Im7 folding mechanism: misfolding on a path to the native state

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature Structural Biology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsb757PMID 11875516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9.

  2001cited by this paper
• Folding consensus?

  2001cited by this paper
• Structural and kinetic characterization of early folding events in beta-lactoglobulin.

  2001cited by this paper
• Structural and kinetic characterization of early folding events in β-lactoglobulin

  2001cited by this paper
• Keeping it in the family: folding studies of related proteins.

  2001cited by this paper
• Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate

  2001cited by this paper
• Preorganized secondary structure as an important determinant of fast protein folding

  2001cited by this paper
• Protein folding theory: from lattice to all-atom models.

  2001cited by this paper
• Transition states and the meaning of Φ-values in protein folding kinetics

  2001cited by this paper
• Mechanisms of protein folding.

  2001cited by this paper
• Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes.

  2000cited by this paper
• A surprising simplicity to protein folding

  2000cited by this paper
• Kinetics, thermodynamics and evolution of non-native interactions in a protein folding nucleus

  2000cited by this paper
• Hierarchical folding of cytochrome c.

  2000cited by this paper
• Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding.

  1999cited by this paper
• NOE data demonstrating a compact unfolded state for an SH3 domain under non-denaturing conditions.

  1999cited by this paper
• Folding dynamics of the B1 domain of protein G explored by ultrarapid mixing

  1999cited by this paper
• Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9.

  1999cited by this paper
• The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved

  1999cited by this paper
• Is protein folding hierarchic? I. Local structure and peptide folding.

  1999cited by this paper
• The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein.

  1999cited by this paper
• Confirmation of the hierarchical folding of RNase H: a protein engineering study

  1999cited by this paper
• Is protein folding hierarchic? II. Folding intermediates and transition states.

  1999cited by this paper
• The burst phase in ribonuclease A folding and solvent dependence of the unfolded state

  1998cited by this paper
• Specificity in protein-protein recognition: conserved Im9 residues are the major determinants of stability in the colicin E9 DNase-Im9 complex.

  1998cited by this paper
• Protein folding dynamics: quantitative comparison between theory and experiment.

  1998cited by this paper
• Contact order, transition state placement and the refolding rates of single domain proteins.

  1998cited by this paper
• Dual recognition and the role of specificity-determining residues in colicin E9 DNase-immunity protein interactions.

  1998cited by this paper
• Evidence for barrier-limited protein folding kinetics on the microsecond time scale

  1998cited by this paper
• A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity.

  1998cited by this paper
• Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters.

  1998cited by this paper
• How do small single-domain proteins fold?

  1998cited by this paper
• The early folding kinetics of apomyoglobin

  1998cited by this paper
• Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain

  1998cited by this paper
• Development of the multiple sequence approximation within the AGADIR model of alpha-helix formation: comparison with Zimm-Bragg and Lifson-Roig formalisms.

  1997cited by this paper
• Ultrafast signals in protein folding and the polypeptide contracted state.

  1997cited by this paper
• Raster3D: photorealistic molecular graphics.

  1997cited by this paper
• Kinetic role of early intermediates in protein folding.

  1997cited by this paper
• Protein-Protein Interaction Specificity of Im9 for the Endonuclease Toxin Colicin E9 Defined by Homologue-scanning Mutagenesis*

  1997cited by this paper
• The biology of E colicins: paradigms and paradoxes.

  1996cited by this paper
• Characterizing transition states in protein folding: an essential step in the puzzle.

  1995cited by this paper
• Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 2. Cognate and noncognate interactions that span the millimolar to femtomolar affinity range.

  1995cited by this paper
• Elucidating the folding problem of helical peptides using empirical parameters. II. Helix macrodipole effects and rational modification of the helical content of natural peptides.

  1995cited by this paper
• Elucidating the folding problem of helical peptides using empirical parameters. III. Temperature and pH dependence.

  1995cited by this paper
• Mapping the structures of transition states and intermediates in folding: delineation of pathways at high resolution.

  1995cited by this paper
• Elucidating the folding problem of helical peptides using empirical parameters

  1994cited by this paper
• Protein folding dynamics: The diffusion‐collision model and experimental data

  1994cited by this paper
• The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding.

  1992cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Protein-folding dynamics

  1976cited by this paper

• Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope.

  2026cites this paper
• EPIclip: A Novel Approach for the Production of Decorated Virus-Like Particles Mediated by High-Affinity Protein Binding Partners.

  2026cites this paper
• Catalyzing Protein Folding by Chaperones

  2025cites this paper
• Comprehensive perspective towards the management of proteinopathies by elucidating protein misfolding and aggregation.

