2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Neurochemical Research

• Publication date

  2018-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11064-017-2453-zPMID 29497903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA‐128 promotes apoptosis in lung cancer by directly targeting NIMA‐related kinase 2

  2017cited by this paper
• Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: Changes in LC3, P62, Beclin-1 and Bcl-2 levels.

  2017cited by this paper
• MicroRNAs in epilepsy: pathophysiology and clinical utility.

  2016cited by this paper
• Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks

  2016cited by this paper
• Dynamic Expression of MicroRNAs (183, 135a, 125b, 128, 30c and 27a) in the Rat Pilocarpine Model and Temporal Lobe Epilepsy Patients.

  2015cited by this paper
• Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure.

  2015cited by this paper
• Neuronal mechanisms of epileptogenesis

  2014cited by this paper
• Neuronal mechanisms of epileptogenesis

  2014cited by this paper
• Epigenetic mechanisms in epilepsy.

  2014cited by this paper
• Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

  2014cited by this paper
• MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

  2013cited by this paper
• Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

  2012cited by this paper
• Cell-type-based analysis of microRNA profiles in the mouse brain.

  2012cited by this paper
• Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.

  2012cited by this paper
• MicroRNA-34a upregulation during seizure-induced neuronal death

  2012cited by this paper
• Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death.

  2012cited by this paper
• Effects of the group II mGlu receptor agonist 2R,4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury

  2011cited by this paper
• miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132.

  2011cited by this paper
• Comprehensive survey of human brain microRNA by deep sequencing

  2010cited by this paper
• A PCR-based platform for microRNA expression profiling studies.

  2009cited by this paper
• Does Pilocarpine-Induced Epilepsy in Adult Rats Require Status epilepticus?

  2009cited by this paper
• Early Deficits in Spatial Memory and Theta Rhythm in Experimental Temporal Lobe Epilepsy

  2009cited by this paper
• Temporal Lobe Sclerosis Associated With Hippocampal Sclerosis in Temporal Lobe Epilepsy: Neuropathological Features

  2009cited by this paper
• How common are the “common” neurologic disorders?

  2007cited by this paper
• 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation

  2007cited by this paper
• Adult epilepsy.

  2006cited by this paper
• Deficient memory acquisition in temporal lobe epilepsy is predicted by hippocampal granule cell loss

  2006cited by this paper
• Real-time quantification of microRNAs by stem–loop RT–PCR

  2005cited by this paper
• Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.

  2005cited by this paper
• 2R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test.

  2004cited by this paper
• Glutamate metabotropic receptors as targets for drug therapy in epilepsy.

  2003cited by this paper
• The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice.

  2001cited by this paper
• Identification of Novel Genes Coding for Small Expressed RNAs

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Lithium-pilocarpine-induced status epilepticus in immature rats result in long-term deficits in spatial learning and hippocampal cell loss.

  2001cited by this paper
• Early identification of refractory epilepsy.

  2000cited by this paper
• Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders.

  2000cited by this paper
• Metabotropic G-protein-coupled glutamate receptors as therapeutic targets.

  1999cited by this paper
• Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels.

  1999cited by this paper
• Glutamate receptors: brain function and signal transduction.

  1998cited by this paper
• Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats.

  1998cited by this paper
• Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist.

  1997cited by this paper
• Type 2 Metabotropic Glutamate (mGlu) Receptors Tonically Inhibit Transmitter Release in Rat Caudate Nucleus: In Vivo Studies with (2S,1′S,2′S,3′R)‐2‐(2′‐carboxy‐3′‐phenylcyclopropyl)glycine, a New Potent and Selective Antagonist

  1997cited by this paper
• Pharmacology and functions of metabotropic glutamate receptors.

  1997cited by this paper
• The metabotropic glutamate receptors: structure and functions.

  1995cited by this paper
• Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist.

  1995cited by this paper
• Glutamate, GABA and epilepsy.

  1995cited by this paper
• The role of glutamate in epilepsy and other CNS disorders

  1994cited by this paper
• Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity.

  1994cited by this paper
• Molecular diversity of glutamate receptors and implications for brain function.

  1992cited by this paper
• Excitatory amino acid receptors in epilepsy.

  1990cited by this paper
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper

• Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration

  2025cites this paper
• Exosomes in epilepsy: bridging neuroinflammation, diagnosis, and therapeutic delivery

  2025cites this paper
• Cognitive comorbidities in the rat pilocarpine model of epilepsy

  2024cites this paper
• miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes

  2022cites this paper
• Enduring effects of muscarinic receptor activation on adult hippocampal neurogenesis, microRNA expression and behaviour

  2019cites this paper
• MicroRNAs change the games in central nervous system pharmacology.

  2019cites this paper