The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function

A large number of RING finger (RNF) proteins are present in eukaryotic cells and the majority of them are believed to act as E3 ubiquitin ligases. In humans, 49 RNF proteins are predicted to contain transmembrane domains, several of which are specifically localized to membrane compartments in the secretory and endocytic pathways, as well as to mitochondria and peroxisomes. They are thought to be molecular regulators of the organization and integrity of the functions and dynamic architecture of cellular membrane and membranous organelles. Emerging evidence has suggested that transmembrane RNF proteins control the stability, trafficking and activity of proteins that are involved in many aspects of cellular and physiological processes. This review summarizes the current knowledge of mammalian transmembrane RNF proteins, focusing on their roles and significance.

• Publication year

  2011

• Venue

  Membranes

• Publication date

  2011-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/membranes1040354PMID 24957874PMCID 4021871
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Emerging evidence indicates that transmembrane RING finger proteins control the stability, trafficking, and activity of proteins involved in diverse cellular and physiological processes.

  Confidence 0.89

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• Mammalian transmembrane RING finger proteins are described as being localized to membrane compartments in the secretory and endocytic pathways, as well as to mitochondria and peroxisomes.

  Confidence 0.91

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• Transmembrane RING finger proteins are positioned as molecular regulators of the organization and integrity of cellular membrane and membranous organelles.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

• cellular membrane and membranous organelles

  cellular structure

  The cellular membranes and membrane-bound organelles whose organization and integrity are discussed in relation to this protein family.

  Aliases: membrane and membranous organelles

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• mitochondria

  organelle

  Energy-producing membrane-bound organelles that are mentioned as one localization site for these proteins.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• peroxisomes

  organelle

  Membrane-bound organelles involved in oxidative metabolism that are mentioned as one localization site for these proteins.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• protein stability, trafficking and activity

  cellular process

  The set of protein-level properties and processes that are discussed as regulatory targets of transmembrane RING finger proteins.

  Aliases: protein stability, protein trafficking, protein activity

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• secretory and endocytic pathways

  cellular pathway

  The membrane-trafficking routes that move proteins and lipids through secretion, uptake, and intracellular sorting.

  Aliases: secretory pathway, endocytic pathway

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review
• transmembrane ring finger proteins

  protein family

  A subgroup of RING finger proteins predicted to contain transmembrane domains and to reside in membrane-associated cellular compartments.

  Aliases: RNF proteins, transmembrane RNF proteins

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) review

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