Targeted activation of β-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Development

• Publication date

  2005-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.01583PMID 15590737
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular characterization of the tumor microenvironment in breast cancer.

  2004cited by this paper
• p63 is the molecular switch for initiation of an epithelial stratification program.

  2004cited by this paper
• The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

  2004cited by this paper
• Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

  2004cited by this paper
• p63: Molecular complexity in development and cancer.

  2004cited by this paper
• Convergence of Wnt, ß-Catenin, and Cadherin Pathways

  2004cited by this paper
• p53 protein variants: structural and functional similarities with p63 and p73 isoforms

  2004cited by this paper
• Convergence of Wnt, beta-catenin, and cadherin pathways.

  2004cited by this paper
• Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.

  2003cited by this paper
• Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

  2003cited by this paper
• ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development

  2003cited by this paper
• Repeated observation of breast tumor subtypes in independent gene expression data sets

  2003cited by this paper
• Mammary epithelial stem cells: transplantation and self‐renewal analysis

  2003cited by this paper
• Stem cells in the skin: waste not, Wnt not.

  2003cited by this paper
• A β-catenin survival signal is required for normal lobular development in the mammary gland

  2003cited by this paper
• A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

  2003cited by this paper
• DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development.

  2003cited by this paper
• In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.

  2003cited by this paper
• Stem cells and breast cancer: A field in transit

  2003cited by this paper
• Dissecting the roles of β-catenin and cyclin D1 during mammary development and neoplasia

  2003cited by this paper
• Caught up in a Wnt storm: Wnt signaling in cancer.

  2003cited by this paper
• Live and let die in the intestinal epithelium.

  2003cited by this paper
• Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

  2002cited by this paper
• TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression.

  2002cited by this paper
• The importance of being a myoepithelial cell

  2002cited by this paper
• TAp63γ (p51A) and dNp63α (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression

  2002cited by this paper
• Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept

  2002cited by this paper
• Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

  2002cited by this paper
• Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.

  2002cited by this paper
• The p53 and Mdm2 families in cancer.

  2002cited by this paper
• Activation of different Wnt/β-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors

  2002cited by this paper
• EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties

  2002cited by this paper
• Stromal Effects on Mammary Gland Development and Breast Cancer

  2002influential reference
• Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

  2001influential reference
• Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

  2001cited by this paper
• β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland

  2001cited by this paper
• Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

  2001cited by this paper
• Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.

  2001cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling.

  2000cited by this paper
• Molecular portraits of human breast tumours

  2000cited by this paper
• The mammary myoepithelial cell - Cinderella or ugly sister?

  2000cited by this paper
• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

  1999cited by this paper
• p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

  1999cited by this paper
• The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.

  1999cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• Differentiation of Separated Mouse Mammary Luminal Epithelial and Myoepithelial Cells Cultured on EHS Matrix Analyzed by Indirect Immunofluorescence of Cytoskeletal Antigens

  1999cited by this paper
• Human mammary luminal epithelial cells contain progenitors to myoepithelial cells.

  1999cited by this paper
• p63 is a p53 homologue required for limb and epidermal morphogenesis

  1999cited by this paper
• De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.

  1998cited by this paper
• De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

  1998cited by this paper
• Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

  1997cited by this paper
• The human myoepithelial cell is a natural tumor suppressor.

  1997cited by this paper
• Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene

  1996cited by this paper
• Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice.

  1995cited by this paper
• Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

  1995cited by this paper
• Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

  1994cited by this paper
• Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development.

  1994cited by this paper
• Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland.

  1994cited by this paper
• Localization and quantification of Wnt-2 gene expression in mouse mammary development.

  1993cited by this paper
• Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland

  1992cited by this paper
• Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.

  1988cited by this paper
• A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland.

  1988cited by this paper

• Mechanisms of Regulation of Cell Fate in Breast Development and Cancer.

