Optimal medical therapy with or without PCI for stable coronary disease.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  New England Journal of Medicine

• Publication date

  2007-04-12

• Fields of study

  Medicine

• Identifiers
  DOI 10.1056/NEJMOA070829PMID 17387127
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

  2009cited by this paper
• Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.

  2008cited by this paper
• A pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents.

  2007cited by this paper
• Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents.

  2007cited by this paper
• Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden.

  2007cited by this paper
• The evolving pattern of symptomatic coronary artery disease in the United States and Canada: baseline characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial.

  2007cited by this paper
• Drug-eluting coronary stents--promise and uncertainty.

  2007cited by this paper
• Stent thrombosis in randomized clinical trials of drug-eluting stents.

  2007cited by this paper
• Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents.

  2007cited by this paper
• ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention—summary article: A report of the American college of cardiology/American heart association task force on practice guidelines(ACC/AHA/SCAI writing committee to update the 2001 guidelines for percutaneous coronary intervention)

  2006cited by this paper
• Coronary intervention for persistent occlusion after myocardial infarction.

  2006cited by this paper
• Economics methods in the Clinical Outcomes Utilizing percutaneous coronary Revascularization and Aggressive Guideline-driven drug Evaluation (COURAGE) trial.

  2006cited by this paper
• ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention

  2006cited by this paper
• Comparison of outcomes of percutaneous coronary interventions in patients of three age groups (<60, 60 to 80, and >80 years) (from the New York State Angioplasty Registry).

  2006cited by this paper
• Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Veterans Affairs Cooperative Studies Program no. 424.

  2006cited by this paper
• ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to update the 2001 Guidelines for Percutaneous Coronary Intervention

  2006cited by this paper
• Early invasive versus selectively invasive management for acute coronary syndromes.

  2005cited by this paper
• Percutaneous Coronary Intervention Versus Conservative Therapy in Nonacute Coronary Artery Disease: A Meta-Analysis

  2005cited by this paper
• Routine vs selective invasive strategies in patients with acute coronary syndromes: a collaborative meta-analysis of randomized trials.

  2005cited by this paper
• Intensive lipid lowering with atorvastatin in patients with stable coronary disease.

  2005cited by this paper
• ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients Wi

  2004cited by this paper
• The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results.

  2004cited by this paper
• From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.

  2003cited by this paper
• ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina).

  2003cited by this paper
• Seven-year outcome in the RITA-2 trial: coronary angioplasty versus medical therapy.

  2003cited by this paper
• From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.

  2003cited by this paper
• Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).

  2003cited by this paper
• The EUROPA trial

  2003cited by this paper
• Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials.

  2003cited by this paper
• ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina).

  2003cited by this paper
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.

  2002cited by this paper
• Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Randomized Intervention Trial of unstable Angina.

  2002cited by this paper
• Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.

  2001cited by this paper
• Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.

  2001cited by this paper
• [Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban].

  2001cited by this paper
• Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.

  2000cited by this paper
• Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.

  1999cited by this paper
• Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study

  1999cited by this paper
• Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators.

  1999cited by this paper
• Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators.

  1999cited by this paper
• Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction Final Report of the Lyon Diet Heart Study

  1999cited by this paper
• Coronary angioplasty versus medical therapy for angina: the second Randomised Intervention Treatment of Angina (RITA-2) trial. RITA-2 trial participants.

  1997cited by this paper
• Coronary angioplasty versus medical therapy for angina: the second Randomised Intervention Treatment of Angina (RITA-2) trial

  1997cited by this paper
• Sample size calculation for complex clinical trials with survival endpoints.

  1995cited by this paper
• Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

  1994cited by this paper
• A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease. Veterans Affairs ACME Investigators.

  1992cited by this paper
• Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators.

  1992cited by this paper
• Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.

  1991cited by this paper
• An overview of randomized trials of rehabilitation with exercise after myocardial infarction.

  1989cited by this paper
• Angiographic progression of coronary artery disease and the development of myocardial infarction.

  1988cited by this paper
• Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?

  1988cited by this paper
• Overview of results of randomized clinical trials in heart disease. I. Treatments following myocardial infarction.

  1988cited by this paper
• A modified log rank test for highly stratified data

  1987cited by this paper
• A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results.

