Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Environmental and Molecular Mutagenesis

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/em.21700PMID 22619112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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• Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration

  1991cited by this paper
• International Commission for Protection Against Environmental Mutagens and Carcinogens.

  1979cited by this paper
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