Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Molecular Biology

• Publication date

  2001-10-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1006/JMBI.2001.4970PMID 11580253
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

  2001cited by this paper
• In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

  2001cited by this paper
• Temperature-induced conformational changes in amyloid beta(1-40) peptide investigated by simultaneous FT-IR microspectroscopy with thermal system.

  2001cited by this paper
• The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

  2001cited by this paper
• Prediction of Amyloid Fibril-forming Proteins*

  2001cited by this paper
• The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

  2001cited by this paper
• Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry.

  2000cited by this paper
• High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

  2000cited by this paper
• A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

  2000cited by this paper
• Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis.

  2000cited by this paper
• Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

  2000cited by this paper
• Construction of Peptides That Undergo Structural Transition from α-Helix to β-Sheet and Amyloid Fibril Formation by the Introduction of N-Terminal Hydrophobic Amino Acids

  2000cited by this paper
• Solid-state NMR determination of the secondary structure of Samia cynthia ricini silk

  2000cited by this paper
• Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy

  2000cited by this paper
• Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.

  2000cited by this paper
• Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

  2000cited by this paper
• Alzheimer's amyloid fibrils: structure and assembly.

  2000cited by this paper
• An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

  2000cited by this paper
• Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions.

  2000cited by this paper
• Amyloid fibrillogenesis: themes and variations.

  2000cited by this paper
• An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments

  2000cited by this paper
• A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils

  2000cited by this paper
• Neurotoxic and fibrillogenic properties of amino-terminally modified amyloid β-peptides

  2000cited by this paper
• Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

  2000cited by this paper
• Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

  2000cited by this paper
• Solid-state NMR as a probe of amyloid fibril structure.

  2000cited by this paper
• A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

  2000cited by this paper
• Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.

  2000cited by this paper
• The Alzheimer's peptide a beta adopts a collapsed coil structure in water.

  2000cited by this paper
• Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.

  2000cited by this paper
• Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.

  1999cited by this paper
• Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain*

  1999cited by this paper
• Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

  1999cited by this paper
• Translating cell biology into therapeutic advances in Alzheimer's disease

  1999cited by this paper
• Amyloid, prions, and other protein aggregates

  1999cited by this paper
• Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

  1999cited by this paper
• Solution structure of Syrian hamster prion protein rPrP(90-231).

  1999cited by this paper
• Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

  1999cited by this paper
• Monitoring protein assembly using quasielastic light scattering spectroscopy.

  1999cited by this paper
• Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

  1999cited by this paper
• Alzheimer’s and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches

  1999cited by this paper
• Alpha‐synuclein in Lewy Body Disease and Alzheimer's Disease

  1999cited by this paper
• Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease.

  1999cited by this paper
• Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

  1999cited by this paper
• Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation*

  1999cited by this paper
• Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

  1998cited by this paper
• Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes*

  1998cited by this paper
• Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

  1998cited by this paper
• Structural and kinetic features of amyloid beta-protein fibrillogenesis.

  1998cited by this paper
• Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

  1998cited by this paper
• Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

  1998cited by this paper
• Observation of metastable Aβ amyloid protofibrils by atomic force microscopy

  1997cited by this paper
• Kinetics and mechanism of amyloid formation by the prion protein H1 peptide as determined by time-dependent ESR.

  1997cited by this paper
• Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.

  1997cited by this paper
• Zinc-induced Alzheimer’s Aβ1–40 Aggregation Is Mediated by Conformational Factors*

  1997cited by this paper
• Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

  1997cited by this paper
• Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

  1997cited by this paper
• Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

  1997cited by this paper
• Heterogeneity of water‐soluble amyloid β‐peptide in Alzheimer's disease and Down's syndrome brains

  1997cited by this paper
• Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.

  1997cited by this paper
• Observation of metastable Abeta amyloid protofibrils by atomic force microscopy.

  1997cited by this paper
• Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

  1997cited by this paper
• The prion folding problem.

  1997cited by this paper
• Engineering peptides and proteins that undergo alpha-to-beta transitions.

  1997cited by this paper
• Engineering peptides and proteins that undergo α-to-β transitions

  1997cited by this paper
• Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

  1996cited by this paper
• Circular Dichroism and the Conformational Analysis of Biomolecules

  1996cited by this paper
• On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

  1996cited by this paper
• NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded.

  1996cited by this paper
• Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence.