  2025cites this paper
• The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms

  2024cites this paper
• Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

  2024cites this paper
• C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle

  2024cites this paper
• WNT1/ROR2 pathway enhances the Triple‐Negative breast cancer invasion, migration, and Epithelial‐Mesenchymal transition

  2024cites this paper
• Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion

  2024cites this paper
• AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer

  2023cites this paper
• p63: a crucial player in epithelial stemness regulation

  2023cites this paper
• CgWnt-1 regulates haemocyte proliferation during immune response of oyster Crassostrea gigas.

  2023cites this paper
• Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.

  2023cites this paper
• Cancer invasion and metastasis: Insights from murine pubertal mammary gland morphogenesis.

  2023cites this paper
• Diverse roles for axon guidance pathways in adult tissue architecture and function.

  2022cites this paper
• Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.

  2022cites this paper
• ERK1/2-RSK regulation of oestrogen homeostasis

  2022cites this paper
• MORC2/β-catenin signaling axis promotes proliferation and migration of breast cancer cells

  2022cites this paper
• Alveolar progenitor differentiation and lactation depends on paracrine inhibition of notch via ROBO1/CTNNB1/JAG1

  2021cites this paper
• ATF3-Induced Mammary Tumors Exhibit Molecular Features of Human Basal-Like Breast Cancer

  2021cites this paper
• Wnt signaling and mammary stem cells.

  2021cites this paper
• In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation

  2021cites this paper
• Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.

  2021cites this paper
• Tyrosine kinase inhibitors and their unique therapeutic potentialities to combat cancer.

  2020cites this paper
• Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation

  2020cites this paper
• Cancer cell-intrinsic function of CD177 in attenuating β-Catenin signaling

  2020cites this paper
• A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing

  2020cites this paper
• Compromised nuclear envelope integrity drives tumor cell invasion

  2020cites this paper
• Hdc-expressing myeloid-derived suppressor cells promote basal-like transition and metastasis of breast cancer.

  2020cites this paper
• Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer

  2019cites this paper
• Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins

  2019cites this paper
• Development of a drug repressible β-catenin mutant mouse to examine effect of activated β-catenin signaling on long-term maintenance of mammary tumor growth

  2019cites this paper
• Gestational and Lactational Exposure to an Environmentally-relevant Mixture of Brominated Flame Retardants Down-regulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty.

  2019cites this paper
• RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT

  2019cites this paper
• A new analytical pipeline for the study of the onset of mammary gland oncogenesis based on mammary organoid transplantation and organ clearing

  2019cites this paper
• The multifaceted roles of CD177 in mammary tissue development and breast cancer

  2018cites this paper
• Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling

  2018cites this paper
• Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors

  2018cites this paper
• The Wnt Signaling Landscape of Mammary Stem Cells and Breast Tumors.

  2018cites this paper
• Prostate Organogenesis.

  2018cites this paper
• Cpeb2 in mammary gland homeòstasis and breast cancer

  2018cites this paper
• LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers

  2018cites this paper
• Cross-Species Meta-Analysis of Transcriptomic Data in Combination With Supervised Machine Learning Models Identifies the Common Gene Signature of Lactation Process

  2018cites this paper
• Integrin-Rac signalling for mammary epithelial stem cell self-renewal

  2018cites this paper
• MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

  2017cites this paper
• Expression and its Interaction with E-Cadherin in the Mammary Glands of Lactating Rats

  2017cites this paper
• Morphoregulatory pathways in prostate ductal development

  2017cites this paper
• Clinical value of R-spondins in triple-negative and metaplastic breast cancers

  2017cites this paper
• p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors

  2017cites this paper
• From the Cover: Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Decreased p-&bgr;-Cateninser675 Expression and Its Interaction With E-Cadherin in the Mammary Glands of Lactating Rats

  2017cites this paper
• Mouse Models of Breast Cancer: Deceptions that Reveal the Truth

