper
• JAK2, complemented by a second signal from c‐kit or flt‐3, triggers extensive self‐renewal of primary multipotential hemopoietic cells

  2002cited by this paper
• Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration.

  2002cited by this paper
• Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders.

  2002cited by this paper
• Phosphatidylinositol 3-Kinase and Src Family Kinases Are Required for Phosphorylation and Membrane Recruitment of Dok-1 in c-Kit Signaling*

  2002cited by this paper
• Enhanced Hematopoiesis by Hematopoietic Progenitor Cells Lacking Intracellular Adaptor Protein, Lnk

  2002cited by this paper
• Rac2, a Hematopoiesis-Specific Rho GTPase, Specifically Regulates Mast Cell Protease Gene Expression in Bone Marrow-Derived Mast Cells

  2002cited by this paper
• Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.

  2002cited by this paper
• C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors.

  2002cited by this paper
• JAK 2 Is Associated With the c-kit Proto-oncogene Product and Is Phosphorylated in Response to Stem Cell Factor

  2002cited by this paper
• Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells

  2002cited by this paper
• NF-κB and TNF-α: A Positive Autocrine Loop in Human Lung Mast Cells?

  2002cited by this paper
• Role of p 38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

  2002cited by this paper
• Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor.

  2002cited by this paper
• Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor.

  2002cited by this paper
• Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

  2002cited by this paper
• Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain

  2002cited by this paper
• Role for the Adaptor Protein Grb10 in the Activation of Akt

  2002cited by this paper
• Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.

  2002cited by this paper
• Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins.

  2002cited by this paper
• Signaling through Extracellular Signal-regulated Kinase Is Required for Spermatogonial Proliferative Response to Stem Cell Factor*

  2001cited by this paper
• An Increase in Circulating Mast Cell Colony-Forming Cells in Asthma1

  2001cited by this paper
• Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma.

  2001cited by this paper
• SCF-induced airway hyperreactivity is dependent on leukotriene production.

  2001cited by this paper
• The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface.

  2001cited by this paper
• Human Mast Cell Apoptosis Is Regulated Through Bcl-2 and Bcl-XL

  2001cited by this paper
• Soluble Kit receptor blocks stem cell factor bioactivity in vitro.

  2001cited by this paper
• The stem cell factor, its properties and potential role in the airways.

  2001cited by this paper
• Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cγ

  2001cited by this paper
• Stem cell factor and IgE-stimulated murine mast cells produce chemokines (CCL2, CCL17, CCL22) and express chemokine receptors

  2001cited by this paper
• Stem Cell Factor Presentation to c-Kit

  2001cited by this paper
• Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

  2001cited by this paper
• Stem cell factor-induced migration of mast cells requires p38 mitogen-activated protein kinase activity.

  2001cited by this paper
• Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways

  2000cited by this paper
• Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.

  2000cited by this paper
• Stem cell factor and IL-2 act synergistically in inducing intraepithelial lymphocyte proliferation and cytokine production: upregulation of the IL-2 receptor gamma-chain and signaling via JAK-3.

  2000cited by this paper
• Demonstration of mast cell chemotactic activity in bronchoalveolar lavage fluid collected from asthmatic patients before and during pollen season.

  2000cited by this paper
• MEKK2 gene disruption causes loss of cytokine production in response to IgE and c‐Kit ligand stimulation of ES cell‐derived mast cells

  2000cited by this paper
• Mast cell and myeloid marker expression during early in vitro mast cell differentiation from human peripheral blood mononuclear cells.

  2000cited by this paper
• Tumor necrosis factor α promotes the expression of stem cell factor in synovial fibroblasts and their capacity to induce mast cell chemotaxis

  2000cited by this paper
• Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells.

  2000cited by this paper
• Stem Cell Factor Plays a Major Role in the Recruitment of Eosinophils in Allergic Pleurisy in Mice Via the Production of Leukotriene B41

  2000cited by this paper
• Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia*

  2000cited by this paper
• Nerve growth factor prevents apoptosis of cord blood‐derived human cultured mast cells synergistically with stem cell factor

  2000cited by this paper
• Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways.

  2000cited by this paper
• Stem Cell Factor Plays a Major Role in the Recruitment of Eosinophils in Allergic Pleurisy in Mice Via the Production of Leukotriene B4

  2000cited by this paper
• Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit

  2000cited by this paper
• Novel Autocrine and Paracrine Loops of the Stem Cell Factor/Chymase Network

  1999cited by this paper
• Lyn is activated during late G1 of stem-cell-factor-induced cell cycle progression in haemopoietic cells.

