CD8+ T Cell Activation Is Governed by TCR-Peptide/MHC Affinity, Not Dissociation Rate1

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Immunology

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.179.5.2952PMID 17709510
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Potent T cell agonism mediated by a very rapid TCR/pMHC interaction

  2007cited by this paper
• Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.

  2006cited by this paper
• Peripheral “CD8 Tuning” Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo1

  2005cited by this paper
• Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties.

  2004cited by this paper
• Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation.

  2003cited by this paper
• Caveats in the design of MHC class I tetramer/antigen-specific T lymphocytes dissociation assays.

  2003cited by this paper
• A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.

  2003cited by this paper
• Molecular interactions mediating T cell antigen recognition.

  2003cited by this paper
• TCR Binding Kinetics Measured with MHC Class I Tetramers Reveal a Positive Selecting Peptide with Relatively High Affinity for TCR 1

  2003cited by this paper
• Weak agonist self‐peptides promote selection and tuning of virus‐specific T cells

  2003cited by this paper
• Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Affinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement 1

  2003cited by this paper
• Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.

  2003cited by this paper
• High Affinity Xenoreactive TCR:MHC Interaction Recruits CD8 in Absence of Binding to MHC1

  2003cited by this paper
• Peptidic Termini Play a Significant Role in TCR Recognition1

  2002cited by this paper
• The specificity of TCR/pMHC interaction.

  2002cited by this paper
• Structural and thermodynamic correlates of T cell signaling.

  2002cited by this paper
• Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

  2001cited by this paper
• The TCR triggering puzzle.

  2001cited by this paper
• Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation

  2001cited by this paper
• The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model.

  2001cited by this paper
• Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells1

  2000cited by this paper
• Characterizing the functionality of recombinant T-cell receptors in vitro: a pMHC tetramer based approach.

  2000cited by this paper
• Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

  2000cited by this paper
• Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex.

  2000influential reference
• Identification of a cross‐reactive self ligand in virus‐mediated autoimmunity

  1999cited by this paper
• Structural Evidence of  T Cell Xeno-reactivity in the Absence of Molecular Mimicry

  1999cited by this paper
• Absence of co‐stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo

  1999cited by this paper
• Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

  1999cited by this paper
• Binding energetics of T-cell receptors: correlation with immunological consequences.

  1999cited by this paper
• From TCR Engagement to Minireview T Cell Activation: A Kinetic View of T Cell Behavior

  1999cited by this paper
• Ligand recognition by alpha beta T cell receptors.

  1998cited by this paper
• LIGAND RECOGNITION BY T CELL RECEPTORS

  1998cited by this paper
• High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling.

  1998cited by this paper
• Correlates with Thymocyte Selection Flux 2+ Degree of TCR Internalization and Ca

  1998cited by this paper
• CLAMP: a biosensor kinetic data analysis program.

  1998cited by this paper
• T cell positive selection by a high density, low affinity ligand.

  1998cited by this paper
• Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

  1997cited by this paper
• Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models.

  1997cited by this paper
• Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.

  1997cited by this paper
• Duration of TCR stimulation determines costimulatory requirement of T cells.

  1996cited by this paper
• A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists.

  1996cited by this paper
• Kinetic discrimination in T-cell activation.

  1996cited by this paper
• T-cell-receptor affinity and thymocyte positive selection

  1996cited by this paper
• An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

  1996cited by this paper
• Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2.

  1996cited by this paper
• Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity.

  1996cited by this paper
• Mature T cell reactivity altered by peptide agonist that induces positive selection

  1996influential reference
• Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity.

  1995cited by this paper
• CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

  1995cited by this paper
• Serial triggering of many T-cell receptors by a few peptide–MHC complexes

  1995cited by this paper
• The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

  1995cited by this paper
• Kinetic proofreading in T-cell receptor signal transduction.

  1995cited by this paper
• Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

  1994cited by this paper
• Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes.

  1994cited by this paper
• Evidence for a differential avidity model of T cell selection in the thymus.

  1994cited by this paper
• Positive and negative thymocyte selection induced by different concentrations of a single peptide.

  1994cited by this paper
• Regulation of src family tyrosine kinases in lymphocytes.