  1996cited by this paper
• Stopped-Flow Circular Dichroism

  1996cited by this paper
• Determination of Protein Secondary Structure

  1996cited by this paper
• Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence†

  1996cited by this paper
• Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.

  1995cited by this paper
• Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

  1995cited by this paper
• The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation *

  1995cited by this paper
• Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

  1995cited by this paper
• 1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence.

  1995cited by this paper
• Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress

  1995cited by this paper
• Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

  1994cited by this paper
• Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues.

  1994cited by this paper
• Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

  1994cited by this paper
• Racemization: its biological significance on neuropathogenesis of Alzheimer's disease.

  1994cited by this paper
• Rapid induction of Alzheimer A beta amyloid formation by zinc.

  1994cited by this paper
• Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

  1994cited by this paper
• Understanding how proteins fold: the lysozyme story so far.

  1994cited by this paper
• Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

  1993cited by this paper
• Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease.

  1993cited by this paper
• Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

  1993cited by this paper
• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  1993cited by this paper
• Analysis of the circular dichroism spectrum of proteins using the convex constraint algorithm: a practical guide.

  1992cited by this paper
• Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra.

  1992cited by this paper
• Beta-amyloid precursor protein cleavage by a membrane-bound protease.

  1992cited by this paper
• Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.

  1992cited by this paper
• Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

  1992cited by this paper
• The molecular pathology of Alzheimer's disease.

  1991cited by this paper
• Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

  1991cited by this paper
• pH-dependent structural transitions of Alzheimer amyloid peptides.

  1991cited by this paper
• Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

  1991cited by this paper
• Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

  1990cited by this paper

• Membrane-Mimetic Micelles Drive Structural Switching in Uperin 3.5.

  2026cites this paper
• Solution NMR reveals micelle-stabilized α-helical segments flanking the RIPK1 RHIM amyloid core.

  2026cites this paper
• Protein disulfide isomerase dissolves and detoxifies oligomeric assemblies of amyloid beta peptide.

  2026cites this paper
• Impact of counterion and salt form on the properties of long-acting injectable peptide hydrogels for drug delivery

  2025cites this paper
• Investigating the inhibitory effect of gold nanoparticles with different diameters on the aggregation behavior of Aβ40 and Aβ42 peptides involved in Alzheimer's disease using molecular dynamics simulations

  2025cites this paper
• Highly sensitive detection of different aggregation stages of Aβ1-42 -amyloid peptide in urine-like samples by auto-fluorescence.

  2025cites this paper
• Disclosing Pathogenic Variant Effects on the Structural Dynamics of the VAPB MSP Domain Causing Familial ALS

  2025cites this paper
• The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player

  2025cites this paper
• Effect of a Low Electrostatic Environment on the Helical Structures of Peptides and Proteins Using Flexible Water Models: An In Silico Study

  2025cites this paper
• Impact of Amidation on Aβ25-35 Aggregation.

  2025cites this paper
• Effect of amyloid-beta 1-40 and 1-42 peptides on the lateral diffusion and signaling of receptor for advanced glycation endproducts (RAGE).

  2025cites this paper
• Fibrillation of Human Serum Albumin Differentially Affected by Asp-, Arg-, and Tyr-Capped Gold Nanoparticles.

  2024cites this paper
• Origin of Secondary Structure Transitions and Peptide Self-Assembly Propensity in Trifluoroethanol-Water Mixtures.

  2024cites this paper
• Viral Infections, Are They a Trigger and Risk Factor of Alzheimer’s Disease?

  2024cites this paper
• Exploring Structural Insights of Aβ42 and α-Synuclein Monomers and Heterodimer: A Comparative Study Using Implicit and Explicit Solvent Simulations

  2024cites this paper
• Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer’s disease

  2024cites this paper
• A Practical Guide to All-Atom and Coarse-Grained Molecular Dynamics Simulations Using Amber and Gromacs: A Case Study of Disulfide-Bond Impact on the Intrinsically Disordered Amyloid Beta

  2024cites this paper
• Understanding the structural dynamics of human islet amyloid polypeptide: Advancements in and applications of ion-mobility mass spectrometry.