  1982cited by this paper
• Regression Models and Life-Tables

  year unknowncited by this paper

• Comparing anatomical imaging with functional imaging for coronary artery disease: the limitations of vessel stenosis and the benefits of non-invasive measurement of fractional flow reserve

  2026cites this paper
• Determinants of Left Ventricular Ejection Fraction Improvement After Successful Percutaneous Coronary Intervention for Chronic Total Occlusion: A Study Using Myocardial Perfusion Imaging.

  2026cites this paper
• Stress Perfusion CMR Imaging-Guided Management and Prognosis in Patients With Suspected Coronary Heart Disease.

  2026cites this paper
• Machine learning-selected inflammation biomarkers for stable coronary artery disease with intermediate coronary lesions: potential for long-term prognosis in a multicenter cohort study.

  2026cites this paper
• Epicardial Fat Thickness as a Marker of Coronary Artery Disease Severity and Ischemic Burden: A Prospective Echocardiographic Study

  2026cites this paper
• Role of Coronary Revascularization in Patients with Ischemic Heart Disease and Heart Failure with Reduced Ejection Fraction

  2026cites this paper
• Non-invasive identification of high-risk plaques in non-culprit lesions of acute coronary syndrome.

  2026cites this paper
• Exploring coronary microvascular dysfunction from functional impairment and structural damage

  2026cites this paper
• Coronary anatomy detects, ischemia predicts: Real-world insights from the Nancy ischemia registry

  2026cites this paper
• Effects of ginseng berry saponins on cardiorespiratory fitness in patients with SCAD: a randomized, double-blinded, placebo-controlled trial

  2026cites this paper
• Immediate vs Delayed Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: 5-Year Outcomes From the COACT Randomized Trial.

  2026cites this paper
• Physiology‐ versus angiography‐guided percutaneous coronary intervention for people with coronary artery disease

  2026cites this paper
• Association Between Age and PCI Effectiveness in Stable CAD: Secondary Analysis of ORBITA-2.

  2026cites this paper
• Coronary plaque burden as a determinant of cardiovascular outcomes in patients undergoing percutaneous coronary intervention versus coronary artery bypass grafting: The Western Denmark Heart Registry

  2026cites this paper
• Myocardial ischemia: no supply/demand mismatch but reduced blood flow per beat.

  2026cites this paper
• How Sex and Race/Ethnicity Influence Interventional Cardiology Outcomes: What Do We Know?

  2026cites this paper
• Prognostic Impact of Untreated Chronic Coronary Artery Obstruction After Surgery for Aortic Regurgitation

  2026cites this paper
• Invasive and medical management approaches to non-acute myocardial ischaemic syndromes.

  2026cites this paper
• Preoperative medicine: evaluating and optimizing patients before anesthesia and surgery

  2026cites this paper
• Efficacy of Yuxintong capsule on cardiorespiratory fitness in patients with stable coronary heart disease: a multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

  2026cites this paper
• Qishen Yiqi Dropping Pills ameliorate acute myocardial infarction by modulating PKM2/STAT3 pathway-mediated metabolic reprogramming in macrophages.

  2026cites this paper
• Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.

  2025cites this paper
• Surgical Risk and Long-Term Mortality With PCI and CABG in Ischemic Left Ventricular Systolic Dysfunction

  2025cites this paper
• Symptoms, coronary artery disease and percutaneous coronary intervention: connecting the dots

  2025cites this paper
• Revascularization in Stable Coronary Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

  2025cites this paper
• Long-term prognostic value of myocardial perfusion scintigraphy in patients with suspected coronary artery disease: systematic review and meta-analysis

  2025cites this paper
• Computed tomography angiography in chronic coronary syndrome: Association to catheterization laboratory activity and survival

  2025cites this paper
• Real-world effectiveness of early revascularization in stable coronary artery disease with moderate or severe ischemia

  2025cites this paper
• Coronary flow reserve increase after 4-year dapagliflozin treatment in patients with type 2 diabetes: the DAPAHEART follow-up study

  2025influential citation
• Comparison of computed tomography coronary angiography (CTCA) alone vs. CTCA with selective FFRCT in patients presenting with stable chest pain: a FORECAST trial substudy

  2025cites this paper
• Coronary Intervention: History and Current Status

  2025cites this paper
• Leveraging stress testing as a risk modifier: Optimization of medical therapy after SPECT MPI.

