Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Bioessays

• Publication date

  2017-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1002/bies.201600177PMID 28044359PMCID PMC5304421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Behavioral Health Trends in the United States: Results from the 2014 National Survey on Drug Use and Health

  2017cited by this paper
• Eukaryotic V-ATPase and Its Super-complexes: From Structure and Function to Disease and Drug Targeting

  2016cited by this paper
• Mental Disorders Top The List Of The Most Costly Conditions In The United States: $201 Billion.

  2016cited by this paper
• Metabolic regulation of mitochondrial dynamics

  2016cited by this paper
• LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons

  2016cited by this paper
• An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration.

  2016cited by this paper
• Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium

  2016influential reference
• Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.

  2016cited by this paper
• Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome.

  2016cited by this paper
• Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.

  2016cited by this paper
• Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function.

  2016cited by this paper
• Neuronal vs glial glutamate uptake: Resolving the conundrum.

  2016cited by this paper
• Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

  2016cited by this paper
• Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy.

  2016influential reference
• System-based proteomic and metabonomic analysis of the Df(16)A+/− mouse identifies potential miR-185 targets and molecular pathway alterations

  2016cited by this paper
• The interneuron energy hypothesis: Implications for brain disease.

  2016cited by this paper
• Neuropsychiatric Features in Primary Mitochondrial Disease.

  2016cited by this paper
• Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths

  2016cited by this paper
• Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles

  2016cited by this paper
• The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

  2015influential reference
• Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

  2015cited by this paper
• Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia

  2015cited by this paper
• Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

  2015cited by this paper
• DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

  2015cited by this paper
• Palmitoylation and depalmitoylation defects

  2015cited by this paper
• Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.

  2015cited by this paper
• The molecular era of the mitochondrial calcium uniporter

  2015cited by this paper
• Mitochondrial ROS metabolism: 10 Years later

  2015cited by this paper
• Tasks for inhibitory interneurons in intact brain circuits.

  2015cited by this paper
• Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

  2015cited by this paper
• Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome*

  2015cited by this paper
• Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory.

  2014cited by this paper
• Mitochondrial trafficking and anchoring in neurons: New insight and implications

  2014cited by this paper
• Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

  2014influential reference
• Biological Insights From 108 Schizophrenia-Associated Genetic Loci

  2014cited by this paper
• Mitochondrial dysfunction in central nervous system white matter disorders

  2014cited by this paper
• MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond.

  2014cited by this paper
• Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome.

  2014cited by this paper
• Activity-driven local ATP synthesis is required for synaptic function.

  2014cited by this paper
• The 22q11.2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan.

  2014cited by this paper
• Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

  2014cited by this paper
• Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models

  2014cited by this paper
• The complete structure of the large subunit of the mammalian mitochondrial ribosome

  2014cited by this paper
• Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

  2013cited by this paper
• The hallmarks of aging.

  2013cited by this paper
• Ultra-sensitive fluorescent proteins for imaging neuronal activity

  2013cited by this paper
• Architecture of the large subunit of the mammalian mitochondrial ribosome

  2013cited by this paper
• MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

  2013influential reference
• Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia

  2013cited by this paper
• DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

  2013cited by this paper
• A Synaptic Function Approach to Investigating Complex Psychiatric Diseases

  2013cited by this paper
• Expression of autism spectrum and schizophrenia in patients with a 22q11.2 deletion.

  2013cited by this paper
• The mitochondrial transporter family SLC25: identification, properties and physiopathology.

  2013influential reference
• Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

  2013cited by this paper
• Mitochondrial trafficking in neurons.

  2013cited by this paper
• Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter

  2013cited by this paper
• Greasing the synaptic vesicle cycle by membrane lipids.

  2013cited by this paper
• Mitochondria as sensors and regulators of calcium signalling

  2012cited by this paper
• Synaptic energy use and supply.

  2012influential reference
• Impaired mitochondrial function in psychiatric disorders

  2012cited by this paper
• Age-Dependent MicroRNA Control of Synaptic Plasticity in 22q11 Deletion Syndrome and Schizophrenia

  2012influential reference
• Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

  2012cited by this paper
• The contribution of thioredoxin-2 reductase and glutathione peroxidase to H(2)O(2) detoxification of rat brain mitochondria.

  2012cited by this paper
• Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia.

  2012cited by this paper
• The permeability transition pore as a Ca2+ release channel: New answers to an old question

  2012cited by this paper
• Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

  2011cited by this paper
• Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons

  2011cited by this paper
• Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

  2011cited by this paper
• Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

  2011cited by this paper
• Practical guidelines for managing patients with 22q11.2 deletion syndrome.

  2011cited by this paper
• Taking a "good" look at free radicals in the aging process.

  2011cited by this paper
• Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study

  2011cited by this paper
• DISC1 at 10: connecting psychiatric genetics and neuroscience.

