Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Cancer Research

• Publication date

  1994-09-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 8069858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.

  1994cited by this paper
• Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes.

  1994cited by this paper
• Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens.

  1993cited by this paper
• Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.

  1993cited by this paper
• Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones.

  1993cited by this paper
• Glutathione and glutathione S-transferases in Barrett's epithelium.

  1993cited by this paper
• Immunohistochemical localization of alpha and pi class glutathione transferases in normal human tissues.

  1993cited by this paper
• Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.

  1993cited by this paper
• The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).

  1992cited by this paper
• Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.

  1992cited by this paper
• Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.

  1992cited by this paper
• Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat.

  1992cited by this paper
• Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.

  1992cited by this paper
• Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases.

  1992cited by this paper
• Gender related differences in the expression and characteristics of glutathione S-transferases of human colon.

  1992cited by this paper
• Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa.

  1992cited by this paper
• Metabolic activation and genotoxicity of heterocyclic arylamines.

  1992cited by this paper
• Acetyltransferases and susceptibility to chemicals.

  1992cited by this paper
• Identification of N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA.

  1992cited by this paper
• Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

  1992cited by this paper
• Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells.

  1992cited by this paper
• Glutathione transferases and cancer.

  1992cited by this paper
• Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats.

  1992cited by this paper
• Formation of a glutathione conjugate and a semistable transportable glucuronide conjugate of N2-oxidized species of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat liver.

  1991cited by this paper
• Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline in male Fischer-344 rats.

  1991cited by this paper
• Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.

  1991cited by this paper
• Carcinogenicities of heterocyclic amines in cooked food.

  1991cited by this paper
• Theta, a new class of glutathione transferases purified from rat and man.

  1991cited by this paper
• A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

  1991cited by this paper
• Quantification of human hepatic glutathione S-transferases.

  1990cited by this paper
• Carcinogenic aromatic amine metabolism and DNA adduct detection in humans.

  1990cited by this paper
• Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by liver microsomes and isolated rabbit cytochrome P450 isozymes.

  1990cited by this paper
• Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA.

  1990cited by this paper
• DNA Adducts Formed by 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline in Rat Liver: Dose‐Response on Chronic Administration

  1990cited by this paper
• The role of glutathione and glutathione transferases in chemical carcinogenesis.

  1990cited by this paper
• Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

  1990cited by this paper
• Enhancement by cysteinyl thiols of acetyltransferase-mediated, but not of sulfotransferase-mediated, binding of a pyrolysate-derived N-hydroxyarylamine, 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, to DNA.

  1990cited by this paper
• Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues.

  1990cited by this paper
• Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

  1989cited by this paper
• DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

  1989cited by this paper
• Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

  1989cited by this paper
• Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats.

  1989cited by this paper
• Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats.

  1989cited by this paper
• Metabolism of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in isolated rat liver cells.

  1989cited by this paper
• 4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat.

  1989cited by this paper
• Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450.

  1988cited by this paper
• Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat.

  1988cited by this paper
• Heterocyclic amine-DNA adducts analyzed by 32P-postlabeling method.

  1988cited by this paper
• Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ.

  1988cited by this paper
• Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

  1988cited by this paper
• Glutathione transferases--structure and catalytic activity.

  1988cited by this paper
• Acetylation phenotype in colorectal carcinoma.

  1987cited by this paper
• Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline (MeIQ) by subcellular fractions and cells isolated from small intestine, kidney and liver of the rat

  1987cited by this paper
• Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

  1987cited by this paper
• Mechanism of Protection against Aflatoxin Tumorigenicity in Rats Fed 5-(2-Pyrazinyl)-4-methyl-l,2-dithiol-3-thione (Oltipraz) and Related l,2-Dithiol-3-thiones and l

  1987cited by this paper
• Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods.

  1987cited by this paper
• Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit.

  1986cited by this paper
• Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract.

  1984cited by this paper
• Effect of glutathione and uridine-5'-diphosphoglucuronic acid on the mutagenicity of tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by rat-liver and -intestine S9 fraction.

  1984cited by this paper
• Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

  1984cited by this paper
• Effect of glutathione levels, sulfate levels, and metabolic inhibitors on covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-acetylaminofluorene to cell macromolecules in primary monolayer cultures of adult rat hepatocytes.

  1984cited by this paper
• Evidence that the Yb subunits of hepatic glutathione transferases represent two different but related families of polypeptides.

  1983cited by this paper
• Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate.

  1983cited by this paper
• Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases.

  1983cited by this paper
• Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.

  1981cited by this paper
• Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido [1,2-a:3',2'-d]imidazole and its reaction with DNA.

  1980cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Multi-DNA Adduct and Abasic Site Quantitation In Vivo by Nano-Liquid Chromatography/High-Resolution Orbitrap Tandem Mass Spectrometry: Methodology for Biomonitoring Colorectal DNA Damage.

  2022cites this paper
• Metabolism and biomarkers of heterocyclic aromatic amines in humans

  2021cites this paper
• Sub-chronic exposure to PhIP induces oxidative damage and DNA damage, and disrupts the amino acid metabolism in the colons of Wistar rats.

  2021cites this paper
• A review of recent advances in non-enzymatic electrochemical creatinine biosensing.

  2021cites this paper
• Promoter methylation and Ile105val polymorphism of GSTP1 gene in the modulation of colorectal cancer risk in ethnic Kashmiri population

  2019cites this paper
• 6-phenylimidazo(4,5-b)pyridine and 2-Amino-3,8-dimethylimidazo(4,5-J)quinoxaline in Humans: Relationship to Cytochrome P45OiA2 and N-Acetyltransferase Activity'

  2017cites this paper
• Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens.

  2017cites this paper
• Intégrer les échelles moléculaires et cellulaires dans l'inférence de réseaux métaboliques : application aux xénobiotiques. (Integrate molecular and cellular scales in the inference of metabolic networks : application to xenobiotics)

  2017influential citation
• Does Val/Val genotype of GSTP1 enzyme affects susceptibility to colorectal cancer in Saudi Arabia?.

  2016influential citation
• Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans.

  2015cites this paper
• Effect of Thermal Treatment on Meat Proteins with Special Reference to Heterocyclic Aromatic Amines (HAAs)

  2015cites this paper
• Impact of Xanthohumol on the DNA stability of human peripheral lymphocytes

  2013cites this paper
• Contributions of human enzymes in carcinogen metabolism.

  2012cites this paper
• Glutathione S‐transferase T1 and M1 (GSTT1, GSTM1) (genotyping) [Biomonitoring Methods, 2004]

  2012cites this paper
• Glutathion‐S‐Transferase T1 und M1 (Genotypisierung) [Biomonitoring Methods in German language, 2004]

  2012cites this paper
• GSTP1 I105V Polymorphism and Susceptibility to Colorectal Cancer in Kashmiri Population

  2012cites this paper
• Association of GSTM1, GSTT1, GSTP1 and CYP2E1 Single Nucleotide Polymorphisms with Colorectal Cancer in Iran

  2012cites this paper
• The GSTP1 Ile105Val polymorphism is not associated with susceptibility to colorectal cancer.

  2012cites this paper
• Genetic modification of the association of paraquat and Parkinson's disease

  2012cites this paper
• Dietary flavonoids as cancer-preventive and therapeutic

  2011influential citation
• La glutathion S-transferasa M1, el citocromo P450 1A1 y la epóxido hidrolasa como biomarcadores epidemiológicos de susceptibilidad genética de los cánceres de orofaringe

  2011cites this paper
• DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

  2011cites this paper
• Heterocyclic Aromatic Amines: Potential Human Carcinogens

  2011cites this paper
• Dietary flavonoids as cancer-preventive and therapeutic biofactors.

  2011cites this paper
• Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.

  2011cites this paper
• Chapter 2 – Heterocyclic Aromatic Amines: Potential Human Carcinogens

  2010cites this paper
• Aromatic Amines and Heterocyclic Aromatic Amines: From Tobacco Smoke to Food Mutagens

  2010cites this paper
• Impact of coffee consumption on DNA stability and redox status in humans

  2009cites this paper
• Effect of N -Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5- pyridine or 2-Amino-3,8-dimethylimidazo-[4,5-

  2009cites this paper
• Glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk: a meta-analysis and HuGE review.

  2009cites this paper
• Effect of N-Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline

  2009influential citation
• Anticarcinogenic Effects of Probiotics, Prebiotics, and Synbiotics

  2009cites this paper
• Polymorphisms of biotransforming enzymes (GSTs) and their association with colorectal cancer in the Slovak population.

  2009cites this paper
• The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.

  2008cites this paper
• Fruits and vegetables, detoxification genes and intermediate endpoints in colorectal cancer prevention

  2008cites this paper
• Heterocyclic Aromatic Amines

  2008cites this paper
• Role of GST and NAT2 polymorphisms in thyroid cancer

  2008cites this paper
• Enhanced glutathione S-transferase expression in 2-hydroxyamino- 1-methyl-6-phenylimidazo[4,5-b]pyridine-resistant IEC-18 cells

  2007influential citation
• Enhancement of phase II enzyme activity by purpurin resulting in the suppression of MeIQx-DNA-adduct formation in mice.

  2007cites this paper
• Novel LC-ESI/MS/MS(n) method for the characterization and quantification of 2'-deoxyguanosine adducts of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by 2-D linear quadrupole ion trap mass spectrometry.

  2007cites this paper
• 12 – Geontoxicity, metabolism, and biomarkers of heterocyclic aromatic amines

  2006cites this paper
• Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer.

  2006cites this paper
• [Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure].

  2006cites this paper
• The expression of xenobiotic‐metabolizing enzymes in human prostate and in prostate epithelial cells (PECs) derived from primary cultures

  2006cites this paper
• [Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure].

  2006cites this paper
• 16 – Metabolic factors affecting the mutagenicity of heterocyclic amines

  2006cites this paper
• Formation and biochemistry of carcinogenic heterocyclic aromatic amines in cooked meats.

  2006cites this paper
• Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population.

  2005cites this paper
• Dietary fibres as "prebiotics": implications for colorectal cancer.

  2005cites this paper
• Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk.

  2005cites this paper
• Expression of cytochromes P450 and glutathione S‐transferases in human prostate, and the potential for activation of heterocyclic amine carcinogens via acetyl‐coA‐, PAPS‐ and ATP‐dependent pathways

  2005cites this paper
• GSTP1 and GSTA1 Polymorphisms Interact with Cruciferous Vegetable Intake in Colorectal Adenoma Risk

  2005influential citation
• Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.

  2005cites this paper
• Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials.

  2005cites this paper
• Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessment.

  2005cites this paper
• Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).

  2005cites this paper
• Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

  2005cites this paper
• Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population

  2005cites this paper
• Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan.

  2005cites this paper
• Human Glutathione S-transferase A1 polymorphism and susceptibility to oral squamous cell carcinoma in Japanese

  2005cites this paper
• Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities

  2004cites this paper
• The Effect of Dietary Restriction on PhIP-Induced Mutation in the Distal Colon and B[a]P- and ENU-Induced Mutation in the Liver of the Rat

  2004cites this paper
• The role of genetic polymorphisms in metabolism of carcinogenic heterocyclic aromatic amines.

  2004cites this paper
• Association between Helicobacter pylori seropositivity and NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism observed in outpatients and health checkup examinees

  2004cites this paper
• Nutrition and colorectal cancer

  2004cites this paper
• Formation and analysis of heterocyclic aromatic amine-DNA adducts in vitro and in vivo.

  2004cites this paper
• Colon cancer risk factors from nutrition

  2004cites this paper
• Enzyme polymorphisms influencing the metabolism of heterocyclic aromatic amines.

  2004cites this paper
• Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer.

  2004cites this paper
• Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis.

  2004cites this paper
• The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.

  2003cites this paper
• Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation.

  2003cites this paper
• Glutathione S-transferase polymorphisms in thyroid cancer patients.

  2003cites this paper
• Effect of Dietary Constituents With Chemopreventive Potential on Adduct Formation of a Low Dose of the Heterocyclic Amines PhIP and IQ and Phase II Hepatic Enzymes

  2003cites this paper
• N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer.

  2003cites this paper
• Detection of polymorphism in xenobiotic metabolising enzymes using database analysis

  2003cites this paper
• Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

  2003cites this paper
• Genetic polymorphisms and modulation of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐DNA adducts in human lymphocytes

  2003cites this paper
• Phenotyping of human glutathione S-transferase hGSTT1-1: a comparison of two ex vivo routine procedures

  2002cites this paper
• Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.

  2002cites this paper
• Human prostate epithelial cells metabolize chemicals of dietary origin to mutagens.

  2002cites this paper
• Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.

  2002cites this paper
• Low-penetrance genes and their involvement in colorectal cancer susceptibility.

  2002influential citation
• Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.

  2002cites this paper
• HETEROCYCLIC AROMATIC AMINE METABOLISM, DNA ADDUCT FORMATION, MUTAGENESIS, AND CARCINOGENESIS

  2002cites this paper
• 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridin e(PhIP)- Induced Mutagenesi si nCulture dBi gBlue ™Rat Mammar yEpithelia lan dFibroblas tCells

  2002cites this paper
• Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.

  2002cites this paper
• 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells

  2002influential citation
• Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.

  2002cites this paper
• Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.

  2002cites this paper
• Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol

  2002cites this paper
• Mammary gland carcinogenesis by food‐derived heterocyclic amines: Metabolism and additional factors influencing carcinogenesis by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)

  2002cites this paper
• Aktivität der N-Acetyltransferase NAT1 und NAT2 in menschlichen Geweben

  2001influential citation
• Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.

  2001cites this paper
• Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

  2001cites this paper
• Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts.

  2001cites this paper
• The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk.

  2001cites this paper
• Effect of onion consumption by rats on hepatic drug-metabolizing enzymes.

  2001cites this paper
• A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.

  2001cites this paper
• Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression.

  2001cites this paper