The Control of β-catenin and TCF During Embryonic Development and Cancer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cancer Metastasis Review

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/A:1006321324190
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• E-Cadherin and APC Compete for the Interaction with -Catenin and the Cytoskeleton

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  2000cited by this paper
• An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐catenin

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  1999cited by this paper
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• Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.

  1999cited by this paper
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  1999cited by this paper
• The C-terminal transactivation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis

  1999cited by this paper
• The C‐terminal domain of Armadillo binds to hypophosphorylated Teashirt to modulate Wingless signalling in Drosophila

  1999cited by this paper
• The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

  1999cited by this paper
• Wnt3a−/−-like phenotype and limb deficiency in Lef1−/−Tcf1−/− mice

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• Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

  1999cited by this paper
• The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

  1999cited by this paper
• Interaction of Axin and Dvl‐2 proteins regulates Dvl‐2‐stimulated TCF‐dependent transcription

  1999cited by this paper
• Axin, an inhibitor of the Wnt signaling pathway, interacts with β-catenin, GSK-3 β and APC and reduces the β-catenin level

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• The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro

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• The cyclin D1 gene is a target of the b-cateninyLEF-1 pathway

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• A function of CBP as a transcriptional co‐activator during Dpp signalling

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• β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

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• Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier

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• Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

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• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

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• Axin prevents Wnt-3a-induced accumulation of β-catenin

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• Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.

  1998influential reference
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• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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• Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

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• Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

  1998cited by this paper
• The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

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• Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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• Drosophila Tcf and Groucho interact to repress Wingless signalling activity

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• Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

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• TCF: transcriptional activator or repressor?

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• Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

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• Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

  1998cited by this paper
• Function of zebrafish β-catenin and TCF-3 in dorsoventral patterning

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• GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.

  1998cited by this paper
• Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

  1998cited by this paper
• A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.

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• Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

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• TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

  1998cited by this paper
• Transcriptional repression due to high levels of Wingless signalling

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling.

  1998cited by this paper
• The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.

  1998cited by this paper
• Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

  1998cited by this paper
• Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin

  1998cited by this paper
• Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome.

  1998cited by this paper
• Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin*

  1998cited by this paper
• Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

  1998cited by this paper
• Physical and Functional Interaction of SMADs and p300/CBP*

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter.

  1997cited by this paper
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• Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

  1997cited by this paper
• Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

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• Endoderm induction in Drosophila: the nuclear targets of the inducing signals.

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• 腺腫性結腸ポリープ癌抑制遺伝子のショウジョウバエ相同体はβ‐カテニンをダウンレギュレートするが,その接合体発現はアルマジロ蛋白質の調節に必須ではない

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• Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro.

  1997cited by this paper
• Negative regulation of Armadillo, a Wingless effector in Drosophila.

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• β‐catenin is a target for the ubiquitin–proteasome pathway

  1997cited by this paper
• Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

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• LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

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• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.

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• A CREB‐binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

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• The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

  1997cited by this paper
• TCF/LEF factor earn their wings.

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• The adenomatous polyposis coli (APC) tumor suppressor.

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• Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

  1997cited by this paper
• The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer.

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• Epithelial differentiation in Drosophila

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• Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin*

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• A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo.

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