An analogy between the evolution of drug resistance in bacterial communities and malignant tissues

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature Reviews. Cancer

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/nrc3039PMID 21508974PMCID PMC3488437
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallmarks of cancer

  2012cited by this paper
• Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications.

  2011cited by this paper
• Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance.

  2010cited by this paper
• Large-scale in silico modeling of metabolic interactions between cell types in the human brain

  2010cited by this paper
• A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.

  2010cited by this paper
• Purified human BRCA2 stimulates RAD51-mediated recombination

  2010cited by this paper
• Sources and sinks: a stochastic model of evolution in heterogeneous environments.

  2010cited by this paper
• Mutational robustness can facilitate adaptation

  2010cited by this paper
• Bacterial charity work leads to population-wide resistance

  2010cited by this paper
• An introduction to micro-ecology patches.

  2010cited by this paper
• A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces.

  2010cited by this paper
• Cell density and mobility protect swarming bacteria against antibiotics

  2010cited by this paper
• Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

  2010cited by this paper
• Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer.

  2010cited by this paper
• Role of Mutation in Pseudomonas aeruginosa Biofilm Development

  2009cited by this paper
• Tumor self-seeding by circulating cancer cells.

  2009cited by this paper
• The developmental model of microbial biofilms: ten years of a paradigm up for review.

  2009cited by this paper
• Reconstruction of biochemical networks in microorganisms

  2009cited by this paper
• Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

  2009cited by this paper
• DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions

  2009cited by this paper
• Microenvironmental regulation of metastasis

  2009cited by this paper
• Oncogene addiction.

  2008cited by this paper
• Physiological heterogeneity in biofilms

  2008cited by this paper
• 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells

  2008cited by this paper
• VEGF-targeted therapy: mechanisms of anti-tumour activity

  2008cited by this paper
• Diagnosing and exploiting cancer's addiction to blocks in apoptosis

  2008cited by this paper
• Computation of mutual fitness by competing bacteria

  2008cited by this paper
• An overview of cancer multidrug resistance: a still unsolved problem

  2008cited by this paper
• Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

  2008cited by this paper
• An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models.

  2008cited by this paper
• Endogenous oxidative stress produces diversity and adaptability in biofilm communities

  2008cited by this paper
• Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis

  2008cited by this paper
• Increased mutability of Pseudomonas aeruginosa in biofilms.

  2008influential reference
• On the foundations of cancer modelling: Selected topics, speculations, and perspectives

  2008cited by this paper
• Why is cancer drug discovery so difficult?

  2007cited by this paper
• Extracellular matrix regulation of drug resistance in small-cell lung cancer

  2007cited by this paper
• Drug resistance and the solid tumor microenvironment.

  2007cited by this paper
• Spatial Patterns of DNA Replication, Protein Synthesis, and Oxygen Concentration within Bacterial Biofilms Reveal Diverse Physiological States

  2007cited by this paper
• Social evolution theory for microorganisms

  2006cited by this paper
• Human cancers express a mutator phenotype

  2006cited by this paper
• Evolvability

  2006cited by this paper
• Fibroblasts in cancer

  2006cited by this paper
• Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.

  2006cited by this paper
• Tumor stroma and regulation of cancer development.

  2006cited by this paper
• Evolvability.

  2006cited by this paper
• Genetic clonal diversity predicts progression to esophageal adenocarcinoma

  2006cited by this paper
• Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance

  2005cited by this paper
• Molecular mechanisms of drug resistance

  2005cited by this paper
• Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat

  2005cited by this paper
• A microfluidic chemostat for experiments with bacterial and yeast cells

  2005cited by this paper
• Biofilms: the matrix revisited.

  2005cited by this paper
• Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies.

  2005cited by this paper
• Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance in Pseudomonas aeruginosa Strains Causing Chronic Lung Infections

  2005cited by this paper
• A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation.

  2005cited by this paper
• Bacterial Persistence as a Phenotypic Switch

  2004cited by this paper
• Evolvability is a selectable trait.

  2004cited by this paper
• Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

  2004cited by this paper
• Why do cancers have high aerobic glycolysis?

