TLR4 enhances TGF-β signaling and hepatic fibrosis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Medicine

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/nm1663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene expression profiles during hepatic stellate cell activation in culture and in vivo.

  2007cited by this paper
• A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C

  2007cited by this paper
• LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice.

  2006cited by this paper
• Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

  2006cited by this paper
• Proinflammatory Cytokine Production in Liver Regeneration Is Myd88-Dependent, but Independent of Cd14, Tlr2, and Tlr41

  2006cited by this paper
• Toll-like receptor signaling in the liver.

  2006cited by this paper
• Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury1

  2006cited by this paper
• IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.

  2005cited by this paper
• Anandamide induces necrosis in primary hepatic stellate cells

  2005cited by this paper
• Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

  2005cited by this paper
• Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282)

  2005cited by this paper
• Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo

  2005cited by this paper
• Regulation of lung injury and repair by Toll-like receptors and hyaluronan

  2005cited by this paper
• IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

  2005cited by this paper
• High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

  2005cited by this paper
• Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells.

  2005cited by this paper
• Contribution of Toll‐like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

  2005cited by this paper
• Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells1

  2005cited by this paper
• The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

  2005cited by this paper
• Cytokines and the pathogenesis of non-alcoholic steatohepatitis

  2005cited by this paper
• Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

  2005cited by this paper
• LPS-mediated NFκB activation varies between activated human hepatic stellate cells from different donors

  2004cited by this paper
• Effect of Nma on growth inhibition by TGF-betaa in human gastric carcinoma cell lines.

  2004cited by this paper
• NF-κB functions as a tumour promoter in inflammation-associated cancer

  2004cited by this paper
• Liver fibrosis

  2004cited by this paper
• Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.

  2004cited by this paper
• Toll-like receptor signalling

  2004cited by this paper
• Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

  2004cited by this paper
• Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway1

  2004cited by this paper
• Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor Cells*

  2004cited by this paper
• Transcriptional regulation of the TGF-β pseudoreceptor BAMBI by TGF-β signaling

  2004cited by this paper
• Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.

  2003cited by this paper
• Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells

  2003cited by this paper
• DNase I–hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells

  2003cited by this paper
• Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

  2003cited by this paper
• NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.

  2003cited by this paper
• Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

  2002cited by this paper
• Toll‐like receptor 4 is involved in the mechanism of early alcohol‐induced liver injury in mice

  2001cited by this paper
• Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β1

  2001cited by this paper
• Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine.

  2001cited by this paper
• Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury*

  2000cited by this paper
• Zebrafish nma is involved in TGFβ family signaling

  2000cited by this paper
• Silencing of TGF-β signalling by the pseudoreceptor BAMBI

  1999cited by this paper
• NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

  1998cited by this paper
• Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

  1998cited by this paper
• The role of gut‐derived bacterial toxins and free radicals in alcohol‐induced liver injury

  1998cited by this paper
• Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model.

  1997cited by this paper
• Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.

  1994cited by this paper
• Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

  1989cited by this paper
• Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice

  1988cited by this paper

• Juzentaihoto modulates gut microbiota and potentiates the anti-tumor effect of anti-PD-1 antibody in an immunogenic mouse melanoma model.

  2026cites this paper
• The macrophage opera: from metabolic prolog to oncogenic crescendo in metabolic dysfunction-associated steatotic liver disease.

  2026cites this paper
• Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells

  2026cites this paper
• Ligature-induced periodontitis exacerbates high-carbohydrate/high-fat diet-induced fatty liver in mice under non-diabetic conditions.

  2026cites this paper
• Design and Optimization of Potent, Selective, and Peripherally Acting JNK3 Inhibitors for Chronic Kidney Disease

  2026cites this paper
• The "Immune Rebellion" from the Intestines to the Liver: A Vicious Cycle That Causes the Liver to Collapse.

  2026cites this paper
• Exploring the prediction model and core genes for coronary artery disease in non-obese steatotic liver disease patients.

  2026cites this paper
• Fasciola hepatica excretory and secretory products reprogram the Kupffer cell transcriptome to modulate hepatic damage progression.

  2026cites this paper
• Hepatocyte–hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications

  2026cites this paper
• Targeting the gut microbiota: the application and prospects of probiotics, fecal microbiota transplantation, and natural products in MASLD

  2026cites this paper
• Bile salt hydrolase activity as a rational target for MASLD therapy

  2026cites this paper
• Gut Microbiota-Mediated Molecular Events in Hepatocellular Carcinoma: From Pathogenesis to Treatment

  2026cites this paper
• Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases.

