RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Current Cancer Drug Targets

• Publication date

  2016-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/1568009616666151112122801PMID 26560116
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting the ubiquitin pathway for cancer treatment.

  2015cited by this paper
• IAP antagonization promotes inflammatory destruction of vascular endothelium

  2015cited by this paper
• Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles

  2015cited by this paper
• Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.

  2015cited by this paper
• Identification of HERC5 and its potential role in NSCLC progression

  2015cited by this paper
• A recurrent mutation in PARK2 is associated with familial lung cancer.

  2015cited by this paper
• PINK1/Parkin-mediated mitophagy in mammalian cells.

  2015cited by this paper
• Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response*

  2015cited by this paper
• NEDD4: The founding member of a family of ubiquitin-protein ligases.

  2015cited by this paper
• The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC‐1β

  2015cited by this paper
• Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects.

  2014cited by this paper
• Overexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma

  2014cited by this paper
• TRIM24 links glucose metabolism with transformation of human mammary epithelial cells

  2014cited by this paper
• HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

  2014cited by this paper
• Apoptosis and Molecular Targeting Therapy in Cancer

  2014cited by this paper
• HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.

  2014cited by this paper
• PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

  2014cited by this paper
• SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

  2014cited by this paper
• Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase

  2014cited by this paper
• RBR E3 ubiquitin ligases: new structures, new insights, new questions

  2014cited by this paper
• TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway

  2014cited by this paper
• Association between single nucleotide polymorphisms in the p53 pathway and response to radiotherapy in patients with nasopharyngeal carcinoma.

  2014cited by this paper
• Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer

  2014cited by this paper
• The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling

  2014cited by this paper
• Tumour suppressor TRIM33 targets nuclear β-catenin degradation

  2014cited by this paper
• Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

  2014cited by this paper
• Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair

  2014cited by this paper
• Signalling: Loss of Cbl-b unleashes anti-metastatic natural killer cells

  2014cited by this paper
• Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

  2014cited by this paper
• Degradation of the Deubiquitinating Enzyme USP33 Is Mediated by p97 and the Ubiquitin Ligase HERC2*

  2014cited by this paper
• RBR E3‐ligases at work

  2014cited by this paper
• Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

  2014cited by this paper
• RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

  2014cited by this paper
• p28, A first in class peptide inhibitor of cop1 binding to p53

  2013cited by this paper
• MDM2, MDMX and p53 in oncogenesis and cancer therapy

  2013cited by this paper
• Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function

  2013cited by this paper
• The Many Faces of TRAF Molecules in Immune Regulation

  2013cited by this paper
• E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin

  2013cited by this paper
• Smurf E3 ubiquitin ligases at the cross roads of oncogenesis and tumor suppression.

  2013cited by this paper
• Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed IκB Kinase Activation

  2013cited by this paper
• Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

  2013cited by this paper
• Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

  2013cited by this paper
• The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

  2013cited by this paper
• RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development

  2013cited by this paper
• Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.

  2013cited by this paper
• The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance

  2013cited by this paper
• The tripartite motif: structure and function.

  2012cited by this paper
• Targeting IAP proteins for therapeutic intervention in cancer

  2012cited by this paper
• The histone deacetylase SIRT2 stabilizes Myc oncoproteins

  2012cited by this paper
• Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms

  2012cited by this paper
• Decreased Tonic Inhibition in Cerebellar Granule Cells Causes Motor Dysfunction in a Mouse Model of Angelman Syndrome

  2012cited by this paper
• Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.

  2012cited by this paper
• Biological influence of Hakai in cancer: a 10-year review

  2012cited by this paper
• Pirh2 RING‐finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

  2012cited by this paper
• MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer

  2012cited by this paper
• Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.

  2012cited by this paper
• TRAF6 activation in multiple myeloma: a potential therapeutic target.

  2012cited by this paper
• Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.

  2012cited by this paper
• HECT and RING finger families of E3 ubiquitin ligases at a glance

  2012cited by this paper
• Spotlight on the role of COP1 in tumorigenesis

  2012cited by this paper
• Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

  2012cited by this paper
• The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

  2012cited by this paper
• LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

  2012cited by this paper
• Linear ubiquitination: a novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.

  2012cited by this paper
• COP1 is a tumour suppressor that causes degradation of ETS transcription factors

  2011cited by this paper
• PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.

  2011cited by this paper
• SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

  2011cited by this paper
• MDM2 and MDMX in cancer and development.

  2011cited by this paper
• Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors

  2011cited by this paper
• Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia.

  2011cited by this paper
• TRIM proteins and cancer

  2011cited by this paper
• Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

  2011cited by this paper
• Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

  2011cited by this paper
• Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.

  2011cited by this paper
• An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

  2011cited by this paper
• HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression.

  2011cited by this paper
• Tripartite-motif proteins and innate immune regulation.

  2011cited by this paper
• A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20

  2011cited by this paper
• Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

  2011cited by this paper
• Good COP1 or bad COP1? In vivo veritas.

  2011cited by this paper
• Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer.

  2011cited by this paper
• Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

  2011cited by this paper
• Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP

  2011cited by this paper
• The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function

  2011cited by this paper
• A novel oncoprotein Pirh2: rising from the shadow of MDM2

  2011cited by this paper
• Linear ubiquitination prevents inflammation and regulates immune signalling

  2011cited by this paper
• The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

  2011cited by this paper
• 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.