  2023cites this paper
• Predicting protein folding pathway using a novel folding force field model derived from known protein universe

  2023cites this paper
• Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding, and function

  2023cites this paper
• Insights into the client protein release mechanism of the ATP-independent chaperone Spy

  2022cites this paper
• The folding and misfolding mechanisms of multidomain proteins

  2022cites this paper
• ATP-Independent Chaperones.

  2022cites this paper
• Effects of Surface Tethering on the Thermodynamics and Kinetics of Frustrated Protein Folding.

  2022cites this paper
• An enzyme-based biosensor for monitoring and engineering protein stability in vivo

  2021cites this paper
• Yeast tripartite biosensors sensitive to protein stability and aggregation propensity.

  2020cites this paper
• Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity

  2020cites this paper
• Chaperone action of a cofactor in protein folding

  2020cites this paper
• Successes and challenges in simulating the folding of large proteins

  2019cites this paper
• Stability and Strain in Hisactophilin and Mechanism of the Myristoyl Switch

  2019cites this paper
• Proteins: 'Boil 'Em, Mash 'Em, Stick 'Em in a Stew'.

  2019cites this paper
• The role of solvent quality and chain stiffness on the end-to-end contact kinetics of semiflexible polymers.

  2018cites this paper
• Mechanism of Folding and Binding of the N-Terminal SH2 Domain from SHP2.

  2018cites this paper
• Electrostatic interactions are important for chaperone-client interaction in vivo.

  2018cites this paper
• Folding Mechanism of the SH3 Domain from Grb2.

  2018cites this paper
• The mechanism of the ATP-independent periplasmic chaperone SurA in outer membrane protein biogenesis

  2018cites this paper
• Tit le The mechanisms of protein folding and motor dynamics embedded in structures : Coarse grained molecular simulat ion ( タンパク質立体構造 に内蔵された「折れたたみ」と「分子モーター機能発現」の仕組み : 粗視化モデルによる分子動力学シミュレーション ) 氏名

  2018cites this paper
• Effects of Non-native Interactions on Frustrated Proteins Folding under Confinement.

  2018cites this paper
• Complex Folding Landscape of Apomyoglobin at Acidic pH Revealed by Ultrafast Kinetic Analysis of Core Mutants.

  2018cites this paper
• Chaperone–substrate interactions monitored via a robust TEM-1 β-lactamase fragment complementation assay

  2017cites this paper
• How Many Protein Sequences Fold to a Given Structure? A Coevolutionary Analysis.

  2017influential citation
• Molecular recognition and packing frustration in a helical protein

  2017cites this paper
• Protein folding by NMR.

  2017cites this paper
• A Dry Transition State More Compact Than the Native State Is Stabilized by Non-Native Interactions during the Unfolding of a Small Protein.

  2017cites this paper
• Non-Native α-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the β-Barrel in β-Lactoglobulin.

  2017cites this paper
• Impact of Turn Propensity on the Folding Rates of Z34C Protein: Implications for the Folding of Helix-Turn-Helix Motif.

  2017cites this paper
• Microscopic interpretation of folding ϕ-values using the transition path ensemble

  2016cites this paper
• Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study

  2016cites this paper
• Folding Mechanism of Proteins Im7 and Im9: Insight from All-Atom Simulations in Implicit and Explicit Solvent.

  2016cites this paper
• Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain*

  2016cites this paper
• Forces Driving Chaperone Action Graphical

  2016cites this paper
• Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.

  2016cites this paper
• Using the folding landscapes of proteins to understand protein function.

  2016cites this paper
• A molecular mechanism of chaperone-client recognition

  2016cites this paper
• Testing the dependence of stabilizing effect of osmolytes on the fractional increase in the accessible surface area on thermal and chemical denaturations of proteins.

  2016cites this paper
• Molecular Mechanics Study of Protein Folding and Protein-Ligand Binding

  2016cites this paper
• Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants.

  2016cites this paper
• Forces Driving Chaperone Action.

  2016cites this paper
• Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar

  2015cites this paper
• Protein folding occurs while bound to the ATP-independent chaperone Spy

  2015cites this paper
• Rise of the Helix from a Collapsed Globule during the Folding of Monellin.

  2015cites this paper
• Native Contact Density and Nonnative Hydrophobic Effects in the Folding of Bacterial Immunity Proteins

  2015influential citation
• Dependence of Internal Friction on Folding Mechanism

  2015cites this paper
• Effects of macromolecular crowding on protein folding

  2015cites this paper
• Protein extraction using reverse micelles

  2015cites this paper
• Proteostasis and Chaperone Surveillance

  2015cites this paper
• Using hydroxyl radical footprinting to explore the free energy landscape of protein folding

  2015cites this paper
• Characterization of pre-molten globule state of yeast iso-1-cytochrome c and its deletants at pH 6.0 and 25 °C.

