Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell Host and Microbe

• Publication date

  2014-01-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.chom.2013.12.001PMID 24439898PMCID PMC3905459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Drosophila JAK-STAT pathway

  2013cited by this paper
• Trypanosome Infection Establishment in the Tsetse Fly Gut Is Influenced by Microbiome-Regulated Host Immune Barriers

  2013cited by this paper
• Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

  2013cited by this paper
• The impact of the gut microbiota on human health: an integrative view.

  2012cited by this paper
• Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.

  2012cited by this paper
• Gut-associated microbes of Drosophila melanogaster

  2012cited by this paper
• Midgut Microbiota of the Malaria Mosquito Vector Anopheles gambiae and Interactions with Plasmodium falciparum Infection

  2012cited by this paper
• Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

  2012cited by this paper
• Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis.

  2012cited by this paper
• Microbiome: The critters within

  2012cited by this paper
• Microbiome influences on insect host vector competence.

  2011cited by this paper
• Assessment of bacterial diversity in the cattle tick Rhipicephalus (Boophilus) microplus through tag-encoded pyrosequencing

  2011cited by this paper
• Unravelling the effects of the environment and host genotype on the gut microbiome

  2011cited by this paper
• Native microbiota shape insect vector competence for human pathogens.

  2011cited by this paper
• Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

  2011influential reference
• Dynamic Gut Microbiome across Life History of the Malaria Mosquito Anopheles gambiae in Kenya

  2011cited by this paper
• Tick innate immunity.

  2010cited by this paper
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut.

  2009cited by this paper
• Bacterial diversity analysis of larvae and adult midgut microflora using culture-dependent and culture-independent methods in lab-reared and field-collected Anopheles stephensi-an Asian malarial vector

  2009cited by this paper
• Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation.

  2009influential reference
• Tissue damage-induced intestinal stem cell division in Drosophila.

  2009cited by this paper
• New insights into peritrophic matrix synthesis, architecture, and function.

  2009cited by this paper
• Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.

  2009influential reference
• Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila.

  2009influential reference
• Insect immunity: from pattern recognition to symbiont-mediated host defense.

  2009cited by this paper
• Worlds within worlds: evolution of the vertebrate gut microbiota

  2008cited by this paper
• Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences

  2008influential reference
• Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks

  2007cited by this paper
• A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector.

  2007cited by this paper
• IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.

  2007cited by this paper
• Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein.

  2006cited by this paper
• JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions

  2006cited by this paper
• Identification and molecular characterization of a peritrophin-like protein from fleshy prawn (Fenneropenaeus chinensis).

  2006cited by this paper
• Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig.

  2006cited by this paper
• Biology of Disease Vectors

  2005cited by this paper
• Identification and characterization of a novel peritrophic matrix protein, Ae-Aper50, and the microvillar membrane protein, AEG12, from the mosquito, Aedes aegypti.

  2005cited by this paper
• Genome sequencing in microfabricated high-density picolitre reactors

  2005cited by this paper
• Capillary feeding of specific dsRNA induces silencing of the isac gene in nymphal Ixodes scapularis ticks

  2005cited by this paper
• TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.

  2004cited by this paper
• [Peritrophic matrix in the midgut of tick females of the genus Ixodes (Acari: Ixodidae)].

  2004cited by this paper
• RNA Interference: Applicability in Tick Research

  2004cited by this paper
• The roles of JAK/STAT signaling in Drosophila immune responses

  2004influential reference
• [Peritrophic matrix in the midgut of tick females of the genus Ixodes (Acari: Ixodidae)].

  2004cited by this paper
• Glass Capillary Tube Feeding: A Method for Infecting Nymphal Ixodes scapularis (Acari: Ixodidae) with The Lyme Disease Spirochete Borrelia burgdorferi

  2002cited by this paper
• Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway.

  2002influential reference
• Pro-oxidant and cytotoxic effects of circulating heme.

  2002influential reference
• Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands.

  2001cited by this paper
• Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells.

  2001cited by this paper
• Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis

  2001cited by this paper
• Papel de Lactobacillus como factor protector de la candidiasis vaginal

  2001cited by this paper
• [Role of Lactobacillus as protector against vaginal candidiasis].

  2001cited by this paper
• The roles of the Drosophila JAK/STAT pathway

  2000cited by this paper
• Infectious Diseases and Arthropods

  1999cited by this paper
• Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

  1998cited by this paper
• A novel antimicrobial activity of a Paenibacillus polymyxa strain isolated from regional fermented sausages

  1998cited by this paper
• Isolation of aerobic microbes from Ixodes scapularis (Acari: Ixodidae), the vector of Lyme disease in the eastern United States.

  1998cited by this paper
• Peritrophic matrix structure and function.

  1997cited by this paper
• Peritrophic matrix structure and function.

  1997cited by this paper
• Cellular and molecular interrelationships between ticks and prokaryotic tick-borne pathogens.

  1995cited by this paper
• Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

  1995cited by this paper
• The biological and social phenomenon of Lyme disease.

  1993cited by this paper
• Histotechnology: A Self-Instructional Text

  1990cited by this paper
• Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities.

  1977cited by this paper

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  2026cites this paper
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  2026cites this paper
• Gut microbiota landscape of Haemaphysalis longicornis under Borrelia burgdorferi infection.

  2026cites this paper
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  2026cites this paper
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  2026cites this paper
• Unlocking the Black Box: The Molecular Dialogue Between ASFV and Its Tick Host

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  2025cites this paper
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• Decoding Microbial Community Assembly: Insights on Vectors of Infectious Diseases.

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• Immune-mediated indirect interaction between gut microbiota and bacterial pathogens

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• Peritrophic matrix: an important determinant of vector competence in hematophagous arthropods.

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• Entomopathogenic Fungi as Alternatives to Chemical Acaricides: Challenges, Opportunities and Prospects for Sustainable Tick Control

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper