Chimeric interferon-gamma receptors demonstrate that an accessory factor required for activity interacts with the extracellular domain.

We determined the species specificity and function of structural domains of the interferon-gamma receptor (IFN-gamma R) by construction of human/murine chimeric IFN-gamma R cDNA clones and their expression in various cells. We demonstrate that we can reconstitute a biologically active IFN-gamma R in eukaryotic cells with chimeric receptors as long as the extracellular domain and an accessory factor are from the same species. These results indicate that the extracellular domain of the receptor interacts directly or indirectly with the species-specific accessory factor.

• Publication year

  1992

• Venue

  Journal of Biological Chemistry

• Publication date

  1992-02-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/s0021-9258(19)50588-9PMID 1531478
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

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