  2015cites this paper
• Evolution, energy landscapes and the paradoxes of protein folding.

  2015cites this paper
• Non-native structure appears in microseconds during the folding of E. coli RNase H.

  2015cites this paper
• Engineering and characterization of a binder to inhibit in vivo α-synuclein aggregation

  2015cites this paper
• Protein Misfolding Diseases: In Perspective of Gain and Loss of Function

  2015cites this paper
• Prediction of the optimal set of contacts to fold the smallest knotted protein

  2015cites this paper
• Transient Non-Native Helix Formation during the Folding of β-Lactoglobulin

  2014cites this paper
• Multistage unfolding of an SH3 domain: an initial urea-filled dry molten globule precedes a wet molten globule with non-native structure.

  2014cites this paper
• Energetic Frustrations in Protein Folding at Residue Resolution: A Homologous Simulation Study of Im9 Proteins

  2014cites this paper
• Effect of non-native helix destabilization on the folding of equine β-lactoglobulin.

  2014cites this paper
• Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: What have we learned to date?

  2014cites this paper
• The role of surface amino acid residues in protein folding and stability

  2014influential citation
• Cytosolic Selection Systems To Study Protein Stability

  2014cites this paper
• Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

  2014cites this paper
• Visualizing side chains of invisible protein conformers by solution NMR.

  2014cites this paper
• Measurement of histidine pKa values and tautomer populations in invisible protein states

  2014cites this paper
• Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule

  2014cites this paper
• Misfolding of luciferase at the single-molecule level.

  2014cites this paper
• Detailed characterization of the earliest events in protein folding

  2014cites this paper
• Assessing the effect of dynamics on the closed-loop protein-folding hypothesis

  2014cites this paper
• Correction: Energetic Frustrations in Protein Folding at Residue Resolution: A Homologous Simulation Study of Im9 Proteins

  2014cites this paper
• The role of high-dimensional diffusive search, stabilization, and frustration in protein folding.

  2014cites this paper
• Identification of fibril-like tertiary contacts in soluble monomeric α-synuclein.

  2013cites this paper
• Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

  2013cites this paper
• Conformational dynamics is more important than helical propensity for the folding of the all α‐helical protein Im7

  2013cites this paper
• MORPHOGENESIS OF PROTEINS: CLASSIC VIEWS AND CHALLENGES AHEAD

  2013influential citation
• In vivo detection and quantification of chemicals that enhance protein stability.

  2013influential citation
• Principles of Protein Folding

  2013cites this paper
• Probing slowly exchanging protein systems via 13Cα-CEST: monitoring folding of the Im7 protein

  2013cites this paper
• Protein destabilisation in ionic liquids: the role of preferential interactions in denaturation.

  2013cites this paper
• Take home lessons from studies of related proteins

  2013cites this paper
• The how's and why's of protein folding intermediates.

  2013cites this paper
• Frustration in biomolecules

  2013cites this paper
• Protein structural dynamics and thermodynamics from advanced simulation techniques

  2013cites this paper
• How well does a funneled energy landscape capture the folding mechanism of spectrin domains?

  2013cites this paper
• Photo-CIDNP NMR spectroscopy of amino acids and proteins.

  2013cites this paper
• Effects of Macromolecular Crowding on Protein Folding : - in-vitro equilibrium and kinetic studies on selected model systems

  2013cites this paper
• Mechanisms of outer membrane protein folding: effects of the lipid environment and periplasmic chaperones

  2013cites this paper
• Overview of Protein Folding Mechanisms: Experimental and Theoretical Approaches to Probing Energy Landscapes

  2012cites this paper
• Cross-validation of the structure of a transiently formed and low populated FF domain folding intermediate determined by relaxation dispersion NMR and CS-Rosetta.

  2012influential citation
• Single molecule investigations of chaperone assisted protein folding

  2012cites this paper
• Nonnative interactions regulate folding and switching of myristoylated protein

  2012cites this paper
• 3.4 Intermediates in Protein Folding

  2012cites this paper
• Determining the native and nonnative effects of myristoylation on the folding and switching of hisactophilin

  2012cites this paper
• 3.1 Combining Simulation and Experiment to Map Protein Folding

  2012cites this paper
• The H2A-H2B dimeric kinetic intermediate is stabilized by widespread hydrophobic burial with few fully native interactions.

  2012cites this paper
• De novo prediction of protein folding pathways and structure using the principle of sequential stabilization

  2012cites this paper