Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Clinical Investigation

• Publication date

  2016-05-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI83551PMID 27088801PMCID PMC4855934
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

  2016cited by this paper
• Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes

  2015cited by this paper
• Anaemia in kidney disease: harnessing hypoxia responses for therapy

  2015cited by this paper
• Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo.

  2015cited by this paper
• Cell-specific translational profiling in acute kidney injury.

  2014cited by this paper
• Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis

  2014cited by this paper
• Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.

  2014cited by this paper
• The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury

  2014cited by this paper
• Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.

  2013cited by this paper
• Plasticity of renal erythropoietin-producing cells governs fibrosis.

  2013cited by this paper
• The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

  2012cited by this paper
• Biology of the renal pericyte.

  2012cited by this paper
• Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

  2012cited by this paper
• Myeloid Cell-Derived Hypoxia-Inducible Factor Attenuates Inflammation in Unilateral Ureteral Obstruction-Induced Kidney Injury

  2012cited by this paper
• Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

  2012cited by this paper
• Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis.

  2012cited by this paper
• Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice

  2011cited by this paper
• Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.

  2011cited by this paper
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

  2011cited by this paper
• Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization.

  2010cited by this paper
• A mouse model for an erythropoietin-deficiency anemia

  2010cited by this paper
• Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

  2010cited by this paper
• Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

  2010cited by this paper
• Erythropoiesis-stimulating agents--time for a reevaluation.

  2010cited by this paper
• Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.

  2010cited by this paper
• Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

  2010cited by this paper
• Epithelial and Mesenchymal Cell Biology Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

  2010cited by this paper
• The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

  2009cited by this paper
• A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

  2009cited by this paper
• The effect of altitude on dosing and response to erythropoietin in ESRD.

  2008cited by this paper
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Repression via the GATA box is essential for tissue-specific erythropoietin gene expression.

  2008cited by this paper
• Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.

  2008cited by this paper
• Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

  2008cited by this paper
• Potential mechanisms of adverse outcomes in trials of anemia correction with erythropoietin in chronic kidney disease.

  2008cited by this paper
• Administration of poly-D-glutamic acid induces proliferation of erythropoietin-producing peritubular cells in rat kidney.

  2007cited by this paper
• A global double‐fluorescent Cre reporter mouse

  2007cited by this paper
• Acute postnatal ablation of Hif-2alpha results in anemia.

  2007cited by this paper
• Acute postnatal ablation of Hif-2α results in anemia

  2007cited by this paper
• The new FDA label for erythropoietin treatment: how does it affect hemoglobin target?

  2007cited by this paper
• NG2 cells generate both oligodendrocytes and gray matter astrocytes

  2007cited by this paper
• Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

  2007cited by this paper
• Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

  2006cited by this paper
• Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.

  2006cited by this paper
• Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*

  2004cited by this paper
• The HIF family member EPAS 1 / HIF-2 is required for normal hematopoiesis in mice

  2003cited by this paper
• Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non‐diabetic chronic renal failure

  2002cited by this paper
• Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions.

  1999cited by this paper
• Heterogeneities and profiles of oxygen pressure in brain and kidney as examples of the pO2 distribution in the living tissue.

  1997cited by this paper
• Effects of anemia on morphology of rat renal cortex.

  1993cited by this paper
• Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin.

  1993cited by this paper
• Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration.

  1989cited by this paper
• Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration

  1989cited by this paper
• Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization.

  1988cited by this paper
• Effect of Altitude on Erythropoiesis and Oxygen Affinity in Anaemic Patients on Maintenance Dialysis

  1973cited by this paper

• Current research on the HIF-2α-EPO–Hb axis in hypoxic environments: from molecular mechanisms to clinical

  2026cites this paper
• Molecular pathways of kidney development and their applications to clinical research.

  2025cites this paper
• Endothelial Prolyl Hydroxylase 3 Mitigates Maladaptive Inflammation to Promote Post-Ischemic Kidney Repair

  2025cites this paper
• Impact of hyperbaric oxygenation therapy (HBOT) on renal function in human

  2025cites this paper
• The kidney stroma in development and disease

  2025cites this paper
• Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts

  2025influential citation
• Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometry.

  2025cites this paper
• Hypoxia-inducible factor 2α: at the interface between oxygen sensing systems in physiology and pathology

  2025cites this paper
• Erythropoietin production in embryonic neural cells is controlled by hypoxia-inducible factors and histone deacetylases in an undifferentiated state

  2024cites this paper
• Single-cell lineage tracing approaches to track kidney cell development and maintenance.

  2024cites this paper
• Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia

  2024cites this paper
• Erythropoietin Production in Embryonic Neural Cells is Controlled by Hypoxia Signaling and Histone Deacetylases with an Undifferentiated Cellular State

  2024cites this paper
• PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions

  2024influential citation
• Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia

  2023cites this paper
• Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells.

  2023cites this paper
• Endotyping COPD: hypoxia-inducible factor-2 as a molecular “switch” between the vascular and airway phenotypes?

  2023cites this paper
• The transcriptional and regulatory identity of erythropoietin producing cells

  2023cites this paper
• Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

  2022cites this paper
• Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia

  2022cites this paper
• The fate of erythropoietin-producing cells: another piece of the puzzle.

  2022cites this paper
• Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations.

  2022cites this paper
• Fount, fate, features, and function of renal erythropoietin-producing cells

  2022cites this paper
• The effect of HIF on metabolism and immunity

  2022cites this paper
• Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche.

  2022cites this paper
• Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors.

  2022cites this paper
• EPO synthesis induced by HIF‐PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non‐injured nephron segments in murine kidney fibrosis

  2022cites this paper
• Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?

