Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2011-07-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1102241108PMID 21730132PMCID PMC3141986
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

  2011cited by this paper
• Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.

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  2009cited by this paper
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  2008cited by this paper
• Loss of Mdm4 Results in p53-Dependent Dilated Cardiomyopathy

  2007cited by this paper
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  2007cited by this paper
• High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

  2007cited by this paper
• Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.

  2007cited by this paper
• Haploinsufficiency of Mdm2 and Mdm4 in Tumorigenesis and Development

  2007cited by this paper
• Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4

  2006cited by this paper
• Inactivation of the p53 pathway in retinoblastoma

  2006cited by this paper
• ATM and Chk2‐dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

  2005cited by this paper
• Significance of HDMX‐S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis

  2005cited by this paper
• Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

  2004cited by this paper
• DNA Damage-induced MDMX Degradation Is Mediated by MDM2*

  2003cited by this paper
• MDM2 Promotes Ubiquitination and Degradation of MDMX

  2003cited by this paper
• Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target

  2003cited by this paper
• Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53*

  2002cited by this paper
• mdmx is a negative regulator of p53 activity in vivo.

  2002cited by this paper
• DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms

  2002cited by this paper
• Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

  2002cited by this paper
• Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

  2001cited by this paper
• MdmX Protects p53 from Mdm2-Mediated Degradation

  2000cited by this paper
• Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

  1999cited by this paper
• MDM2 interacts with MDMX through their RING finger domains

  1999cited by this paper
• A Novel MDMX Transcript Expressed in a Variety of Transformed Cell Lines Encodes a Truncated Protein with Potent p53 Repressive Activity*

  1999cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
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• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• Mdm2 promotes the rapid degradation of p53

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  1996cited by this paper
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  1995cited by this paper
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• Physical and functional interaction between wild-type p53 and mdm2 proteins

  1994cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper

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• A Dual-Specificity d-Peptide Antagonist of MDM2 and MDMX for Antitumor Immunotherapy.

  2025cites this paper
• Dependence on Mdm2 for Mdm4 inhibition of p53 activity.

  2025cites this paper
• Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells.

  2024cites this paper
• Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation

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• Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq

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• Tissue specificity and spatio-temporal dynamics of the p53 transcriptional program

  2023cites this paper
• FAM193A is a positive regulator of p53 activity

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• Dual Targeting of MDM4 and FTH1 by MMRi71 for Induced Protein Degradation and p53-Independent Apoptosis in Leukemia Cells

  2022cites this paper
• The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review.

  2022cites this paper
• MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

  2022cites this paper
• p53-mediated metabolic response to low doses of ionizing radiation

  2022cites this paper
• MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

  2022cites this paper
• Alterations of the MDM2 C-terminus differentially impact its function in vivo.

  2022cites this paper
• MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail

  2021cites this paper
• Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation

  2021cites this paper
• The p53-p21 axis plays a central role in lymphatic homeostasis and disease

  2021cites this paper
• Mdm2 and MdmX: Partners in p53 Destruction

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• Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

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• Stability of p53 oligomers: Tetramerization of p53 impinges on its stability.

  2021cites this paper
• Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.

  2021cites this paper
• Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells

  2020cites this paper
• MDM2’s dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities

  2020cites this paper
• The MDM2/MDMX/p53 axis in the adaptive stress response

  2020cites this paper
• MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo

  2020cites this paper
• Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

  2020cites this paper
• The long and the short of it: the MDM4 tail so far

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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

  2017cites this paper
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  2017cites this paper
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• The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis

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• Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice

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  2017cites this paper
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• Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.

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• The Effects of SUMO modification of the Tumour Suppressor p53

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• The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation

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• Modulation of p53 signalling and response to MDM2-p53 binding antagonists

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• Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies.

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• IN VIVO SIGNIFICANCE OF THE MDM4 AND P73 INTERACTION DURING DEVELOPMENT AND TUMORIGENESIS

  2015cites this paper
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• The Mdm Network and Its Regulation of p53 Activities: A Rheostat of Cancer Risk

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• The role of ubiquitin modification in the regulation of p53.

  2014cites this paper
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