  1999cited by this paper
• Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts

  1999cited by this paper
• Stem cell factor-induced airway hyperreactivity in allergic and normal mice.

  1999cited by this paper
• Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13).

  1999cited by this paper
• Primitive myeloid cells express high levels of phospholipase A(2) activity in the absence of leukotriene release: selective regulation by stem cell factor involving the MAP kinase pathway.

  1999cited by this paper
• Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

  1999cited by this paper
• Erythropoietin- and stem cell factor-induced DNA synthesis in normal human erythroid progenitor cells requires activation of protein kinase Calpha and is strongly inhibited by thrombin.

  1999cited by this paper
• Cord–Blood–Derived Human Cultured Mast Cells Produce Interleukin 13 in the Presence of Stem Cell Factor

  1999cited by this paper
• Stem cell factor is localized in, released from, and cleaved by human mast cells.

  1999cited by this paper
• Thrombopoietin augments stem cell factor-dependent growth of human mast cells from bone marrow multipotential hematopoietic progenitors.

  1999cited by this paper
• Matrix metalloproteinase-9 production, a newly identified function of mast cell progenitors, is downregulated by c-kit receptor activation.

  1999cited by this paper
• Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.

  1999cited by this paper
• Socs1 binds to multiple signalling proteins and suppresses Steel factor‐dependent proliferation

  1999cited by this paper
• Inhibition of Spontaneous Receptor Phosphorylation by Residues in a Putative α-Helix in the KIT Intracellular Juxtamembrane Region*

  1999cited by this paper
• STAT Protein Recruitment and Activation in c-Kit Deletion Mutants*

  1999cited by this paper
• Primitive myeloid cells express high levels of phospholipase A2 activity in the absence of leukotriene release : Selective regulation by stem cell factor involving the MAP kinase pathway

  1999cited by this paper
• Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.

  1999cited by this paper
• Signaling via Src family kinases is required for normal internalization of the receptor c-Kit.

  1999cited by this paper
• Inhibition of stem cell factor- and nerve growth factor-induced morphological change by wortmannin in mast cells

  1999cited by this paper
• Human bronchial smooth muscle cells in culture produce stem cell factor.

  1999cited by this paper
• Human Mast Cells Produce and Differentially Express Both Soluble and Membrane‐Bound Stem Cell Factor

  1999cited by this paper
• Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation.

  1998cited by this paper
• Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis.

  1998cited by this paper
• Novel role of transmembrane SCF for mast cell activation and eotaxin production in mast cell-fibroblast interactions.

  1998cited by this paper
• Up- and down-regulation by glucocorticoids of the constitutive expression of the mast cell growth factor stem cell factor by human lung fibroblasts in culture.

  1998cited by this paper
• Interleukin-4 promotes the development of tryptase and chymase double-positive human mast cells accompanied by cell maturation.

  1998cited by this paper
• Targeted disruption of SHIP leads to Steel factor‐induced degranulation of mast cells

  1998cited by this paper
• Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.

  1998cited by this paper
• Human mast cells express stem cell factor

  1998cited by this paper
• SHP-1 Binds and Negatively Modulates the c-Kit Receptor by Interaction with Tyrosine 569 in the c-Kit Juxtamembrane Domain

  1998cited by this paper
• Stem cell factor mRNA expression and production in human nasal epithelial cells: contribution to the accumulation of mast cells in the nasal epithelium of allergy.

  1998cited by this paper
• Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1.

  1998cited by this paper
• Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis.

  1998cited by this paper

• Inflammatory Markers in Gastric Fluids Differentiate Patients With Eosinophilic Gastritis: Search for a Disease Screener

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• Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical Region

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• Current utilization trend of immortalized mast cell lines in allergy research: a systematic review

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• Modulation of Stem Cell Factor by Forskolin Inhibits the Progression of Tubule Interstitial Fibrosis

  2024cites this paper
• Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells.

  2024cites this paper
• Unlocking the regenerative key: Targeting stem cell factors for bone renewal

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• Biomarkers in asthma, potential for therapeutic intervention

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• The nasal basal cell population shifts towards a diseased phenotype with impaired barrier formation capacity in allergic rhinitis.

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• Transmembrane stem factor nanodiscs enhanced revascularization in a hind limb ischemia model in diabetic, hyperlipidemic rabbits

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• Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits

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• Insights into the Characteristics and Functions of Mast Cells in the Gut

  2023cites this paper
• Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function

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• Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits

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• ELK4 exerts opposite roles in cytokine/chemokine production and degranulation in activated mast cells

  2023cites this paper
• Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis.

