Lithium in the Kidney: Friend and Foe?

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of the American Society of Nephrology

• Publication date

  2016-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1681/ASN.2015080907PMID 26577775PMCID PMC4884121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-Term Lithium Use and Risk of Renal and Upper Urinary Tract Cancers.

  2016cited by this paper
• Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.

  2015cited by this paper
• Integrated control of Na transport along the nephron.

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• Effects of 10 to 30 years of lithium treatment on kidney function

  2015cited by this paper
• Targeting renal purinergic signalling for the treatment of lithium‐induced nephrogenic diabetes insipidus

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• Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells.

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• Clopidogrel attenuates lithium-induced alterations in renal water and sodium channels/transporters in mice

  2015cited by this paper
• Glycogen synthase kinase 3β dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathy.

  2014cited by this paper
• End-stage renal disease associated with prophylactic lithium treatment.

  2014cited by this paper
• Delayed administration of a single dose of lithium promotes recovery from AKI.

  2014cited by this paper
• Lithium and renal tumors: a critical comment to the report by Zaidan et al.

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Fine-tuning of NFκB by Glycogen Synthase Kinase 3β directs the fate of glomerular podocytes upon injury

  2014cited by this paper
• Lithium causes G2 arrest of renal principal cells.

  2014cited by this paper
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  2014cited by this paper
• A new alpha in line between KRAS and NF-κB activation?

  2013cited by this paper
• Role of Nrf2 in protection against acute kidney injury.

  2013cited by this paper
• Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells.

  2013cited by this paper
• Is there a role for PGE2 in urinary concentration?

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium.

  2013cited by this paper
• The prevalence and management of side effects of lithium and anticonvulsants as mood stabilizers in bipolar disorder from a clinical perspective: a review

  2013cited by this paper
• Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury.

  2013cited by this paper
• Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens

  2012cited by this paper
• Glycogen synthase kinase-3 regulation of urinary concentrating ability

  2012cited by this paper
• Lithium reduces aquaporin-2 transcription independent of prostaglandins.

  2012cited by this paper
• Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

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• Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

  2012cited by this paper
• Oxidative stress, anti‐oxidant therapies and chronic kidney disease

  2012cited by this paper
• Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase-3β-positive epithelium.

  2012cited by this paper
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• Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

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• Solid renal tumours of collecting duct origin in patients on chronic lithium therapy

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• Low-dose lithium uptake promotes longevity in humans and metazoans

  2011cited by this paper
• Effects of lithium on oxidative stress parameters in healthy subjects.

  2011cited by this paper
• Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.

  2011cited by this paper
• alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.

  2011cited by this paper
• Antidepressant‐like responses to lithium in genetically diverse mouse strains

  2011cited by this paper
• Renal failure occurs in chronic lithium treatment but is uncommon.

  2010cited by this paper
• NF-kappaB in renal inflammation.

  2010cited by this paper
• GSK3beta promotes apoptosis after renal ischemic injury.

  2010cited by this paper
• GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.

  2010cited by this paper
• Chronic lithium treatment protects the rat kidney against ischemia/reperfusion injury: the role of nitric oxide and cyclooxygenase pathways.

  2010cited by this paper
• Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

  2010cited by this paper
• Lithium induced interstitial nephropathy associated with chronic renal failure. Reversibility and correlation between functional and structural changes.

  2009cited by this paper
• Interstitial focal fibrosis and reduction in proximal tubular length in adult rats after lithium treatment.

  2009cited by this paper
• Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells.

  2009cited by this paper
• Mice lacking mPGES-1 are resistant to lithium-induced polyuria.

  2009cited by this paper
• Inhibiting glycogen synthase kinase‐3 reduces endotoxaemic acute renal failure by down‐regulating inflammation and renal cell apoptosis

  2009cited by this paper
• Wnt/beta-catenin signaling promotes renal interstitial fibrosis.

  2009cited by this paper
• Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.

  2009cited by this paper
• Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

  2009cited by this paper
• Regulation of protein stability by GSK3 mediated phosphorylation

  2009cited by this paper
• Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.

  2008cited by this paper
• Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease.

  2008cited by this paper
• Wnt signaling and cancer development: therapeutic implication.

  2008cited by this paper
• GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.

  2008cited by this paper
• Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation

  2008cited by this paper
• GSK‐3β down‐regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

  2008cited by this paper
• Hepatocyte Growth Factor Suppresses Proinflammatory NFκB Activation through GSK3β Inactivation in Renal Tubular Epithelial Cells*

  2008cited by this paper
• CDK/GSK-3 inhibitors as therapeutic agents for parenchymal renal diseases.

  2008cited by this paper
• pVHL and GSK3β are components of a primary cilium-maintenance signalling network

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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• 1 GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITS THE XENOBIOTIC AND ANTIOXIDANT CELL RESPONSE BY DIRECT PHOSPHORYLATION AND NUCLEAR EXCLUSION OF THE TRANSCRIPTION FACTOR NRF 2 *

  2006cited by this paper
• Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct.

  2006cited by this paper
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  2006cited by this paper
• Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2*

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• Polarisation, key to good localisation.

  2006cited by this paper
• Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.

  2006cited by this paper
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  2005cited by this paper
• Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats

  2005cited by this paper
• Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria.

  2005cited by this paper
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  2005cited by this paper
• Lithium as an indicator of proximal sodium reabsorption

  2004cited by this paper
• Molecular effects of lithium.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.

  2004cited by this paper
• Chronic lithium nephropathy: MR imaging for diagnosis.

  2003cited by this paper
• GSK-3: tricks of the trade for a multi-tasking kinase

  2003cited by this paper
• Lithium-induced nephropathy: Rate of progression and prognostic factors.

  2003cited by this paper
• Lithium: Occurrence, Dietary Intakes, Nutritional Essentiality

  2002cited by this paper
• Lithium-induced nephrogenic diabetes insipidus.

  2001cited by this paper
• Transcription factor-kappa B (NF-kappa B) and renal disease.

  2001cited by this paper
• Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy.

  2000cited by this paper
• Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI.

  2000cited by this paper

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  2026cites this paper
• Lysine acetylation of aquaporin-3 does not improve lithium-induced nephrogenic diabetes insipidus.

  2025cites this paper
• Glycogen synthase kinase 3β: a key player in progressive chronic kidney disease

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• A reversible fluorescence probe enables bioimaging and toxicity evaluation of lithium ion in living human cells.

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• A Custom‐Built, Cost‐Efficient Lithium‐7 Tx/Rx Coil for In Vivo 7Li Magnetic Resonance Imaging and Spectroscopy

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• The effects of using lithium on biochemical factors of urinary beta-2 microglobulin, creatinine and urea serum in chronic bipolar patients

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• Low exposition to lithium prevents nephrogenic diabetes insipidus but not microcystic dilations of the collecting ducts in long‐term rat model

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• Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the Potential to Prevent or Correct Dysregulation of Systems during Aging and in Disease

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• Lithium in Drinking Water and its Potential Impact on Mental Health: A Review.

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• Ameliorative Effect of Chitosan Against Lithium Carbonate Subacute Toxicity on Kidney and Parathyroid Gland of Adult Male Albino Rats

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• Analysis of the Decrement of Renal Weights in Adult Male Rats after Long Term Lithium Carbonate Ingestion

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• Astaxanthin treatment reduces kidney damage and facilitates antioxidant recovery in lithium-intoxicated rats.

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  2023cites this paper
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• Age-related GSK3β overexpression drives podocyte senescence and glomerular aging

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