  2025cites this paper
• Vascular (dys)function in the failing heart

  2025influential citation
• Effect of Complete Revascularization in STEMI: Ischemia-Driven Rehospitalization and Cardiovascular Mortality

  2025cites this paper
• Myocardial Ischaemic Syndromes in Chronic Kidney Disease: Risky Pathways from Non-Acute to Acute Events.

  2025cites this paper
• Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease.

  2025cites this paper
• Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial

  2025cites this paper
• Permissibility & Necessity in the Ethical Justification of RCTs: The Four Quadrants Framework and the Case of Endovascular Thrombectomy Trials for Acute Ischemic Stroke.

  2025cites this paper
• Coronary chronic total occlusions: What's in a name and how do we treat it?

  2025cites this paper
• Practice patterns and percutaneous coronary intervention outcomes: a comparison between Sweden and the US

  2025cites this paper
• Incremental diagnostic value of coronary computed tomography angiography derived fractional flow reserve to detect ischemia

  2025cites this paper
• The role of cardiac imaging in the post-ISCHEMIA world

  2025cites this paper
• 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.

  2025cites this paper
• Clinical Factors Associated With Three-Year Cardiovascular Outcomes in Women Who Underwent Invasive Coronary Angiography: Data From the KoRean wOmen’S chest pain rEgistry (KoROSE)

  2025cites this paper
• A machine learning model using echocardiographic myocardial strain to detect myocardial ischemia

  2025cites this paper
• Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization

  2025cites this paper
• Cardiovascular Care in Women Veterans: An Updated Profile

  2025cites this paper
• Moderation of financial stress and cardiovascular disease risk in black catholics: A social-ecological pathway utilizing latent class and structural equation analyses

  2025cites this paper
• Revascularization versus optimal medical therapy in chronic coronary syndrome in women: A systematic review.

  2025cites this paper
• Impact of Left Ventricular Function on Outcomes in Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention.

  2025cites this paper
• Preoperative long-term use of renin-angiotensin-aldosterone system blockers increases the risk of acute kidney injury after coronary artery bypass grafting

  2025cites this paper
• Management and Outcomes of Patients Undergoing Cardiovascular Evaluation Across Health Care Systems: Comparison of Community Care and Integrated Veterans Affairs Health Care

  2025cites this paper
• Nanomedicine in cardiovascular and cerebrovascular diseases: targeted nanozyme therapies and their clinical potential and current challenges

  2025cites this paper
• Chronisches Koronarsyndrom – Update

  2025cites this paper
• Advanced Analyses of Coronary Computed Tomography Angiography to Predict Future Cardiac Events: A Meta-Analysis.

  2025cites this paper
• [Coronary Angioplasty among Women in Morocco].

  2025cites this paper
• A CENTURY of progress: using physiology-based imaging to improve patient outcomes in chronic coronary artery disease.

  2025cites this paper
• The Role of Myocardial Revascularization in Ischemic Heart Failure in the Era of Modern Optimal Medical Therapy

  2025cites this paper
• Clinical Impact of CT-Based FFR in Everyday Cardiology: Bridging Computation and Decision-Making

  2025cites this paper
• Two-year outcomes of quantitative flow ratio-based physiology-guided percutaneous coronary intervention in patients with low-risk acute coronary syndrome: a prespecified secondary analysis of FAVOR III China

  2025cites this paper
• Optimal medical therapy for initial management of stable angina: a call to action.

  2025cites this paper
• Periprocedural Assessment of Coronary Microcirculatory Function to Predict Clinical Outcomes After Elective Percutaneous Coronary Intervention

  2025cites this paper
• Comparative outcomes of invasive versus conservative strategy in stable coronary artery disease patients: a risk-stratification-based hypothesis-generative study

  2025cites this paper
• Invasive coronary angiography has limited diagnostic accuracy for detecting reduction of myocardial perfusion assessed by cardiac magnetic resonance.

  2025cites this paper
• Mode of revascularization for ischaemic cardiomyopathy: comparing apples with oranges?

  2025cites this paper
• Pullback pressure gradient: A paradigm shift in physiology-guided revascularization.

