IL-23 Receptor Regulates Unconventional IL-17–Producing T Cells That Control Bacterial Infections

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Immunology

• Publication date

  2010-01-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.0902796PMID 20083652PMCID PMC2829977
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  2000cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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