  2017cites this paper
• Fundamental Pathways in Breast Cancer 4: Signaling to Chromatin in Breast Development

  2017cites this paper
• Unraveling the expression and regulation of intercellular junctions in normal and Brominated Flame Retardants (BFRs) treated murine mammary glands

  2017cites this paper
• Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

  2017cites this paper
• The role of Runx1 in genetic models of breast cancer

  2017cites this paper
• β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells

  2017cites this paper
• Molecular mechanisms of asymmetric divisions in mammary stem cells

  2016cites this paper
• The role of β1-integrin in mammary stem and progenitor fate

  2016cites this paper
• p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

  2016cites this paper
• Cell lineage determinants as regulators of breast cancer metastasis

  2016cites this paper
• Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells

  2016cites this paper
• Tumors of the Mammary Gland

  2016cites this paper
• Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy

  2016cites this paper
• Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS.

  2015cites this paper
• Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration.

  2015cites this paper
• Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells

  2015cites this paper
• Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice

  2015cites this paper
• Role of ARF6 in breast cancer cell invasion

  2014cites this paper
• p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis

  2014cites this paper
• Noncanonical Wnt signaling in breast cancer initiation and progression

  2014cites this paper
• ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling

  2014cites this paper
• Expression profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays

  2014cites this paper
• SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

  2014cites this paper
• Secreted frizzled related proteins: Implications in cancers.

  2014cites this paper
• Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

  2013cites this paper
• Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis

  2013influential citation
• Transcriptional regulators of the ΔNp63: Their role in limbal epithelial cell proliferation

  2013cites this paper
• Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminal

  2013cites this paper
• Cellular and molecular effects of early pregnancy on mammary epithelial cell subpopulations in mice and their potential relevance for breast cancer protection

  2013cites this paper
• Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

  2013cites this paper
• Signaling events mediated by α3β1 integrin are essential for mammary tumorigenesis

  2013cites this paper
• Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice.

  2013cites this paper
• Role of the WNT-regulated transcription cofactor LBH in normal and neoplastic mammary stem cell control

  2013cites this paper
• Therapeutic targets in triple negative breast cancer

  2013cites this paper
• Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.

  2013cites this paper
• Etude du rôle des intégrines liant la laminine dans le développement et la tumorigenèse mammaires

  2013cites this paper
• Effect of exogenous somatotropin and staged ovariectomy on mRNA expression of select ECM-related proteins in mammary tissue of prepubertal Holstein calves

  2013cites this paper
• Developmental changes in the properties of mouse mammary stem cells

  2013cites this paper
• The roles of the APC proteins in homeostasis and tumourigenesis

  2013cites this paper
• Active Roles of Tumor Stroma in Breast Cancer Metastasis

  2012cites this paper
• The role of WNT10B in physiology and disease

  2012cites this paper
• Fas-associated Factor 1 Is a Scaffold Protein That Promotes β-Transducin Repeat-containing Protein (β-TrCP)-mediated β-Catenin Ubiquitination and Degradation*

  2012cites this paper
• Wnt signalling in murine postnatal mammary gland development

  2012cites this paper
• Etude des cellules souches et progénitrices mammaires et de leur contribution à la tumorigenèse : rôle des facteurs de transcription Myc et p53

  2012influential citation
• Calpain Induces N-terminal Truncation of β-Catenin in Normal Murine Liver Development

  2012cites this paper
• Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3.

  2012cites this paper
• Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.

  2012cites this paper
• TARGETING THE PERPETRATOR: CANCER STEM CELL THERAPEUTICS

  2012cites this paper
• Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland.

  2012cites this paper
• The role of gamma-synuclein in mammary gland tumourigenesis

  2012cites this paper
• The Proto‐Oncogene Myc Is Essential for Mammary Stem Cell Function

  2012cites this paper
• Strategies for the discovery and development of therapies for metastatic breast cancer

  2012cites this paper
• Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.

  2012cites this paper