  1993cited by this paper
• Accessory molecules involved in antigen-mediated cytolysis and lymphokine production by cytotoxic T lymphocyte subsets. I. Identification of functions for the T cell surface molecules Ly-6C and Thy-1.

  1993cited by this paper
• The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation.

  1992cited by this paper
• Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

  1990influential reference
• Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

  1989cited by this paper
• Characterization of anti-CD8-resistant cytolytic T lymphocytes induced by multivalent cross-linking of CD8 on precursor cells.

  1989cited by this paper

• Dynamical network analysis reveals long-range residue couplings at the pMHC interface underlying enhanced immunogenicity

  2026cites this paper
• THLANet: A deep learning framework for predicting TCR-pHLA binding in immunotherapy applications

  2025cites this paper
• A comparative mathematical modeling study of phenotypic approaches to T cell activation

  2025cites this paper
• Deep-Red and Ultrafast Photocatalytic Proximity Labeling Empowered In Situ Dissection of Tumor-Immune Interactions in Primary Tissues.

  2025cites this paper
• Immunologic specificity in glioblastoma: Antigen discovery and translational implications

  2025cites this paper
• Use of Affimer technology for inhibition of α2-antiplasmin and enhancement of fibrinolysis

  2024cites this paper
• Should Artificial Intelligence Play a Durable Role in Biomedical Research and Practice?

  2024cites this paper
• Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms.

  2024cites this paper
• Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen

  2024cites this paper
• Unveiling cross-reactivity: implications for immune response modulation in cancer

  2024cites this paper
• Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab’-DNA ligand

  2024cites this paper
• Epitope-anchored contrastive transfer learning for paired CD8+ cell receptor-antigen recognition

  2024cites this paper
• Differential Roles of Kinetic On- and Off-Rates in T-Cell Receptor Signal Integration Revealed with a Modified Fab’-DNA Ligand

  2024cites this paper
• T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome

  2023cites this paper
• Individual Epitope-Specific CD8+ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

  2023cites this paper
• Global koff‐rates of polyclonal T‐cell populations merge subclonal avidities and predict functionality

  2022cites this paper
• Single-intraosseous simvastatin injection suppresses cancers via activating CD8+ T cells.

  2022cites this paper
• Antibody variable region engineering for improving cancer immunotherapy

  2022cites this paper
• Influenza B: Prospects for the Development of Cross-Protective Vaccines

  2022cites this paper
• Tumor immunotherapy: Mechanisms and clinical applications

  2022cites this paper
• The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

  2022cites this paper
• 1% of Bill Goddard

  2021cites this paper
• Mechanobiology of T Cell Activation: To Catch a Bond.

  2021cites this paper
• An Agent-Based Model of T Helper Cell Fate Decisions in the Thymus

  2021cites this paper
• HLA class I and II associations with common enteric pathogens in the first year of life

  2021cites this paper
• CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs

  2021cites this paper
• Structural dissimilarity from self drives neoepitope escape from immune tolerance

  2020cites this paper
• Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening.

  2020cites this paper
• Relationship of 2D Affinity to T Cell Functional Outcomes

  2020cites this paper
• Modelling the interplay between the CD4\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{+}$$\end{document}+/CD8\docum

  2020cites this paper
• The discriminatory power of the T cell receptor

  2020cites this paper
• Personalized cancer vaccination in head and neck cancer

  2020cites this paper
• T‐cell receptor affinity in the age of cancer immunotherapy

  2020cites this paper
• Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy

  2019cites this paper
• Relaxation times of ligand-receptor complex formation control T cell activation

  2019cites this paper
• Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

  2019cites this paper
• Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space

  2019cites this paper
• Nucleoprotein vaccine induces cross-protective cytotoxic T lymphocytes against both lineages of influenza B virus

  2019cites this paper
• Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition

  2018cites this paper
• COMPARISON OF A DUAL STRATEGY FOR T-CELL ACTIVATION UNDER INHIBITION OF THE CD4 RECEPTOR

  2018cites this paper
• The function and dysfunction of memory CD8+ T cells in tumor immunity

  2018cites this paper
• 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes

  2018cites this paper
• Immunogenicity landscape of cytotoxic T lymphocyte epitopes in sequence space

  2018cites this paper
• The landscape of T cell epitope immunogenicity in sequence space

  2018influential citation
• TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency.

