Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed IκB Kinase Activation

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Biology

• Publication date

  2013-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01416-12PMID 23459942PMCID PMC3647962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No one can whistle a symphony alone – how different ubiquitin linkages cooperate to orchestrate NF-κB activity

  2012cited by this paper
• IAPs limit activation of RIP kinases by TNF receptor 1 during development

  2012cited by this paper
• HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling

  2011cited by this paper
• TNFR1‐induced activation of the classical NF‐κB pathway

  2011cited by this paper
• In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*

  2011cited by this paper
• cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)

  2011cited by this paper
• Linear ubiquitination prevents inflammation and regulates immune signalling

  2011cited by this paper
• RIPK1 is not essential for TNFR1-induced activation of NF-κB

  2010influential reference
• SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2

  2010cited by this paper
• Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

  2010cited by this paper
• c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

  2010cited by this paper
• The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

  2010cited by this paper
• Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

  2009cited by this paper
• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

  2009cited by this paper
• Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

  2009cited by this paper
• TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.

  2009cited by this paper
• Nonproteolytic functions of ubiquitin in cell signaling.

  2009influential reference
• Breaking the chains: structure and function of the deubiquitinases

  2009cited by this paper
• Regulation and function of NF-kappaB transcription factors in the immune system.

  2009cited by this paper
• TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

  2009cited by this paper
• Involvement of linear polyubiquitylation of NEMO in NF-κB activation

  2009cited by this paper
• Linear polyubiquitination: a new regulator of NF‐κB activation

  2009cited by this paper
• A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

  2009cited by this paper
• Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

  2009influential reference
• Control of canonical NF-κB activation through the NIK–IKK complex pathway

  2008cited by this paper
• TRAF2 Phosphorylation Modulates Tumor Necrosis Factor Alpha-Induced Gene Expression and Cell Resistance to Apoptosis

  2008cited by this paper
• c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

  2008cited by this paper
• Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

  2008cited by this paper
• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

  2006cited by this paper
• Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

  2006cited by this paper
• Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

  2006cited by this paper
• Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

  2006cited by this paper
• Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.

  2006cited by this paper
• Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF‐κB

  2004cited by this paper
• Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.

  2003cited by this paper
• Genetic analysis of NF‐κB/Rel transcription factors defines functional specificities

  2003cited by this paper
• Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses.

  2003cited by this paper
• Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death

  2002cited by this paper
• The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation.

  2002cited by this paper
• Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death*

  2001cited by this paper
• Two Waves of Nuclear Factor κb Recruitment to Target Promoters

  2001cited by this paper
• The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.

  2001cited by this paper
• RING finger proteins: mediators of ubiquitin ligase activity.

  2000cited by this paper
• The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.

  1998cited by this paper
• The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

  1998cited by this paper
• RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.

  1996cited by this paper
• Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

  1991influential reference
• The I (cid:1) B –NF-(cid:1) B Signaling Module: Temporal Control and Selective Gene Activation

  year unknowncited by this paper

• TAK1 at the crossroads of multiple regulated cell death pathways: from molecular mechanisms to human diseases

  2025cites this paper
• Cytokine-Driven NF-κB Activation in Retinal Cells and Its Impact on the Pathogenesis of Age-Related Macular Degeneration: A Systematic Review

  2024cites this paper
• Arteannuin B, a sesquiterpene lactone from Artemisia annua, attenuates inflammatory response by inhibiting the ubiquitin-conjugating enzyme UBE2D3-mediated NF-κB activation.

  2023cites this paper
• Global publication trends and research trends of necroptosis application in tumor: A bibliometric analysis

  2023cites this paper
• ROS Induced by Streptococcus agalactiae Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano Trachinotus ovatus (Linnaeus, 1758)

  2022cites this paper
• Regulated Cell Death in Urinary Malignancies

  2021cites this paper
• Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation

  2021cites this paper
• The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

  2020cites this paper
• TNFR2 is required for RIP1-dependent cell death in human leukemia.

  2020cites this paper
• TNFR1 membrane reorganization promotes distinct modes of TNFα signaling

  2019cites this paper
• Post-translational modification of the death receptor complex as a potential therapeutic target in cancer

  2019cites this paper
• Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

  2019cites this paper
• α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development.

  2019cites this paper
• Recent advances in understanding inhibitor of apoptosis proteins

  2018cites this paper
• The Many Roles of Ubiquitin in NF-κB Signaling

  2018cites this paper
• TNF&agr; in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases

  2018cites this paper
• The Role of RIPK1 Kinase Activity in Regulating Inflammation and Necroptotic Death

  2018cites this paper
• ACTN4 regulates the stability of RIPK1 in melanoma

  2018cites this paper
• Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

  2018cites this paper
• NEMO Links Nuclear Factor-κB to Human Diseases.

  2017cites this paper
• Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling

  2017cites this paper
• IAPs and Cell Death.

  2017cites this paper
• Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

  2017influential citation
• Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism

  2017cites this paper
• St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells.

  2016cites this paper
• More to Life than NF-κB in TNFR1 Signaling.

  2016cites this paper
• ST. JOHN's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells.

  2016cites this paper
• Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-κB in a Time and Dose Dependent Manner

  2016cites this paper
• Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFα Responses

  2016cites this paper
• TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice

  2016cites this paper
• Receptor-interacting protein-1 promotes the growth and invasion in gastric cancer.

  2016cites this paper
• RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer.

  2016cites this paper
• GENETIC AND PHARMACOLOGIC INHIBITION OF CELLULAR INHIBITOR OF APOPTOSIS 1 (cIAP1) PROTEIN EXPRESSION PROTECTS AGAINST DENERVATION-INDUCED SKELETAL MUSCLE ATROPHY IN VIVO

  2016cites this paper
• Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 are Increased after Labour in Foetal Membranes and Myometrium and are Essential for TNF‐α‐Induced Expression of Pro‐Labour Mediators

  2015cites this paper
• NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

  2015cites this paper
• TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

  2015cites this paper
• Molecular crosstalk between apoptosis, necroptosis, and survival signaling

  2015cites this paper
• IAPs, regulators of innate immunity and inflammation.

  2015cites this paper
• RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival

  2015cites this paper
• RIP1 Kinase Is an Oncogenic Driver in Melanoma.

  2015cites this paper
• TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways.

  2015cites this paper
• Sphingolipid metabolites in inflammatory disease

  2014cites this paper
• IAPs and Necroptotic Cell Death

  2014cites this paper
• IAP family of cell death and signaling regulators.

  2014cites this paper
• Regulation of NF-κB by TNF family cytokines.

  2014cites this paper
• TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.

  2013cites this paper
• Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

  2013cites this paper