  2026cites this paper
• Gut microbial signatures of advanced hepatocellular carcinoma and their potential diagnostic value

  2026cites this paper
• Restoration of ethanol-induced Bifidobacterium pseudocatenulatum depletion ameliorates alcohol-associated liver disease

  2026cites this paper
• Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands

  2025cites this paper
• Frontier progress and translational challenges of pluripotent differentiation of stem cells

  2025cites this paper
• Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD

  2025cites this paper
• Hyperammonemia induces programmed liver cell death

  2025cites this paper
• The outcomes and mechanisms of chronic hepatitis B complicated by metabolic dysfunction-associated steatotic liver disease.

  2025cites this paper
• α-Amanitin aggravates hepatic injury by activating oxidative stress and mitophagy via peroxiredoxin 6 inhibition

  2025cites this paper
• Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations

  2025cites this paper
• Bicuculline from Forsythia suspensa attenuates liver fibrosis via TLR4/MD2 inhibition and suppression of MyD88/NF-κB signaling

  2025cites this paper
• Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics.

  2025cites this paper
• Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression

  2025cites this paper
• Mechanism of Curcumin in the Treatment of Intrauterine Adhesions Based on Network Pharmacology, Molecular docking, and Experimental Validation

  2025cites this paper
• Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease

  2025cites this paper
• Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights

  2025cites this paper
• Long-chain acylcarnitine deficiency promotes hepatocarcinogenesis

  2025cites this paper
• Recent advances in small molecule design strategies against hepatic fibrosis.

  2025cites this paper
• Liver as a key organ for systemic antimicrobial defense

  2025cites this paper
• Regulatory role of gut microbiota in chronic hepatitis B: A perspective from the gut-liver axis

  2025cites this paper
• Lars2-signaling mediates platinum resistance by accumulating cancer stem cell population and suppressing anti-tumor immunity.

  2025cites this paper
• Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction-Associated Steatohepatitis.

  2025cites this paper
• Procyanidin B2 alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the NF-κB/JAK2/STAT1 signaling pathway.

  2025cites this paper
• Potential role of immune-related LncRNAs in prognosis of hepatocellular carcinoma: an integrative study

  2025cites this paper
• Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing

  2025cites this paper
• Paederia scandens-derived exosome-like nanoparticles as a delivery system for andrographolide to treat ulcerative colitis.

  2025cites this paper
• Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts

  2025cites this paper
• Biomechanical Networks of the Pre-Metastatic Niche: Decoding Biophysical Determinants of Tumor Metastatic Organotropism.

  2025cites this paper
• Association of biliary microflora dysbiosis with cholangiocarcinoma: a single-center study

  2025cites this paper
• Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR–NLRP3 axis

  2025cites this paper
• Pharmacological treatment for metabolic dysfunction-associated steatotic liver disease and related disorders: Current and emerging therapeutic options.

  2025cites this paper
• Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies?

  2025cites this paper
• Immune Checkpoints and the Immunology of Liver Fibrosis

  2025cites this paper
• Immune Dysfunction and Infection Risk in Advanced Liver Disease.

  2025cites this paper
• Quantifying the intra- and inter-species community interactions in microbiomes by dynamic covariance mapping

  2025cites this paper
• Rifaximin Attenuates Liver Fibrosis and Hepatocarcinogenesis in a Rat MASH Model by Suppressing the Gut–Liver Axis and Epiregulin–IL-8-Associated Angiogenesis

  2025cites this paper
• Long-term intake of a high-carbohydrate diet induced steatosis, hepatitis, and fibrosis in the liver of juvenile Chinese soft-shelled turtle (Pelodiscus sinensis)

  2025cites this paper
• NLRP3 Inflammasome Activation in Liver Disorders: From Molecular Pathways to Therapeutic Strategies

  2025cites this paper
• Extracellular vesicle-dependent crosstalk between hepatic stellate cells and Kupffer cells promotes their mutual activation.

  2025cites this paper
• Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells

  2025cites this paper
• Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization

  2025cites this paper
• Procalcitonin as a Predictive Marker of Incident Liver Disease

  2025cites this paper
• Selenoprotein K-dependent MyD88 palmitoylation promotes hepatic metaflammation in high-fat diet fed mice.

