Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Thorax

• Publication date

  2010-12-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/thx.2010.154484PMID 21177668
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ethics approval This study was conducted with the approval of the East London and City Health Authority Ethic Committee. Provenance and peer review Not commissioned; externally peer reviewed.

  2011cited by this paper
• Clinical COPD phenotypes: a novel approach using principal component and cluster analyses

  2010cited by this paper
• Pulmonary Physiology and Pathophysiology in Obesity Obesity , adipokines , and lung disease

  2010cited by this paper
• Phenotypic Characterization and Course of Chronic Obstructive Pulmonary Disease in the PAC-COPD Study: Design and Methods

  2009cited by this paper
• Thorax

  2009cited by this paper
• La heterogeneidad fenotpica de la EPOC

  2009cited by this paper
• COPD phenotype description using principal components analysis

  2009cited by this paper
• How to use an article about prognosis.

  2009cited by this paper
• Caracterización fenotípica y evolución de la EPOC en el estudio PAC-COPD: diseño y metodología

  2009cited by this paper
• [Phenotypic characterization and course of chronic obstructive pulmonary disease in the PAC-COPD Study: design and methods].

  2009cited by this paper
• Distinct clinical phenotypes of airways disease defined by cluster analysis

  2009influential reference
• [Phenotypic heterogeneity of chronic obstructive pulmonary disease].

  2009cited by this paper
• Characteristics of patients admitted for the first time for COPD exacerbation.

  2009cited by this paper
• Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index.

  2009cited by this paper
• Early life origins of chronic obstructive pulmonary disease

  2009influential reference
• Phenotypic Heterogeneity of Chronic Obstructive Pulmonary Disease

  2009cited by this paper
• COPD and declining FEV1--time to divide and conquer?

  2008influential reference
• Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

  2007cited by this paper
• From COPD to chronic systemic inflammatory syndrome?

  2007cited by this paper
• A plea to abandon asthma as a disease concept.

  2006cited by this paper
• Asthma: defining of the persistent adult phenotypes.

  2006cited by this paper
• Global Initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease

  2006cited by this paper
• Patient's perception of exacerbations of COPD--the PERCEIVE study.

  2006cited by this paper
• Selection of Variables for Cluster Analysis and Classification Rules

  2006cited by this paper
• Is Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) a Risk Factor for Cardiovascular Events?

  2006cited by this paper
• K-means clustering: a half-century synthesis.

  2006cited by this paper
• Multi‐dimensional phenotyping: towards a new taxonomy for airway disease

  2005cited by this paper
• Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.

  2004cited by this paper
• Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease.

  2004cited by this paper
• Genetics, statistics and human disease: analytical retooling for complexity.

  2004cited by this paper
• The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease.

  2004cited by this paper
• [Respiratory insufficiency].

  2003cited by this paper
• Chronic obstructive pulmonary disease

  2003cited by this paper
• Chronic obstructive pulmonary disease.

  2002cited by this paper
• Selective neck dissection in treatment of node-positive neck cases.

  2001cited by this paper
• Factor Analysis of Quality of Life, Dyspnea, and Physiologic Variables in Patients with Chronic Obstructive Pulmonary Disease Before and After Rehabilitation

  2001cited by this paper
• A factor analysis of dyspnea indexes and lung function parameters in patients with chronic obstructive pulmonary disease.

  2001cited by this paper
• Multiple imputation of missing blood pressure covariates in survival analysis.

  1999cited by this paper
• Chronic Obstructive Pulmonary Disease Stage and Health-Related Quality of Life

  1997cited by this paper
• Chronic obstructive pulmonary disease stage and health-related quality of life. The Quality of Life of Chronic Obstructive Pulmonary Disease Study Group.

  1997cited by this paper
• Users' Guides to the Medical Literature: V. How to Use an Article About Prognosis

  1994cited by this paper
• Users' guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group.

  1994influential reference
• Factor analysis of exercise capacity, dyspnoea ratings and lung function in patients with severe COPD.

  1994cited by this paper
• Users' guides to the medical literature.

  1993cited by this paper
• A factor analysis of dyspnea ratings, respiratory muscle strength, and lung function in patients with chronic obstructive pulmonary disease.

  1992cited by this paper
• Use of factor analysis to consolidate multiple outcome measures in chronic obstructive pulmonary disease.

  1991cited by this paper
• The course and prognosis of different forms of chronic airways obstruction in a sample from the general population.

  1987cited by this paper
• INFERENCE AND MISSING DATA

  1975cited by this paper
• Acute respiratory insufficiency. Treatment with prolonged extracorporeal oxygenation.

  1972cited by this paper
• External electric stimulator for treatment of ventricular standstill.

  1956cited by this paper
• Respiratory insufficiency.

  1955cited by this paper

• Leveraging Deep Learning for Precise Chronic Bronchitis Identification in X-Ray Modalities

  2025cites this paper
• Development and Comparison of Reference Equations for the Six-Minute Walk Test in Spanish Healthy Adults Aged 45-85 Years.

