Toward optimization of AgoshRNA moleculesthat use a non-canonical RNAi pathway: Variations in the top and bottom base pairs

No abstract is available for this paper.

• Publication year

  2015

• Venue

  RNA Biology

• Publication date

  2015-03-06

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/15476286.2015.1022024PMID 25747107PMCID PMC4615845
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-1 in the RNA world: Transcription regulation, miRNAs and antiviral RNAs

  2015influential reference
• Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.

  2014cited by this paper
• Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity

  2014cited by this paper
• Designing Ago2-specific siRNA/shRNA to Avoid Competition with Endogenous miRNAs

  2014cited by this paper
• Towards improved shRNA and miRNA reagents as inhibitors of HIV-1 replication.

  2014cited by this paper
• Dicer-independent processing of short hairpin RNAs

  2013influential reference
• Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery

  2013cited by this paper
• Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs.

  2013cited by this paper
• Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

  2012cited by this paper
• microRNAs associated with the different human Argonaute proteins

  2012cited by this paper
• The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.

  2012cited by this paper
• Biogenesis of mammalian microRNAs by a non-canonical processing pathway

  2012cited by this paper
• Functional parameters of Dicer-independent microRNA biogenesis.

  2012cited by this paper
• Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants.

  2011cited by this paper
• The effects of stem length and core placement on shRNA activity

  2011cited by this paper
• Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity.

  2010cited by this paper
• A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

  2010cited by this paper
• Optimization of shRNA inhibitors by variation of the terminal loop sequence.

  2010cited by this paper
• Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

  2010cited by this paper
• Combinatorial RNAi Against HIV-1 Using Extended Short Hairpin RNAs

  2009cited by this paper
• Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

  2008cited by this paper
• Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

  2008cited by this paper
• Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

  2007cited by this paper
• Defining the optimal parameters for hairpin-based knockdown constructs.

  2007cited by this paper
• Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology

  2006cited by this paper
• Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.

  2006cited by this paper
• Silencing of HIV-1 with RNA interference: a multiple shRNA approach.

  2006cited by this paper
• Synthetic shRNAs as potent RNAi triggers

  2005cited by this paper
• Novel methods for expressing RNA interference in human cells.

  2005cited by this paper
• MicroRNA biogenesis: coordinated cropping and dicing

  2005cited by this paper
• HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

  2005cited by this paper
• Mfold web server for nucleic acid folding and hybridization prediction

  2003cited by this paper
• Induction of an interferon response by RNAi vectors in mammalian cells

  2003cited by this paper
• A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

  2002cited by this paper
• Expanding small RNA interference

  2002cited by this paper
• Development of a Self-Inactivating Lentivirus Vector

  1998cited by this paper
• Supplemental Materials and Methods: Linker Ligation

  year unknowncited by this paper

• Design of antiviral AGO2-dependent short hairpin RNAs

  2024cites this paper
• One locus, several functional RNAs—emerging roles of the mechanisms responsible for the sequence variability of microRNAs

  2023cites this paper
• VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy

  2022cites this paper
• Gene knockdown in malaria parasites via non-canonical RNAi

  2019cites this paper
• Boosting AgoshRNA activity by optimized 5’-terminal nucleotide selection

  2019cites this paper
• Influence of a 3′ Terminal Ribozyme on AgoshRNA Biogenesis and Activity

  2019cites this paper
• Dicer-independent processing of small RNA duplexes: mechanistic insights and applications

  2017cites this paper
• Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage

  2017cites this paper
• Silencing of HIV-1 by AgoshRNA molecules

  2017cites this paper
• Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection

  2017cites this paper
• Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity

  2017cites this paper
• Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2.

  2016cites this paper
• Off Target, but Sequence-Specific, shRNA-Associated Trans-Activation of Promoter Reporters in Transient Transfection Assays

  2016cites this paper
• The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site

  2016cites this paper
• REGULATORY MODIFICATIONS OF MICRORNA AND SHORT HAIRPIN RNA PRECURSORS

  2015influential citation
• Bone Marrow Gene Therapy for HIV/AIDS

  2015cites this paper