  2011cited by this paper
• Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome/Velocardiofacial Syndrome)

  2011cited by this paper
• An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities

  2011cited by this paper
• Age-Related Increase in the Number of Oligodendrocytes Is Dysregulated in Schizophrenia and Mood Disorders

  2011cited by this paper
• A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

  2011cited by this paper
• Animal models of neuropsychiatric disorders

  2010cited by this paper
• Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

  2010cited by this paper
• Dysregulation of Presynaptic Calcium and Synaptic Plasticity in a Mouse Model of 22q11 Deletion Syndrome

  2010influential reference
• Elevated prevalence of generalized anxiety disorder in adults with 22q11.2 deletion syndrome.

  2010cited by this paper
• Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome.

  2009cited by this paper
• The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria*

  2009cited by this paper
• The DISC locus in psychiatric illness

  2008cited by this paper
• Chromosome 22q11.2 deletion syndrome: DiGeorge syndrome/velocardiofacial Syndrome.

  2008cited by this paper
• Proline metabolism in health and disease

  2008influential reference
• The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

  2008cited by this paper
• PRODH variants and risk for schizophrenia

  2008cited by this paper
• Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

  2008cited by this paper
• Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes.

  2008influential reference
• The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

  2007cited by this paper
• The glutamate/GABA‐glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

  2006cited by this paper
• Mouse models of 22q11 deletion syndrome.

  2006cited by this paper
• Functional genomics reveals genes involved in protein secretion and Golgi organization

  2006cited by this paper
• Neurocognitive profile in 22q11 deletion syndrome and schizophrenia.

  2006cited by this paper
• Hyperprolinemia is a risk factor for schizoaffective disorder

  2005cited by this paper
• Clinical features of 78 adults with 22q11 deletion syndrome

  2005cited by this paper
• Lipid regulation of the synaptic vesicle cycle

  2005cited by this paper
• Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia

  2004cited by this paper
• Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium

  2004cited by this paper

• Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes

  2026influential citation
• Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits.

  2025cites this paper
• Exploring the Impact of Mitonuclear Discordance on Disease in Latin American Admixed Populations

  2025cites this paper
• mGluR5 as a Potential Orchestrator of Astrocyte Interactions in Neurological Disorders

  2025cites this paper
• Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome.

  2025cites this paper
• How does altered function of the hippocampus contribute to the development of psychosis?

  2025cites this paper
• Pathways to Psychosis: Factors Associated With Risk for Psychosis Spectrum Disorders.

  2025cites this paper
• Brain and behavioural anomalies caused by Tbx1 haploinsufficiency are corrected by vitamin B12

  2024cites this paper
• Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion

  2024cites this paper
• Drug-induced parkinsonism in a patient with DiGeorge syndrome: a case report

  2024cites this paper
• Role of mitochondria‐endoplasmic reticulum contacts in neurodegenerative, neurodevelopmental and neuropsychiatric conditions

  2024cites this paper
• Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11.2 deletion syndrome

  2024cites this paper
• Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior

  2024cites this paper
• Unlocking Neural Function with 3D In Vitro Models: A Technical Review of Self-Assembled, Guided, and Bioprinted Brain Organoids and Their Applications in the Study of Neurodevelopmental and Neurodegenerative Disorders

  2023cites this paper
• The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster

  2023cites this paper
• The mitochondria in schizophrenia with 22q11.2 deletion syndrome: From pathogenesis to therapeutic promise of targeted natural drugs.

  2023cites this paper
• Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?

  2023cites this paper
• Emerging evidence for astrocyte dysfunction in schizophrenia

  2022cites this paper
• Parkinsonism in Genetic Neurodevelopmental Disorders: A Systematic Review

  2022cites this paper
• Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders

  2022cites this paper
• The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

  2021cites this paper
• Contribution of Mitochondrial DNA Heteroplasmy to the Congenital Cardiac and Palatal Phenotypic Variability in Maternally Transmitted 22q11.2 Deletion Syndrome

  2021cites this paper
• Contribution of mitochondrial DNA heteroplasmy to the phenotypic variability in maternally transmitted 22q11.2 deletion syndrome

  2020cites this paper
• Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders

  2020cites this paper
• On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

  2019cites this paper
• Neurobiological perspective of 22q11.2 deletion syndrome.

  2019cites this paper
• Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations

  2019cites this paper
• Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease

  2019cites this paper
• On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease

  2019cites this paper
• Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

  2019cites this paper
• Disruption of the Blood-Brain Barrier in 22q11.2 Deletion Syndrome

  2019cites this paper
• Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia

  2018cites this paper
• Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder

  2018cites this paper
• Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

  2018cites this paper
• 22q11.2 Deletion Syndrome–Associated Parkinson's Disease

  2018cites this paper
• Molecular genetics of 22q11.2 deletion syndrome

  2018cites this paper
• Generation and characterisation of human embryonic stem cells deficient in ZDHHC8, a gene deleted in 22q11.2 deletion syndrome

  2017cites this paper
• Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence

  2017cites this paper
• Emergent, remitted and persistent psychosis-spectrum symptoms in 22q11.2 deletion syndrome

  2017cites this paper
• MicroRNA-338 modulates cortical neuronal placement and polarity

  2017cites this paper
• Our (Mother’s) Mitochondria and Our Mind

  2017cites this paper