  2025cites this paper
• Identification of clinically meaningful, overlapping obstructive respiratory disease subtypes via data-driven approaches in a primary care population

  2025cites this paper
• TRANSLATING THE MECHANISMS OF HYPOXIA TO LONG-TERM OXYGEN PRESCRIPTION IN COPD: A PROPOSAL.

  2025cites this paper
• Exploring COPD Patient Clusters and Associations with Health-Related Quality of Life Using A Machine Learning Approach: A Nationwide Cross-Sectional Study

  2025cites this paper
• Modern view on clinical phenotyping of chronic obstructive pulmonary disease

  2024cites this paper
• Lung-function trajectories: relevance and implementation in clinical practice.

  2024cites this paper
• Relationship between Severity of Chronic Obstructive Pulmonary Disease and Left Ventricular Diastolic Dysfunction

  2024cites this paper
• Clinical Characteristics of Overweight Patients With Acute Exacerbation Chronic Obstructive Pulmonary Disease (AECOPD)

  2024cites this paper
• Hierarchical clustering in COPD patients: who is at risk of exacerbation?

  2024cites this paper
• Prognostication of co-morbidity clusters on hospitalisation and mortality in advanced COPD.

  2024cites this paper
• Proteomic Blood Profiles Obtained by Totally Blind Biological Clustering in Stable and Exacerbated COPD Patients

  2024cites this paper
• Evaluation of data processing pipelines on real-world electronic health records data for the purpose of measuring patient similarity

  2023cites this paper
• COPD Heterogeneity and Progression: Emphysema-Predominant and Non-Emphysema-Predominant Disease.

  2023cites this paper
• Demystification of artificial intelligence for respiratory clinicians managing patients with obstructive lung diseases

  2023cites this paper
• Influence of nutritional status and body mass index of patients on the prognosis and course of chronic obstructive pulmonary disease

  2023cites this paper
• Joint clinical and molecular subtyping of COPD with variational autoencoders

  2023cites this paper
• Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary.

  2023cites this paper
• COPD and multimorbidity: recognising and addressing a syndemic occurrence.

  2023cites this paper
• Mortality in individuals with COPD on long-term home non-invasive ventilation.

  2023cites this paper
• Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes

  2023cites this paper
• Long-Term Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: Association between Clinical Phenotypes and Survival

  2022cites this paper
• Peripheral neuropathy: A neglected cause of disability in COPD - A narrative review.

  2022cites this paper
• Validation of Clinical COPD Phenotypes for Prognosis of Long-Term Mortality in Swedish and Dutch Cohorts

  2022cites this paper
• Unsupervised Learning Identifies CT Measurements as Primary Drivers of Progression, Exacerbation, and Mortality in COPD.

  2022cites this paper
• Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD)

  2022cites this paper
• Esacerbazioni delle broncopneumopatie croniche ostruttive

  2022cites this paper
• Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers

  2022cites this paper
• Using cluster analysis to describe phenotypical heterogeneity in extremely preterm infants: a retrospective whole-population study

  2022cites this paper
• Evaluation of the multimorbidity network and its relationship with clinical phenotypes in chronic obstructive pulmonary disease: The GALAXIA study

  2022cites this paper
• One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

  2021cites this paper
• Combined unsupervised-supervised machine learning for phenotyping complex diseases with its application to obstructive sleep apnea

  2021cites this paper
• Clinical heterogeneity of a population of patients admitted to the Emergency Department with a diagnosis of COPD-exacerbation: Relevance of cardiovascular comorbidities

  2021cites this paper
• Identification of hub genes and key pathways in the emphysema phenotype of COPD

  2021cites this paper
• Development and validation of the EHS-COPD model to predict sex-specific risk of chronic obstructive pulmonary disease (COPD) in older Chinese adults: Hong Kong’s Elderly Health Service Cohort

  2021cites this paper
• Unravelling the mechanisms driving multimorbidity in COPD to develop holistic approaches to patient-centred care

  2021cites this paper
• Exacerbations des bronchopneumopathies chroniques obstructives

  2021cites this paper
• One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

  2021cites this paper
• Digital Health for Enhanced Understanding and Management of Chronic Conditions: COPD as a Use Case

  2021cites this paper
• One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

  2021cites this paper
• Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

  2021cites this paper
• Comorbidities in Patients With Chronic Obstructive Pulmonary Disease

  2021cites this paper
• Mortality and Exacerbation Risk by Body Mass Index in Patients with COPD in TIOSPIR and UPLIFT

  2021cites this paper
• Interpretable Phenotyping for Electronic Health Records

  2021cites this paper
• Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data

  2020cites this paper
• Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters

  2020cites this paper
• Enhancing Obstructive Sleep Apnea Diagnosis With Screening Through Disease Phenotypes: Algorithm Development and Validation

  2020cites this paper
• Influence of Comorbidities on the Survival of COPD Patients According to Phenotypes

  2020cites this paper
• Cluster-Guided Multiscale Lung Modeling via Machine Learning

  2020cites this paper
• Multimorbidity in Patients with Chronic Obstructive Pulmonary Disease.