  2004cited by this paper
• The Combination of Genetic Instability and Clonal Expansion Predicts Progression to Esophageal Adenocarcinoma

  2004cited by this paper
• Stress-Induced Mutagenesis in Bacteria

  2003cited by this paper
• Diffusion in Biofilms

  2003cited by this paper
• A pulsating auroral X-ray hot spot on Jupiter

  2002cited by this paper
• Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

  2002cited by this paper
• Extracellular matrix regulation of drug resistance in small-cell lung cancer.

  2002cited by this paper
• Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms

  2002cited by this paper
• Modelling the molecular circuitry of cancer

  2002cited by this paper
• Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse Gut

  2001cited by this paper
• Antibiotic resistance of bacteria in biofilms.

  2001cited by this paper
• The microenvironment of the tumour–host interface

  2001cited by this paper
• Quorum sensing in bacteria.

  2001cited by this paper
• Growth and Detachment of Cell Clusters from Mature Mixed-Species Biofilms

  2001cited by this paper
• High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.

  2000cited by this paper
• Identification of additional genes belonging to the LexA regulon in Escherichia coli

  2000cited by this paper
• Emergence of a subpopulation in a computational model of tumor growth.

  2000cited by this paper
• Bacterial biofilms: a common cause of persistent infections.

  1999cited by this paper
• Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

  1999cited by this paper
• Phenotypic change caused by transcriptional bypass of uracil in nondividing cells.

  1999cited by this paper
• Brca1 controls homology-directed DNA repair.

  1999cited by this paper
• Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa.

  1999cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• Involvement of Brca2 in DNA repair.

  1998cited by this paper
• DNA gyrase, topoisomerase IV, and the 4-quinolones

  1997cited by this paper
• Role of mutator alleles in adaptive evolution

  1997cited by this paper
• RecA protein: structure, function, and role in recombinational DNA repair.

  1997cited by this paper
• p53, the Cellular Gatekeeper Review for Growth and Division

  1997cited by this paper
• Evolution of high mutation rates in experimental populations of E. coli

  1997cited by this paper
• All rights reserved

  1997cited by this paper
• Database of p53 gene somatic mutations in human tumors and cell lines.

  1994cited by this paper
• The role of the sigma factor sigma S (KatF) in bacterial global regulation.

  1994cited by this paper
• Microbial competition: Escherichia coli mutants that take over stationary phase cultures.

  1993cited by this paper
• Inducible DNA repair systems.

  1985cited by this paper
• Evolution and the Theory of Games

  1982cited by this paper
• Gene amplification and drug resistance in cultured murine cells.

  1978cited by this paper
• A Still Unsolved Problem

  1969cited by this paper
• Evolution and the theory of games.

  1961cited by this paper

• Sustainable Water Treatment Through Fractional-Order Chemostat Modeling with Sliding Memory and Periodic Boundary Conditions: A Mathematical Framework for Clean Water and Sanitation

  2025cites this paper
• Evolutionary Transcriptomics of Cancer Development

  2025cites this paper
• Early tolerance and late persistence as alternative drug responses in cancer

  2025cites this paper
• Impact of the intracellular mechanical microenvironment of breast cancer and normal mammary epithelial cells on magnetic hyperthermia of Fe3O4 nanoparticles.

  2025cites this paper
• Evaluating the therapeutic potential of amygdalin: Cytotoxic and antimicrobial properties.

  2024cites this paper
• Evaluation of the Proliferative Effects of Hexagonal Boron Nitride Nanoparticles on Leukemia Cells and Leukemia Stem Cells

  2024cites this paper
• UV-B-Induced DNA Repair Mechanisms and Their Effects on Mutagenesis and Culturability in Escherichia coli

  2024cites this paper
• Bacterial motility can govern the dynamics of antibiotic resistance evolution

  2023cites this paper
• Convergent TP53 loss and evolvability in cancer

  2023cites this paper
• Acetylation of xenogeneic silencer H-NS regulates biofilm development through the nitrogen homeostasis regulator in Shewanella

  2023cites this paper
• α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal

  2023cites this paper
• Enabling direct microcalorimetric measurement of metabolic activity and exothermic reactions onto microfluidic platforms via heat flux sensor integration

  2023cites this paper
• Common themes in antimicrobial and anticancer drug resistance

  2022influential citation
• Evo-devo perspectives on cancer.