  2023cites this paper
• Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.

  2023cites this paper
• RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis.

  2022cites this paper
• Protein Kinase C α and β compensate for each other to promote stem cell factor‐mediated KIT phosphorylation, mast cell viability and proliferation

  2022cites this paper
• Human Lung Mast Cells: Therapeutic Implications in Asthma

  2022cites this paper
• Investigational approaches for unmet need in severe asthma

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• KIT as a master regulator of the mast cell lineage.

  2022cites this paper
• Cellular Energetics of Mast Cell Development and Activation

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• The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

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• Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction

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  2019cites this paper
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  2018cites this paper
• Human mast cells and basophils—How are they similar how are they different?

  2018cites this paper
• Genetic background and antenatal risk factors of bronchopulmonary dysplasia

  2018cites this paper
• KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

  2017cites this paper
• Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma.

  2017cites this paper
• Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome

  2017cites this paper
• Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma

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• Secretoglobin Superfamily Protein SCGB3A2 Alleviates House Dust Mite-Induced Allergic Airway Inflammation in Mice

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• Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in rats.

  2015cites this paper
• The IL-33/ST2 axis: Role in health and disease.

  2015cites this paper
• Cytokine & Growth Factor Reviews

  2015cites this paper
• Etude fonctionnelle des formes oncogéniques de KIT : nouvelles stratégies d'inactivation de la signalisation oncogénique KIT

  2014cites this paper
• Interleukin-33 promotes the proliferation of mouse mast cells through ST2/MyD88 and p38 MAPK-dependent and Kit-independent pathways.

  2014cites this paper
• [Role and mechanism of tranilast preventing the progression of tubulointerstilial fibrosis in diabetic kidney diseases].

  2013cites this paper
• Molecular mechanisms of glucocorticoid action in mast cells.

  2013cites this paper
• Intermediary quantitative traits—an alternative in the identification of disease genes in asthma?

  2013cites this paper
• SHP2/PTPN11 PROTEIN-TYROSINE PHOSPHATASE PROMOTES MAST CELL HOMEOSTASIS AND SYSTEMIC MASTOCYTOSIS

  2013cites this paper
• Stem cell factor estimula células da musculatura lisa da traqueia a produzir TGF-β, FGF-2 E CCL3/MIP-1α

  2012cites this paper
• Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart.

  2012cites this paper
• Expressão de fator de crescimento semelhante à insulina (IGF-1), alvo da rapamicina em mamíferos (M-TOR), fator de célula tronco (SCF) e receptor C-KIT (CD117) em mastocitomas cutânios caninos em lâminas de arranjo de matriz tecidual (TMA)

  2012cites this paper
• STEM CELL FACTOR ESTIMULA CÉLULAS DA MUSCULATURA LISA DA TRAQUEIA A PRODUZIR TGF-β, FGF-2 E CCL3/MIP-1α.

  2012cites this paper
• Role of PTP-alpha in integrated c-Kit and Fc-epsilon R1 mast cell activation

  2012cites this paper
• Rôle de la protéine GILZ (Glucocorticoid-Induced Leucin Zipper) et des Cellules Dendritiques dans la régulation des réponses immunes de type allergique

  2012cites this paper
• Regulation of mast cell responses in health and disease.

  2011cites this paper
• Differential role of pi-3kinase p85 ( alpha & beta ) regulatory subunits in mast cell development

  2011cites this paper
• The naïve airway hyperresponsiveness of the A/J mouse is Kit-mediated

  2011cites this paper
• Mast Cell Infiltration Is Involved in Renal Interstitial Fibrosis in a Rat Model of Protein-Overload Nephropathy

  2010cites this paper
• Mesenchymal stem cells require MARCKS protein for directed chemotaxis in vitro.

  2010cites this paper
• Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma

  2010cites this paper
• CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation.

  2009cites this paper
• Bone marrow stem cell-mediated airway epithelial regeneration.

  2009cites this paper
• Plasminogen activator inhibitor‐1 and asthma: role in the pathogenesis and molecular regulation

  2009cites this paper
• Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung

  2009cites this paper
• ADAM8: a new therapeutic target for asthma

  2009cites this paper
• MAST HÜCRELERİNİN ENFLAMASYONDAKİ ROLÜ: İNSAN VE DENEYSEL HAYVAN MODELLERİ ÜZERİNDE YAPILAN ÇALIŞMALARIN DEĞERLENDİRİLMESİ

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