  2025cites this paper
• A novel RELA K119 deacetylation mediated by SIRT7 is a pivotal activator to exacerbate liver inflammation and fibrosis in teleosts

  2025cites this paper
• Aging and Aging-Related Senescence in Liver

  2025cites this paper
• Transforming Growth Factor-β Signaling in Alcohol-Associated Liver Disease

  2025cites this paper
• New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis

  2025cites this paper
• Dysbiosis and extraintestinal cancers

  2025cites this paper
• Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice

  2025cites this paper
• The interactive role of microRNA and other non-coding RNA in hepatitis B (HBV) associated fibrogenesis

  2025cites this paper
• LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

  2025cites this paper
• Sesamin improved growth and overall health in young animals by enhancing gut-liver axis function.

  2025cites this paper
• Commentary on “Toll-like receptor 5-mediated signaling enhances liver regeneration in mice” and the Role of Different TLR Families in Liver Regeneration

  2025cites this paper
• New insights into therapeutic strategies for targeting hepatic macrophages to alleviate liver fibrosis.

  2025cites this paper
• Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression

  2025cites this paper
• Biliary atresia: Rotavirus amplification of lipopolysaccharide/toll-like receptor 4 by mediating MMP7 upregulation through NF-κB

  2025cites this paper
• Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA

  2025cites this paper
• The spatial and temporal activation of macrophages during fibrosis

  2025cites this paper
• The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure

  2025cites this paper
• Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma

  2025cites this paper
• Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice

  2025cites this paper
• From cooperation to collapse: systemic failure in liver disease through a sociological lens

  2025cites this paper
• Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro

  2025cites this paper
• The Sugar-coated truth of alcohol-associated liver disease: Galectins as multi-faceted regulators of Alcohol-induced liver injury.

  2025cites this paper
• Exploring the Mechanisms of Lipopolysaccharide-Induced Liver Damage in a Rat Model

  2025cites this paper
• Microbiota composition and intestinal barrier function modulated by tamsulosin and Lactococcus lactis in a cirrhosis rat model

  2025cites this paper
• Alpha-pinene ameliorates liver fibrosis by suppressing oxidative stress, inflammation, and the TGF-β/Smad3 signaling pathway

  2025cites this paper
• Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5-HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis.

  2025cites this paper
• Redox-sensitive high mobility group box 1 (HMGB1) is a multifunctional regulator of cellular senescence, inflammation, and immunosuppression: impact on the aging process.

  2025cites this paper
• Microbial Modulation of the Gut–Liver Axis in Autoimmune Liver Diseases

  2025cites this paper
• The gut microbiome and gastrointestinal cancers: mechanisms, biomarkers and therapeutic opportunities

  2025cites this paper
• SARS‐CoV‐2: A Liver Brief

  2025cites this paper
• The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets

  2025cites this paper
• LGALS3 promotes liver fibrosis by enhancing the expression and phosphorylation of ERK1/2

  2025cites this paper
• Neutrophil extracellular traps (NETs) and fibrotic diseases.

  2024cites this paper
• Inflammation and Exosomes in Fabry Disease Pathogenesis

  2024cites this paper
• Exploring Advanced Therapies for Primary Biliary Cholangitis: Insights from the Gut Microbiota–Bile Acid–Immunity Network

  2024cites this paper
• Sja-let-7 suppresses the development of liver fibrosis via Schistosoma japonicum extracellular vesicles

  2024cites this paper
• Research progress on the mechanism of traditional Chinese medicine in the treatment of autoimmune hepatitis

  2024cites this paper
• Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms

  2024cites this paper
• Targeting inflammation in perivascular cells and neuroimmune interactions for treating kidney disease

  2024cites this paper
• Research reviews and prospects of gut microbiota in liver cirrhosis: a bibliometric analysis (2001–2023)

  2024cites this paper
• mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection

  2024cites this paper
• Research Progress of the Effects of Long-Term Use of Proton Pump Inhibitors on Non-Alcoholic Fatty Liver Disease

  2024cites this paper
• Review: Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases.

  2024cites this paper
• Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis.

  2024cites this paper
• Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease.

  2024cites this paper
• The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts

  2024cites this paper