  2017cites this paper
• Targeting neoantigens to augment antitumour immunity

  2017cites this paper
• Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

  2017cites this paper
• Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor

  2017cites this paper
• Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells

  2017cites this paper
• The Dawn of Quantum Immunology -

  2017cites this paper
• The impact of altered T cell receptor---peptide-major histocompatibility complex interactions on antigen recognition and T cell function

  2016influential citation
• TCR Signaling: Proximal Signaling

  2016cites this paper
• Récepteurs d'antigènes chimères (car) utilisés dans un traitement et méthodes de fabrication associées

  2015cites this paper
• Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens

  2015cites this paper
• Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma

  2015cites this paper
• Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence

  2015cites this paper
• Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells.

  2015cites this paper
• Toll-Like Receptor 2 Targeted Rectification of Impaired CD8+ T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection

  2015cites this paper
• To affinity and beyond: Harnessing the T Cell receptor for cancer immunotherapy

  2014cites this paper
• T Cell Avidity and Tumor Immunity: Problems and Solutions

  2014cites this paper
• Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model.

  2014cites this paper
• TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8+ T Cells in Mamu-A*01 + Rhesus Monkeys

  2014cites this paper
• Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

  2014cites this paper
• 2D TCR–pMHC–CD8 kinetics determines T‐cell responses in a self‐antigen‐specific TCR system

  2014cites this paper
• Inflammation and TCR Signal Strength Determine the Breadth of the T Cell Response in a Bim-Dependent Manner

  2014cites this paper
• Phenotypic models of T cell activation

  2014cites this paper
• Engineering improved T cell receptors using an alanine-scan guided T cell display selection system.

  2013cites this paper
• Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy

  2013cites this paper
• The Problem of Antigen Affinity Discrimination in B-Cell Immunology

  2013cites this paper
• Structure-Based, Rational Design of T Cell Receptors

  2013cites this paper
• T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

  2013cites this paper
• Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

  2013cites this paper
• Quantifying Biomass Changes of Single CD8+ T Cells during Antigen Specific Cytotoxicity

  2013cites this paper
• Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies

  2013cites this paper
• Dissecting T‐cell activation with high‐resolution live‐cell microscopy

  2012cites this paper
• Different affinity windows for virus and cancer‐specific T‐cell receptors: Implications for therapeutic strategies

  2012cites this paper
• Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness*

  2012cites this paper
• The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy

  2012influential citation
• Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

  2012cites this paper
• Structural and biophysical determinants of αβ T‐cell antigen recognition

  2012cites this paper
• ELICITATION AND ENHANCEMENT OF T AND B CELL RESPONSES

  2012cites this paper
• Unexpected T‐cell recognition of an altered peptide ligand is driven by reversed thermodynamics

  2012cites this paper
• The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction

  2012cites this paper
• A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88.

  2012cites this paper
• Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection

  2012cites this paper
• T cell triggering: insights from 2D kinetics analysis of molecular interactions

  2012cites this paper
• Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex

  2012cites this paper
• Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurements.

  2012cites this paper
• Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.

  2012cites this paper
• A TCR Affinity Threshold Regulates Memory CD4 T Cell Differentiation following Vaccination

  2012cites this paper
• Advances in Direct T‐Cell Alloreactivity: Function, Avidity, Biophysics and Structure

  2012cites this paper
• Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

  2011cites this paper
• Ex-Vivo Recognition of Late-Lytic CD8 Epitopes Specific for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by HIV/KSHV-Coinfected Individuals

  2011cites this paper
• A Review of Mathematical Models for T Cell Receptor Triggering and Antigen Discrimination

  2011cites this paper
• How T cell receptors interact with peptide‐MHCs: A multiple steered molecular dynamics study

  2011cites this paper
• ImMucin: a novel therapeutic vaccine with promiscuous MHC binding for the treatment of MUC1-expressing tumors.

  2011cites this paper
• Stem cell-based anti-HIV gene therapy.

  2011cites this paper
• Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses

  2011cites this paper
• Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

  2011cites this paper
• Strength of TCR–Peptide/MHC Interactions and In Vivo T Cell Responses

  2011cites this paper