  2022cites this paper
• A RETROSPECTIVE OBSERVATIONAL STUDY ON CASES OF SARCOMA TREATED WITH THE DI BELLA METHOD: RATIONALE AND EFFECTIVENESS

  2022cites this paper
• A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness

  2022cites this paper
• Drug resistance: from bacteria to cancer

  2021cites this paper
• Effects of different salinity conditions on the transcriptome and antibiotic resistance of two Vibrio parahaemolyticus strains isolated from Penaeus vannamei cultured in seawater and freshwater ponds.

  2021cites this paper
• Single-Cell Analysis for Whole-Organism Datasets.

  2021cites this paper
• Novel and Future Treatment Strategies for Biofilm-Associated Infections

  2021cites this paper
• Collective metastasis: coordinating the multicellular voyage

  2021cites this paper
• Studies on drug-assisted silver nanoparticles to reduce granulocytopenia and improve drug delivery for cancer therapy

  2021cites this paper
• Adaptive Evolution: How Bacteria and Cancer Cells Survive Stressful Conditions and Drug Treatment.

  2021cites this paper
• Microfluidic Evolution-On-A-Chip Reveals New Mutations that Cause Antibiotic Resistance.

  2021cites this paper
• Germline Evolution in Cancer as Explained by the Germ and Soma Theory of Dual Cell Systems

  2021cites this paper
• Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer.

  2021cites this paper
• Dynamic motility selection drives population segregation in a bacterial swarm

  2020cites this paper
• Characterizing the Motility of Chemotherapeutics-Treated Acute Lymphoblastic Leukemia Cells by Time-Lapse Imaging

  2020cites this paper
• The Cancer Principle-III: Evolution by Cancer

  2020cites this paper
• Dissection of the mutation accumulation process during bacterial range expansions

  2020cites this paper
• Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

  2020cites this paper
• Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

  2020cites this paper
• Cancer-associated fibroblast compositions change with breast-cancer progression linking S100A4 and PDPN ratios with clinical outcome

  2020cites this paper
• An in vitro tumor swamp model of heterogeneous cellular and chemotherapeutic landscapes.

  2020cites this paper
• The evolution of multicellularity and cancer: views and paradigms.

  2020cites this paper
• A mouse model-based screening platform for the identification of immune activating compounds such as natural products for novel cancer immunotherapies.

  2019cites this paper
• Cellular heterogeneity results from indirect effects under metabolic tradeoffs

  2019cites this paper
• The reproductive life cycle of cancer: Hypotheses of cell of origin, TP53 drivers and stem cell conversions in the light of the atavistic cancer cell theory.

  2019cites this paper
• The association between hypoxia, chronic ischemia and alters prostate structure and progress of chronic prostatic disease

  2019cites this paper
• Collective motion conceals fitness differences in crowded cellular populations

  2018cites this paper
• Simulating biological processes: stochastic physics from whole cells to colonies

  2018cites this paper
• Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells

  2018cites this paper
• A bacterial antibiotic resistance accelerator and applications.

  2018cites this paper
• Predicting the evolution of Escherichia coli by a data-driven approach

  2018cites this paper
• MetaSMC: a coalescent-based shotgun sequence simulator for evolving microbial populations

  2018cites this paper
• Nothing in cancer makes sense except…

  2018cites this paper
• Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies

  2018cites this paper
• "Clicking" Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions.

  2018cites this paper
• Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity

  2018cites this paper
• Visualisation of transcription-coupled repair in live Escherichia coli

  2018cites this paper
• The madness of crowds phenomenon in the collective decision-making by the cells, the cell’s metacognition and cancer

  2018cites this paper
• Molecular and Cell Biological Considerations in the Initiation and Development of Sporadic Non-Hereditary Solid Cancers

  2018cites this paper
• The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology.

  2018cites this paper
• Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology.

  2017cites this paper
• Inactivation of tumor suppressor genes and cancer therapy: An evolutionary game theory approach.

  2017cites this paper
• Chapter 15 – Understanding Ancient Legacies to Expose and Exploit Cancer’s Evolutionary Vulnerabilities

  2017cites this paper
• Dormancy: An Evolutionary Key Phenomenon in Cancer Development

  2017cites this paper
• Single-molecule live-cell imaging of bacterial DNA repair and damage tolerance.