  2025cites this paper
• Physiological stenosis assessment for coronary artery surgery: quo vadis?

  2025cites this paper
• Optimal Medical Treatment Versus Percutaneous Coronary Intervention in Chronic Coronary Syndrome

  2025influential citation
• Management of Angina Pectoris.

  2025cites this paper
• Changes in coronary disease management decisions in real-world practice between 2015 and 2023: insights from the EVAREST/BSE-NSTEP observational study

  2025cites this paper
• Portuguese National Registry of Interventional Cardiology: Official report of percutaneous coronary angiography and intervention from 2014 to 2023.

  2025cites this paper
• The History of Angina and Its Remedies: COURAGE, ORBITA, and a Path Forward.

  2025cites this paper
• The temporal association between percutaneous coronary intervention and intradialytic hypotension in hemodialysis patients

  2025cites this paper
• Ischemia and Anatomy in the New 2024 European Guidelines for Chronic Coronary Syndromes: Update and Comparison of Recommendations

  2025influential citation
• Optimal timing for percutaneous coronary intervention in patients undergoing transcatheter aortic valve replacement: A network meta-analysis.

  2025cites this paper
• Chronic coronary syndrome in Africa: current management and service challenges, and opportunities for optimizing patient care.

  2025cites this paper
• Clinical Significance of Coronary Flow Reserve Improvement After Elective Percutaneous Coronary Intervention

  2025cites this paper
• Outcomes After Noncardiac Surgery Performed Within 2 Years of Percutaneous Coronary Intervention

  2025cites this paper
• From coronary artery disease to atherosclerotic coronary artery disease: what is in a name?

  2025cites this paper
• The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma.

  2025cites this paper
• CCTA-Guided Selective Invasive Coronary Catheterization: A Strategy to Reduce Contrast Volume and Improve Efficiency

  2025cites this paper
• Trimetazidine in Cardiovascular Disease and Beyond: A Comprehensive Review

  2025cites this paper
• Myocardial Revascularization in Patients with Diabetes and Heart Failure—A Narrative Review

  2025cites this paper
• CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials

  2025cites this paper
• Cost-effectiveness of stress echocardiography and exercise tolerance tests as screening in asymptomatic adults before starting physical activity

  2025cites this paper
• Does stress echocardiography change the selection of patients for invasive angiography and revascularization? Insights from the EVAREST/BSE-NSTEP Study.

  2025cites this paper
• Risk of Myocardial Infarction in Patients With Aortic Stenosis

  2025cites this paper
• 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.

  2025cites this paper
• Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction?

  2025cites this paper
• Semiquantitative metrics of coronary artery disease burden: Intra-individual comparison between ultrahigh-resolution photon-counting detector CT and energy-integrating detector CT.

  2025cites this paper
• Frailty Burden and Efficacy of Initial Invasive Strategy in Chronic Coronary Disease: The ISCHEMIA Trials

  2025cites this paper
• Global, regional, and national trends in tobacco-induced cardiovascular disease burden for 1990–2021 with projections to 2045: A comprehensive analysis based on the Global Burden of Disease Study 2021

  2025cites this paper
• Use of Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Intervention and Associated Outcomes in the ISCHEMIA Trial.

  2025cites this paper
• Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention.

  2025cites this paper
• Understanding preferences of patients with multivessel coronary artery disease towards revascularisation and optimal medical therapy: a protocol for a discrete choice experiment

  2025cites this paper
• Incidence, Predictors, and Outcomes of Complete Angina Relief in Symptomatic Patients in the ISCHEMIA Trial

  2025influential citation
• What Is New in Risk Assessment in Nuclear Cardiology?

  2025cites this paper
• Clinical outcomes of patients with acute myocardial infarction undergoing coronary revascularization via simplified treatment: a single-center retrospective study.

  2025cites this paper
• Management of Coronary Artery Disease in the Context of Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis of Percutaneous Coronary Intervention Timing and an Algorithmic Approach to Management

  2025cites this paper
• Insights from Autopsy-initiated Pathological Studies of the Pathogenesis and Clinical Manifestations of Atherosclerosis and Ischemic Heart Disease: Part II. Ischemic Heart Disease.

  2025cites this paper