  2024cites this paper
• An expeditious and facile method of amyloid beta (1–42) purification

  2024cites this paper
• Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective

  2024cites this paper
• Survey of the Aβ-peptide structural diversity: molecular dynamics approaches

  2024cites this paper
• Pyroglutamylation modulates electronic properties and the conformational ensemble of the amyloid β‐peptide

  2024cites this paper
• Revealing the regulation of water dipole potential to aggregation of amyloid‐β 42 at chiral interface by surface‐enhanced infrared absorption spectroscopy

  2024cites this paper
• Role of Human Serum Albumin in the Prevention and Treatment of Alzheimer’s Disease

  2024cites this paper
• Structure Comparison of Beta Amyloid Peptide Aβ 1-42 Isoforms. Molecular Dynamics Modeling

  2024cites this paper
• Helix-to-sheet transition of the Aβ42 peptide revealed using an enhanced sampling strategy and Markov state model

  2023cites this paper
• N-terminal truncation of peptide effects on human serum albumin and beta amyloid peptide interaction

  2023cites this paper
• Helical Intermediate Formation and Its Role in Amyloid of an Amphibian Antimicrobial Peptide†

  2023cites this paper
• Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments

  2023cites this paper
• The role of human serum albumin in prevention and treatment of Alzheimer’s disease

  2023cites this paper
• The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) as a new molecule able to inhibit Amyloid β aggregation and neurotoxicity.

  2023cites this paper
• What can AlphaFold do for antimicrobial amyloids?

  2023cites this paper
• Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils

  2023cites this paper
• Peptide Self-Assembly into Amyloid Fibrils at Hard and Soft Interfaces - From Corona Formation to Membrane Activity.

  2023cites this paper
• Metastable alpha‐rich and beta‐rich conformations of small Aβ42 peptide oligomers

  2023cites this paper
• Flanking regions, amyloid cores, and polymorphism: the potential interplay underlying structural diversity

  2023cites this paper
• Conformational Features of Beta-Amyloid Peptide 25–35

  2023cites this paper
• Conformational particularities of beta-amyloid peptide 25-35

  2023cites this paper
• Anatomy and formation mechanisms of early amyloid-β oligomers with lateral branching: graph network analysis on large-scale simulations

  2022cites this paper
• Intrinsically disordered proteins/regions and insight into their biomolecular interactions.

  2022cites this paper
• Characterization of Amyloidogenic Peptide Aggregability in Helical Subspace.

  2022cites this paper
• A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils.

  2022cites this paper
• Computational Investigation of Conformational Fluctuations of Aβ42 Monomers in Aqueous Ionic Liquid Mixtures

  2022cites this paper
• Second Sphere Interactions in Amyloidogenic Diseases.

  2022cites this paper
• Self-Assembly of Amyloid-Beta (Aβ) Peptides from Solution to Near In Vivo Conditions.

  2022cites this paper
• Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer’s Disease

  2022cites this paper
• Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer’s disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations

  2022influential citation
• Advances in the understanding of protein misfolding and aggregation through molecular dynamics simulation.

  2022cites this paper
• Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity

  2022cites this paper
• Characterization of the Conformations of Amyloid Beta 42 in Solution That May Mediate Its Initial Hydrophobic Aggregation.

  2022cites this paper
• Constructing conformational library for amyloid-β42 dimers as the smallest toxic oligomers using two CHARMM force fields.

  2022cites this paper
• An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure

  2021cites this paper
• Approaches for a Closer Look at Problems of Liquid Membranes with Amyloid-Beta Peptides

  2021cites this paper
• Interactions of the Aβ(1-42) Peptide with Boron Nitride Nanoparticles of Varying Curvature in an Aqueous Medium: Different Pathways to Inhibit β-Sheet Formation.

  2021cites this paper
• Exploring ensemble structures of Alzheimer’s amyloid β (1-42) monomer using linear regression for the MD simulation and NMR chemical shift

  2021cites this paper
• Amyloid aggregation and secondary structure changes of liver cystatin: Acidic denaturation and TFE induced studies

  2021cites this paper
• Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ

  2021cites this paper
• Structural biology of cell surface receptors implicated in Alzheimer’s disease

  2021cites this paper
• The F19W mutation reduces the binding affinity of the transmembrane Aβ11–40 trimer to the membrane bilayer

  2021cites this paper
• Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

  2021cites this paper
• AlphaFold and the amyloid world.

  2021cites this paper
• Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

  2021cites this paper
• Dimerization of α-Synuclein Fragments Studied by Isothermal-Isobaric Replica-Permutation Molecular Dynamics Simulation

  2021cites this paper
• Mutual structural effects of unmodified and pyroglutamylated amyloid β peptides during aggregation

  2021cites this paper
• Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity.

