Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Immunology

• Publication date

  1994-04-01

• Fields of study

  Medicine

• Identifiers
  PMID 7518791PMCID PMC1422373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Antigen analogues as antagonists of the T cell receptor.

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• Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events.

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• Outsize peptides bulge out of the groove.

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• Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling

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• Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

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• Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo

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• An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction.

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• Immunology. MHC class II dimer of dimers.

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• Parameters of tolerance induction by antigen targeted to B lymphocytes.

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• Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides.

  1993cited by this paper
• Effects of oral administration of type II collagen on rheumatoid arthritis.

  1993cited by this paper
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• Identifying strategies for immune intervention.

  1993cited by this paper
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  1993cited by this paper
• Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

  1993cited by this paper
• T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues.

  1993cited by this paper
• Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

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• Determinant spreading and the dynamics of the autoimmune T-cell repertoire.

  1993cited by this paper
• Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands.

  1993cited by this paper
• Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

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• Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages

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• Irreversible association of peptides with class II MHC molecules in living cells

  1992cited by this paper
• The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

  1992cited by this paper
• A critical role for conserved residues in the cleft of HLA-A2 in presentation of a nonapeptide to T cells.

  1992cited by this paper
• Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation

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• Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

  1992cited by this paper
• Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two- residue contact motif

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• CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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• Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

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• Targeting autoantigen to B cells prevents the induction of a cell- mediated autoimmune disease in rats

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• A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis

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  1992cited by this paper
• pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule.

  1992cited by this paper
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  1992cited by this paper
• The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

  1992cited by this paper
• Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations

  1992cited by this paper
• Emerging principles for the recognition of peptide antigens by MHC class I molecules.

  1992cited by this paper
• Identification of a motif for HLA-DR1 binding peptides using M13 display libraries

  1992cited by this paper
• Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity.

  1992cited by this paper
• Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor.

  1992cited by this paper
• T cell epitope selection: dominance may be determined by both affinity for major histocompatibility complex and stoichiometry of epitope

  1992cited by this paper
• How MHC class II molecules work: peptide-dependent completion of protein folding.

  1992cited by this paper
• Getting some "backbone": how MHC binds peptides.

  1992cited by this paper
• Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.

  1992cited by this paper
• Peptide-MHC interaction in autoimmunity.

  1992cited by this paper
• Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy.

  1992cited by this paper
• Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens

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  1991cited by this paper
• The dendritic cell system and its role in immunogenicity.

  1991cited by this paper
• Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand.

  1991cited by this paper
• Testing of autoimmune therapy begins.

  1991cited by this paper
• Self and foreign peptides interact with intact and disassembled MHC class II antigen HLA-DR via tryptophan pockets.

  1991cited by this paper
• Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

  1991cited by this paper
• A role for peptide in determining MHC class II structure

  1991cited by this paper
• Immunotherapy in autoimmune diseases.

  1991cited by this paper
• Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1.

  1991cited by this paper
• Characterization of the signaling function of MHC class II molecules during antigen presentation by B cells.

  1991cited by this paper
• Antigen-driven bystander suppression after oral administration of antigens

  1991cited by this paper
• Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

  1991cited by this paper
• Identification of self peptides bound to purified HLA-B27

  1991cited by this paper
• Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

  1991cited by this paper
• Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7

  1991cited by this paper
• A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

  1991cited by this paper
• Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.

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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Peptide competition for antigen presentation.

  1990cited by this paper
• Antigen Recognition and Peptide‐Mediated Immunotherapy in Autoimmune Disease

  1990cited by this paper
• Could specific oral tolerance be a therapy for autoimmune disease?

  1990cited by this paper
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  1990cited by this paper
• The T lymphocyte in experimental allergic encephalomyelitis.

  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• Activation-driven programmed cell death and T cell receptor zeta eta expression.

  1989cited by this paper
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  1989cited by this paper
• Autoimmune disease: immunotherapy by peptides?

  1989cited by this paper
• Antigen presentation abrogated in cells expressing truncated Ia molecules.

  1989cited by this paper
• Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

  1989cited by this paper
• Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells

  1989cited by this paper
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  1988cited by this paper
• A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

  1988cited by this paper
• Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.

  1988cited by this paper
• In vivo competition between self peptides and foreign antigens in T-cell activation

  1988cited by this paper
• T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.

  1988cited by this paper
• Mechanisms influencing the immunodominance of T cell determinants

  1988cited by this paper
• Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

  1987cited by this paper
• Interaction between CD4 and class II MHC molecules mediates cell adhesion

  1987cited by this paper

• Design of Peptide Immunotherapies for MHC Class-II-Associated Autoimmune Disorders

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  2000cites this paper
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  1999cites this paper
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• Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis (EAE) in DA rats

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  1997cites this paper
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• Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseases.

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• Lymphocyte activation in health and disease.

  1997cites this paper
• Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-beta mRNA.

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  1996cites this paper
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  1996cites this paper
• 3rd International Symposium on the Immunotherapy of the Rheumatic Diseases. 10-14 May 1995, Cyprus. Abstracts.

  1995cites this paper
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  1995cites this paper
• AUTOIMMUNE MECHANISMS OF DEPLETION OF CD4 CELLS IN HIV INFECTION

  1995cites this paper
• Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

  1995cites this paper
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