  2011cited by this paper
• Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.

  2010cited by this paper
• The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation

  2010cited by this paper
• NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity

  2010cited by this paper
• Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

  2010cited by this paper
• The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

  2010cited by this paper
• KAP1 Is Associated With Peritoneal Carcinomatosis in Gastric Cancer

  2010cited by this paper
• Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

  2010cited by this paper
• Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

  2010cited by this paper
• PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

  2010cited by this paper
• E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erbα

  2010cited by this paper
• The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

  2010cited by this paper
• Genomic instability — an evolving hallmark of cancer

  2010cited by this paper

• Cis or trans: a puzzle of Parkin activation mechanism.

  2026cites this paper
• Allosteric zinc inhibition and interdomain regulation govern the catalytic mechanism of the E3-independent ubiquitin-conjugating enzyme hUBE2O

  2025cites this paper
• The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers

  2025cites this paper
• UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions

  2025cites this paper
• The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

  2025cites this paper
• Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O

  2025cites this paper
• The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

  2025cites this paper
• CBLB Regulates MAPK‐P38 Pathway via MAP3K9 Ubiquitination to Inhibit GBM Cell Invasion and Migration

  2025cites this paper
• Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders

  2025cites this paper
• E3 ubiquitin ligases and their therapeutic potential in disease Management.

  2025cites this paper
• Computational studies on the functional and structural impact of pathogenic mutations in enzymes

  2025cites this paper
• PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy

  2024cites this paper
• RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection

  2024cites this paper
• E3 ubiquitin ligases: key regulators of osteogenesis and potential therapeutic targets for bone disorders

  2024cites this paper
• E3 ubiquitin ligases and deubiquitinases in colorectal cancer: Emerging molecular insights and therapeutic opportunities.

  2024cites this paper
• Ubiquitination contributes to the regulation of GDP-mannose pyrophosphorylase B activity

  2024cites this paper
• Strategic advancement of E3 ubiquitin ligase in the management of hepatocellular carcinoma

  2024cites this paper
• Multiple Transgenic Strategies Positively Regulate Cold-Induced Sweetening in Low Temperature Stored Potato Tubers

  2024cites this paper
• ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans

  2024cites this paper
• Novel Therapeutic Avenues for Hypertrophic Cardiomyopathy

  2023cites this paper
• RNF144A promotes antiviral responses by modulating STING ubiquitination

  2023cites this paper
• The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN

  2023cites this paper
• Modulation of Ubiquitin Signaling in Innate Immune Response by Herpesviruses

  2022cites this paper
• Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins

  2022cites this paper
• Rice SIAH E3 Ligases Interact with RMD Formin and Affect Plant Morphology

  2022influential citation
• RNF144A exerts tumor suppressor function in breast cancer through targeting YY1 for proteasomal degradation to downregulate GMFG expression

  2022cites this paper
• Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells

  2022cites this paper
• ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

  2022influential citation
• TRIM-NHL as RNA binding Ubiquitin E3 Ligase (RBUL): Implication in development and disease pathogenesis.

  2021cites this paper
• Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges

  2021cites this paper
• Molecular Insights into the Roles of E3-Ligases in ROS-Mediated Cancer from a Bioinformatics Perspective

  2021cites this paper
• Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis

  2021cites this paper
• Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs

  2021cites this paper
• The emerging role of WWP1 in cancer development and progression

  2021cites this paper
• NtRNF217, Encoding a Putative RBR E3 Ligase Protein of Nicotiana tabacum, Plays an Important Role in the Regulation of Resistance to Ralstonia solanacearum Infection

  2021cites this paper
• Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer

  2021cites this paper
• E3 Ubiquitin Ligase in Anticancer Drugdsla Resistance: Recent Advances and Future Potential

  2021cites this paper
• A mechanistic review of Parkin activation.

  2021cites this paper
• RBR E3 ubiquitin ligases in tumorigenesis.

  2020cites this paper
• Functional roles of E3 ubiquitin ligases in gastric cancer

  2020cites this paper
• Unstructured Biology of Proteins from Ubiquitin-Proteasome System: Roles in Cancer and Neurodegenerative Diseases

  2020cites this paper
• A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis

  2020cites this paper
• Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target

  2019cites this paper
• SUMOylation and Ubiquitination

  2019cites this paper
• Cracking the Ubiquitin Code: The Ubiquitin Toolbox.

  2019cites this paper
• RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

  2019cites this paper
• Identification of an E3 ligase-encoding gene RFWD3 in non-small cell lung cancer

  2019cites this paper
• Kelch-like proteins: physiological functions and relationships with diseases.

  2019cites this paper
• Novel Nanomaterials for Protein Analysis

  2019cites this paper
• Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer

  2019cites this paper
• Ubiquitin‐proteasome signaling in lung injury

  2018cites this paper
• A patent review of the ubiquitin ligase system: 2015–2018

  2018cites this paper
• E3 ubiquitin ligases in cancer and implications for therapies

  2017cites this paper
• RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells

  2017influential citation
• Elevated Hapln2 Expression Contributes to Protein Aggregation and Neurodegeneration in an Animal Model of Parkinson's Disease

  2016influential citation