From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units.

Bacteria in nature reside in organized communities, termed biofilms, which are composed of multiple individual cells adhering to each other. Similarly, tumors are a multicellular mass with distinct cellular phenotypes. Both tumors and biofilms are considered to be an active interphase between unicellular and multicellular life states. Because both of these units depend on glutamine for growth and survival, we review here glutamine flux within them as a readout for intra- and inter-commensal metabolism. We suggest that the difference between glutamine fluxes in these cellular communities lies mainly in their global multicellular metabolic organization. Both the differences and similarities described here should be taken into account when considering glutamine-targeting therapeutic approaches.

• Publication year

  2017

• Venue

  Trends in endocrinology and metabolism

• Publication date

  2017-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tem.2017.05.007PMID 28641927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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