ADAR RNA editing in human disease; more to it than meets the I

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Human Genetics

• Publication date

  2017-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00439-017-1837-0PMID 28913566
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon*

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• Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis

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• Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

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• ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.

  2016cited by this paper
• ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm

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• e23D: database and visualization of A-to-I RNA editing sites mapped to 3D protein structures

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• ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity

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• Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.

  2016cited by this paper
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• Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

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• Profiling RNA editing in human tissues: towards the inosinome Atlas

  2015cited by this paper
• Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.

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• Aicardi–Goutières syndrome and the type I interferonopathies

  2015cited by this paper
• The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

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• RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

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• Genetics of autoimmune diseases: insights from population genetics

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• Genomic Analysis of ADAR1 Binding and its Involvement in Multiple RNA Processing Pathways

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• Hypo Adenosine-to-Inosine miR-455-5p Editing Promotes Melanoma Growth and Metastasis

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• Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

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• Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.

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• Abstract 5189: RNA editing in rhoq promotes invasion potential in colorectal cancer

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  2014cited by this paper
• The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

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• Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.

  2014cited by this paper
• A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

  2014cited by this paper
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• A type I interferon signature identifies bilateral striatal necrosis due to mutations in ADAR1

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• RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

  2013cited by this paper
• Deletion of the RNA‐editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice

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• MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.

  2013cited by this paper
• ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

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• Deep sequencing the circadian and diurnal transcriptome of Drosophila brain

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• Canonical A-to-I and C-to-U RNA Editing Is Enriched at 3′UTRs and microRNA Target Sites in Multiple Mouse Tissues

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• Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

  2012cited by this paper
• Role of ADARs in mouse development.

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• Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

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• Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.

  2012cited by this paper
• Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

  2012cited by this paper
• RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence

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• Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells.

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• ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis

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• AMPA Receptor Regulation at the mRNA and Protein Level in Rat Primary Cortical Cultures

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• Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.

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• Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

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• Predicting sites of ADAR editing in double-stranded RNA

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• Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

  2010cited by this paper
• The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.

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• Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities.

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• Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.

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