  2022cites this paper
• WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease

  2022cites this paper
• Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases

  2022cites this paper
• Effects of PHD and HSP90 on erythropoietin production in yak (Bos grunniens) renal interstitial fibroblast-like cells under hypoxia

  2022cites this paper
• Disturbance of Hypoxia Response and Its Implications in Kidney Diseases

  2022cites this paper
• Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells

  2022cites this paper
• Fate‐mapping of erythropoietin‐producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality

  2022cites this paper
• Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation

  2022cites this paper
• Foxc1 and Foxc2 are indispensable for maintenance of progenitors of nephron and stroma in the developing kidney.

  2022cites this paper
• Pharmacologic HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation

  2021cites this paper
• Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

  2021cites this paper
• Kidney pericyte hypoxia-inducible factor regulates erythropoiesis but not kidney fibrosis.

  2021cites this paper
• Molecular characterization of the human kidney interstitium in health and disease

  2021cites this paper
• Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

  2021cites this paper
• Smad4 controls proliferation of interstitial cells in the neonatal kidney.

  2021cites this paper
• HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla

  2021cites this paper
• Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2

  2021cites this paper
• Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin‐expressing cells of mouse kidneys

  2021cites this paper
• Pre-natal Development of the Kidneys and Urinary Tract

  2021cites this paper
• Hypoxia-Inducible Factor Stabilization as an Emerging Therapy for CKD-Related Anemia: Report From a Scientific Workshop Sponsored by the National Kidney Foundation.

  2021cites this paper
• Hypoxia signaling in renal pericytes-is it safe to activate?

  2021cites this paper
• Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney

  2021cites this paper
• CD226 deficiency promotes glutaminolysis and alleviates mitochondria damage in vascular endothelial cells under hemorrhagic shock

  2021cites this paper
• Pharmacological HIF‐PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation

  2021cites this paper
• Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity

  2020cites this paper
• The Many Facets of Erythropoietin Physiologic and Metabolic Response

  2020cites this paper
• Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1.

  2020cites this paper
• Erythropoietin production by the kidney and the liver in response to severe hypoxia evaluated by Western blotting with deglycosylation

  2020cites this paper
• Proliferation control of kidney interstitial cells

  2020cites this paper
• Parathyroid Glands in Chronic Kidney Disease

  2020cites this paper
• Molecular regulation and function of FoxO3 in chronic kidney disease.

  2020cites this paper
• Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo.

  2020cites this paper
• Effect of PTH on the Hematologic System

  2020cites this paper
• Janus-Faced: Molecular Mechanisms and Versatile Nature of Renal Fibrosis.

  2020cites this paper
• The journey from erythropoietin to 2019 Nobel Prize: Focus on hypoxia-inducible factors in the kidney.

  2020cites this paper
• The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion

  2020cites this paper
• Hypoxia pathway proteins regulate the synthesis and release of epinephrine in the mouse adrenal gland

  2020influential citation
• Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis

  2020cites this paper
• Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression

  2020influential citation
• HIF-prolyl hydroxylase inhibitors in renal anemia: current clinical experience

  2020cites this paper
• progress on the relationship between erythropoietin-producing cells and anemia and fibrosis in chronic kidney disease

  2020cites this paper
• The Role of Hypoxia in Metabolism and Nephron Development

  2019cites this paper
• Hypoxia-Inducible Factor A ACKD ctivators in Renal Anemia : Current Clinical Experience

  2019cites this paper
• Mechanisms of hypoxia signalling: new implications for nephrology

  2019cites this paper
• Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.

  2019cites this paper
• The profibrotic effects of MK‐8617 on tubulointerstitial fibrosis mediated by the KLF5 regulating pathway

  2019cites this paper
• Perivascular CD73+ cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment.

  2019cites this paper
• Stromal prorenin receptor is critical for normal kidney development.

  2019cites this paper
• FoxO3 activation in hypoxic tubules prevents chronic kidney disease.

  2019cites this paper
• Renal Development and Molecular Pathogenesis of Renal Dysplasia

  2019cites this paper
• Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype.

  2019cites this paper
• Erythropoiesis, EPO, macrophages, and bone.

  2019cites this paper
• The ER cargo receptor SURF4 facilitates efficient erythropoietin secretion

  2019cites this paper
• Mechanisms of Renal Fibrosis.

  2018cites this paper
• VEGF expands erythropoiesis via hypoxia-independent induction of erythropoietin in noncanonical perivascular stromal cells

  2018cites this paper
• Physiology and pathophysiology of renal erythropoietin-producing cells.

  2018cites this paper
• HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.

  2018cites this paper
• Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond

  2018cites this paper
• Source and microenvironmental regulation of erythropoietin in the kidney

  2018cites this paper
• Fludrocortisone stimulates erythropoietin production in the intercalated cells of the collecting ducts.

  2018cites this paper
• The multisystemic functions of FOXD1 in development and disease

  2018cites this paper
• Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases.

  2018cites this paper
• Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response

  2018cites this paper
• Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease

  2017cites this paper
• Natural compound bavachalcone promotes the differentiation of endothelial progenitor cells and neovascularization through the RORα-erythropoietin-AMPK axis

  2017cites this paper
• The loss of Krüppel-like factor 15 in Foxd1+ stromal cells exacerbates kidney fibrosis.

  2017cites this paper
• Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.

  2017cites this paper
• Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.

  2017cites this paper
• Origin and Function of the Renal Stroma in Health and Disease.

  2017cites this paper
• HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

  2017cites this paper
• Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion.

  2017cites this paper
• Oxygen sensors as therapeutic targets in kidney disease.

  2017cites this paper
• Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

  2017cites this paper
• (Re)Building a Kidney.

  2017cites this paper