  2020cites this paper
• Aspects extrapulmonaires des exacerbations de bronchopneumopathie chronique obstructive

  2020cites this paper
• From systemic effects of COPD to COPD as pulmonary component of multimorbidity

  2020cites this paper
• Somatotypes trajectories during adulthood and their association with COPD phenotypes

  2020cites this paper
• Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil

  2020cites this paper
• Exacerbations des bronchopneumopathies chroniques obstructives

  2020cites this paper
• Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil

  2020cites this paper
• Influence of Comorbidities on the Survival of COPD Patients According to Phenotypes

  2020cites this paper
• Distinguishing smoking related lung disease phenotypes via imaging and molecular features.

  2020cites this paper
• Advances in understanding of mechanisms related to increased cardiovascular risk in COPD

  2020cites this paper
• 'HIGH RISK' CLINICAL AND INFLAMMATORY CLUSTERS IN COPD OF CHINESE DESCENT.

  2020cites this paper
• Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil

  2020cites this paper
• Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients

  2020cites this paper
• COPD phenotypes and machine learning cluster analysis: A systematic review and future research agenda.

  2020influential citation
• Enhancing Obstructive Sleep Apnea Diagnosis With Screening Through Disease Phenotypes: Algorithm Development and Validation (Preprint)

  2020cites this paper
• Somatotypes trajectories during adulthood and its association with Chronic Obstructive Pulmonary Disease (COPD) phenotypes

  2020cites this paper
• Influence of Comorbidities on the Survival of COPD Patients According to Phenotypes

  2020cites this paper
• Comprehensive Cluster Analysis for COPD Including Systemic and Airway Inflammatory Markers

  2020cites this paper
• Metabolic profiles among COPD and controls in the CanCOLD population-based cohort

  2020cites this paper
• Comorbidity-Based Clusters Contain Chaos in COPD.

  2020cites this paper
• COPD classification models and mortality prediction capacity

  2019cites this paper
• Asthma in electronic health records : validity and phenotyping

  2019cites this paper
• Predictive factors for COPD exacerbations and mortality in patients with overlap syndrome

  2019cites this paper
• The effect of isolated nocturnal oxygen desaturations on serum hs‐CRP and IL‐6 in patients with chronic obstructive pulmonary disease

  2019cites this paper
• European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD

  2019cites this paper
• Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case–Control Study With Follow-Up

  2019cites this paper
• Low Liver Density Is Linked to Cardiovascular Comorbidity in COPD: An ECLIPSE Cohort Analysis of COPD Longitudinally to Identify Predictive Surrogate Endpoints

  2019cites this paper
• Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case-Control Study with Follow-up.

  2019cites this paper
• Physical Activity Is Associated with Attenuated Disease Progression in Chronic Obstructive Pulmonary Disease

  2019cites this paper
• Patients With Chronic Obstructive Pulmonary Disease Exacerbations: Recommendations for Diagnosis, Treatment and Care

  2019cites this paper
• The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease.

  2019cites this paper
• Usefulness of Biological Clustering Patterns in Chronic Obstructive Pulmonary Disease

  2019influential citation
• eview he Excessive Use of Inhaled Corticosteroids in Chronic Obstructive ulmonary Disease

  2019cites this paper
• Machine Learning Characterization of COPD Subtypes: Insights from the COPDGene Study.

  2019cites this paper
• Low Liver Density Is Linked to Cardiovascular Comorbidity in COPD: An ECLIPSE Cohort Analysis

  2019cites this paper
• INVITED REVIEW SERIES: Rehabilitation in chronic respiratory diseases.

  2019cites this paper
• Low Body Mass Index Is Associated with Higher Odds of COPD and Lower Lung Function in Low- and Middle-Income Countries

  2019cites this paper
• Stress echocardiography for left ventricular diastolic dysfunction detection in patients with non-severe chronic obstructive pulmonary disease: a cross-sectional study

  2019cites this paper
• "Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art."

  2019cites this paper
• Identification of Pleural Response Patterns: A Cluster Analysis.

  2019cites this paper
• Treatable traits in acute exacerbations of chronic airway diseases

  2019influential citation
• The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease

  2019cites this paper
• IMPACT OF FAMILY MEDICINE ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) MANAGEMENT

  2019cites this paper
• Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink)

  2019cites this paper
• Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

  2019cites this paper
• Patients with Chronic Obstructive Pulmonary Disease Exacerbations: Recommendations for Diagnosis, Treatment and Care.

  2019cites this paper
• Low Liver Density Is Linked to Cardiovascular Comorbidity in COPD: An ECLIPSE Cohort Analysis of COPD Longitudinally to Identify Predictive Surrogate Endpoints

  2019cites this paper
• Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort

  2018cites this paper
• The importance of symptoms in the longitudinal variability of clusters in COPD patients: A validation study

  2018cites this paper
• Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS

  2018cites this paper
• Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics

  2018cites this paper