  2017cites this paper
• Emerging and evolving concepts in gene essentiality

  2017cites this paper
• HIV-1-infected T-cells dynamics and prognosis: An evolutionary game model

  2017cites this paper
• Using Game Theory for Real-Time Behavioral Dynamics in Microscopic Populations with Noisy Signaling

  2017influential citation
• Convection shapes the trade-off between antibiotic efficacy and the selection for resistance in spatial gradients

  2017cites this paper
• Phylostratigraphic analysis of tumor and developmental transcriptomes reveals relationship between oncogenesis, phylogenesis and ontogenesis

  2017cites this paper
• Key issues review: evolution on rugged adaptive landscapes

  2017cites this paper
• Commentary: How Evolution of Quorum Sensing Must Fit into the Understanding of The Origin, Prevention and Treatment of cancer

  2017cites this paper
• Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

  2017cites this paper
• Adaptive dynamics of unstable cancer populations: The canonical equation

  2017cites this paper
• From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units.

  2017cites this paper
• Cancer as robust intrinsic state shaped by evolution: a key issues review

  2017cites this paper
• Commentary : How Evolution of Quorum Sensing Must Fit into the Understanding of The Origin , Prevention and Treatment of cancer

  2017cites this paper
• Une approche multi-échelle des processus écologiques et évolutifs impliqués dans le cancer

  2017influential citation
• Precision Oncology: Between Vaguely Right and Precisely Wrong.

  2017cites this paper
• University of Groningen Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection

  2017cites this paper
• Allele surfing promotes microbial adaptation from standing variation.

  2016cites this paper
• Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?

  2016cites this paper
• Accumulation of Deleterious Mutations During Bacterial Range Expansions

  2016cites this paper
• Host manipulation by cancer cells: Expectations, facts, and therapeutic implications

  2016cites this paper
• Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance.

  2016cites this paper
• Allele Surfing Promotes Microbial Adaptation from Standing Variation

  2016cites this paper
• Evolution of Drug Resistance in Bacteria.

  2016cites this paper
• Molecular mechanisms and clinical implications of bacterial persistence.

  2016cites this paper
• Prospects & Overviews Host manipulation by cancer cells : Expectations , facts , and therapeutic implications

  2016cites this paper
• Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems.

  2016cites this paper
• Cooperation among cancer cells as public goods games on Voronoi networks.

  2016cites this paper
• ROLE OF HNRNP H IN A REVERSIBLE FINE-TUNING MECHANISM OFSPLICING RESPONSE UPON TRANSCRIPTIONAL PAUSING

  2016cites this paper
• Darwinian Strategies to Avoid the Evolution of Drug Resistance During Cancer Treatment

  2016cites this paper
• Evolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis

  2016cites this paper
• Serratia Secondary Metabolite Prodigiosin Inhibits Pseudomonas aeruginosa Biofilm Development by Producing Reactive Oxygen Species that Damage Biological Molecules

  2016cites this paper
• Antibiotic resistance: a physicist’s view

  2016cites this paper
• The unforeseen challenge: from genotype-to-phenotype in cell populations

  2015cites this paper
• Tumorigenesis: it takes a village

  2015cites this paper
• Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment

  2015cites this paper
• Evolutionary perspective of cancer: myth, metaphors, and reality

  2015cites this paper
• Anticancer Activities of Selected Species of North American Lichen Extracts

  2015cites this paper
• The Immunostimulating Role of Lichen Polysaccharides: A Review

  2015cites this paper
• Exploring the Antibacterial, Antioxidant, and Anticancer Properties of Lichen Metabolites

  2015cites this paper
• Computational aspects of presence of drug resistance mechanisms

  2015cites this paper
• The Effect of Horizontal Gene Transfer on the Dynamics of Antibiotic Drug Resistance in a Unicellular Population with a Dynamic Fitness Landscape, Repression and De-repression

  2015cites this paper
• NDM-1, novel TEM-205, novel TEM-213 and other extended-spectrum β-lactamases co-expressed in isolates from cystic fibrosis patients from South Africa

  2015cites this paper
• Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer

  2015cites this paper