Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Molecular and Cellular Biology

• Publication date

  1988-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.8.12.5126-5131.1988PMID 2854192PMCID PMC365614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1988cited by this paper
• Two classes of PDGF receptor recognize different isoforms of PDGF.

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• Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation.

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• Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.

  1987influential reference
• Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

  1987cited by this paper
• Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells.

  1987cited by this paper
• Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.

  1987cited by this paper
• Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

  1987cited by this paper
• Interrelationship between growth factor-induced pH changes and intracellular Ca2+.

  1987cited by this paper
• Identification of residues required for ligand binding to the beta-adrenergic receptor.

  1987cited by this paper
• The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

  1987cited by this paper
• Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.

  1987cited by this paper
• Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

  1987cited by this paper
• Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src

  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
• Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

  1986cited by this paper
• Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein

  1985cited by this paper
• A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity

  1985cited by this paper
• Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

  1984cited by this paper
• Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.

  1984cited by this paper
• Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.

  1983cited by this paper
• Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.

  1983cited by this paper
• Platelet-derived growth factor binds specifically to receptors on vascular smooth muscle cells and the binding becomes nondissociable.

  1982cited by this paper
• Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.

  1982cited by this paper
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  1982cited by this paper
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  1980cited by this paper
• Assay of transforming activity of tumor virus DNA.

  1980cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper

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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1996cites this paper
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  1996cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1992cites this paper
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  1992cites this paper
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  1991cites this paper
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  1991cites this paper
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  1991cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper