Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

Pedro Monteiro,Carine Rossé,Antonio Castro-Castro,M. Irondelle,E. Lagoutte,P. Paul-Gilloteaux,C. Desnos,E. Formstecher,F. Darchen,D. Perrais,A. Gautreau,Maud Hertzog,P. Chavrier

Published 2013 in Journal of Cell Biology

ABSTRACT

WASH and exocyst promote pericellular matrix degradation and tumor cell invasion by enabling localized exocytosis of MT1-MMP from late endosomes.

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