  2021cites this paper
• Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

  2021cites this paper
• Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

  2021cites this paper
• Residue Interaction Network Analysis Predicts a Val24–Ile31 Interaction May be Involved in Preventing Amyloid‐Beta (1–42) Primary Nucleation

  2021cites this paper
• Impact of A2T and D23N Mutations on Tetrameric A42 Barrel within a Dipalmitoylphosphatidylcholine Lipid Bilayer Membrane by Replica Exchange Molecular Dynamics

  2021cites this paper
• The influence of sodium phosphate buffer on the stability of various proteins: Insights into protein-buffer interactions

  2021cites this paper
• Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane

  2021cites this paper
• Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer's Amyloid Beta.

  2021cites this paper
• Analysis tools for single-monomer measurements of self-assembly processes

  2021cites this paper
• Modeling structural interconversion in Alzheimers’ amyloid beta peptide with classical and intrinsically disordered protein force fields

  2021cites this paper
• How Does the Mono-Triazole Derivative Modulate Aβ42 Aggregation and Disrupt a Protofibril Structure: Insights from Molecular Dynamics Simulations

  2020cites this paper
• Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein-Protein Interactions, and Oxidative Stress.

  2020cites this paper
• Emerging Proof of Protein Misfolding and Interaction in Multifactorial Alzheimer's Disease.

  2020cites this paper
• Different inhibitors of Aβ42-induced toxicity have distinct metal-ion dependency.

  2020cites this paper
• The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18

  2020cites this paper
• Differences in the free energies between the excited states of Aβ40 and Aβ42 monomers encode their distinct aggregation propensities

  2020cites this paper
• Unraveling the aggregation dynamics of amyloidogenesis: A data-driven mathematical modeling approach

  2020cites this paper
• Impact of the Astaxanthin, Betanin, and EGCG Compounds on Small Oligomers of Amyloid Aβ40 Peptide

  2020cites this paper
• The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins

  2020cites this paper
• Pairwise-additive and polarizable atomistic force fields for molecular dynamics simulations of proteins.

  2020cites this paper
• Effects of Boron Nitride Nanotube on the Secondary Structure of Aβ(1-42) Trimer: Possible Inhibitory Effect on Amyloid Formation.

  2020cites this paper
• Hlutverk innansameinda-óreiðu í Neuronal Calcium Sensor-1

  2020cites this paper
• Compact fibril-like structure of amyloid β-peptide (1-42) monomers.

  2020cites this paper
• The Role of Counter-Ions in Peptides—An Overview

  2020cites this paper
• Alzheimer's disease-related amyloid β peptide causes structural disordering of lipids and changes the electric properties of a floating bilayer lipid membrane

  2020cites this paper
• Molecular Interaction of Protein-Pigment C-Phycocyanin with Bovine Serum Albumin in a Gomphosis Structure Inhibiting Amyloid Formation

  2020cites this paper
• Investigating the pernicious effects of heparan sulfate in serum amyloid A1 protein aggregation: a structural bioinformatics approach

  2020cites this paper
• Folding dynamics of Aβ42 monomer at pH 4.0–7.5 with and without physiological salt conditions – does the β1 or β2 region fold first?

  2020cites this paper
• α-Synuclein Exhibits Differential Membrane Perturbation, Nucleation, and TLR2 Binding through Its Secondary Structure.

  2020cites this paper
• Molecular basis for the inhibitory effects of 5-hydroxycyclopenicillone on the conformational transition of Aβ40 monomer

  2020cites this paper
• Differences in the free energies between the excited states of Aβ40 and Aβ42 monomers encode their aggregation propensities

  2020cites this paper
• Long-range Regulation of Partially Folded Amyloidogenic Peptides

  2020cites this paper
• Novel D-π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates.

  2020cites this paper
• Structural Characteristics of Monomeric Aβ42 on Fibril in the Early Stage of Secondary Nucleation Process.

  2020cites this paper
• Impact of A2T and D23N Mutations on Tetrameric Aβ42 Barrel within a DPPC Lipid Bilayer Membrane by Replica Exchange Molecular Dynamics.

  2020cites this paper
• C-Terminal Plays as the Possible Nucleation of the Self-Aggregation of the S-Shape Aβ11–42 Tetramer in Solution: Intensive MD Study

  2019cites this paper