Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Drug Discovery Today

• Publication date

  2017-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.drudis.2017.08.001PMID 28789906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitamin E for Alzheimer's dementia and mild cognitive impairment.

  2017cited by this paper
• Cancer statistics, 2017

  2017cited by this paper
• Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats

  2017cited by this paper
• Is vitamin E an anti-allergic compound?

  2016cited by this paper
• Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol.

  2016cited by this paper
• Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

  2016cited by this paper
• Targeting transcription factor STAT3 for cancer prevention and therapy.

  2016cited by this paper
• Interaction of vitamin E isoforms on asthma and allergic airway disease

  2016cited by this paper
• Vitamin E: A Role in Signal Transduction.

  2015cited by this paper
• Liposomal delivery systems for anti-cancer analogues of vitamin E.

  2015cited by this paper
• Nuts and legume seeds for cardiovascular risk reduction: scientific evidence and mechanisms of action.

  2015cited by this paper
• Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats.

  2015cited by this paper
• HPLC Separation of Vitamin E and Its Oxidation Products and Effects of Oxidized Tocotrienols on the Viability of MCF-7 Breast Cancer Cells in Vitro.

  2015cited by this paper
• Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice

  2015cited by this paper
• A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels

  2015cited by this paper
• Thermal reversibility of vitamin E-enriched emulsion-based delivery systems produced using spontaneous emulsification.

  2015cited by this paper
• Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation

  2015cited by this paper
• Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure.

  2015cited by this paper
• Analysis of the intricate relationship between chronic inflammation and cancer.

  2015cited by this paper
• Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly

  2015cited by this paper
• Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials

  2015cited by this paper
• Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion.

  2015cited by this paper
• Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives

  2015cited by this paper
• Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis

  2015cited by this paper
• Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility

  2015cited by this paper
• Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural biopolymers: Whey protein isolate and gum arabic.

  2015cited by this paper
• Vitamin E-TPGS stabilized self-assembled tripeptide nanostructures for drug delivery.

  2015cited by this paper
• Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites

  2015cited by this paper
• Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats

  2015cited by this paper
• Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury

  2015cited by this paper
• Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells.

  2015cited by this paper
• In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer.

  2015cited by this paper
• Anti-inflammatory Dietary Interventions and Supplements to Improve Performance during Athletic Training

  2015cited by this paper
• Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation.

  2015cited by this paper
• Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors.

  2015cited by this paper
• Adherence to cancer prevention recommendations and antioxidant and inflammatory status in premenopausal women

  2015cited by this paper
• Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines

  2014cited by this paper
• γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model

  2014cited by this paper
• Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice

  2014cited by this paper
• Rice bran enzymatic extract-supplemented diets modulate adipose tissue inflammation markers in Zucker rats.

  2014cited by this paper
• Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice.

  2014cited by this paper
• Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter

  2014cited by this paper
• α-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells.

  2014cited by this paper
• The Effects of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation, and Nitrosative Stress in Patients with Type 2 Diabetes: A Randomized, Double-blind, Placebo-controlled Trial

  2014cited by this paper
• Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

  2014cited by this paper
• Pharmacological potential of tocotrienols: a review

  2014cited by this paper
• Vitamin E-gene interactions in aging and inflammatory age-related diseases: implications for treatment. A systematic review.

  2014cited by this paper
• Methaneseleninic acid and γ-Tocopherol combination inhibits prostate tumor growth in Vivo in a xenograft mouse model

  2014cited by this paper
• Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla.

  2014cited by this paper
• Antioxidant Status and the Risk of Elevated C-Reactive Protein 12 Years Later

  2014cited by this paper
• Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial

  2013cited by this paper
• Frataxin mRNA Isoforms in FRDA Patients and Normal Subjects: Effect of Tocotrienol Supplementation

  2013cited by this paper
• A review of the possible mechanisms of action of tocotrienol - a potential antiosteoporotic agent.

  2013cited by this paper
• Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines.

  2013cited by this paper
• The Photoprotective and Antioxidative Properties of Luteolin are Synergistically Augmented by Tocopherol and Ubiquinone

  2013cited by this paper
• Supplementation with tocotrienol-rich fraction alters the plasma levels of Apolipoprotein A-I precursor, Apolipoprotein E precursor, and C-reactive protein precursor from young and old individuals

  2013cited by this paper
• Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects.

  2013cited by this paper
• Tocotrienols enhance melanosome degradation through endosome docking/fusion proteins in B16F10 melanoma cells.

  2013cited by this paper
• In vivo regulation of gene transcription by alpha and gamma‐tocopherol in murine T lymphocytes

  2013cited by this paper
• The photoprotective and antioxidative properties of the flavonoid luteolin are synergistically augmented by tocopherol and ubiquinone

  2013cited by this paper
• Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures

  2013cited by this paper
• Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2008

  2013cited by this paper
• Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols

  2013cited by this paper
• Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections.

  2012cited by this paper
• Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients.

  2012cited by this paper
• Comparative effects of tocotrienol-rich fraction, α-tocopherol and α-tocopheryl acetate on inflammatory mediators and nuclear factor kappa B expression in mouse peritoneal macrophages.

  2012cited by this paper
• First Evidence That γ-Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF-κB Pathway

  2012cited by this paper
• Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)

  2012cited by this paper
• Discovering the link between nutrition and skin aging

  2012cited by this paper
• γ-Tocopherol inhibits human prostate cancer cell proliferation by up-regulation of transglutaminase 2 and down-regulation of cyclins

  2012cited by this paper
• Vitamin E for Alzheimer's dementia and mild cognitive impairment.

  2012cited by this paper
• γ‐Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro‐apoptotic and chemosensitizing agent

  2011cited by this paper
• Tocotrienols fight cancer by targeting multiple cell signaling pathways

  2011cited by this paper
• The impact of dietary changes and dietary supplements on lipid profile.

  2011cited by this paper
• Tocotrienols and its role in cardiovascular health--a lead for drug design.

  2011cited by this paper
• Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells.

  2011cited by this paper
• α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73

  2011cited by this paper
• Protective Effect of Dietary Tocotrienols against Infection and Inflammation‐induced Hyperlipidemia: An In Vivo and In Silico Study

  2011cited by this paper
• Tocotrienols and cardiovascular health.

  2011cited by this paper
• Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers

  2011cited by this paper
• Natural Vitamin E &agr;-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

  2011cited by this paper
• An in vivo and in silico approach to elucidate the tocotrienol-mediated fortification against infection and inflammation induced alterations in antioxidant defense system.

  2011cited by this paper
• Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction.

  2010cited by this paper
• Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

  2010cited by this paper
• Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells.

  2010cited by this paper
• Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors.

  2010cited by this paper
• Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease

  2010cited by this paper
• Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.

  2010cited by this paper
• Tocotrienols are good adjuvants for developing cancer vaccines

  2010cited by this paper
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.

  2010cited by this paper
• Role of NF-kappaB in the anti-inflammatory effects of tocotrienols.

  2010cited by this paper
• gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line.

  2010cited by this paper
• Tocotrienols Inhibited Growth and Induced Apoptosis in Human HeLa Cells Through the Cell Cycle Signaling Pathway

  2010cited by this paper
• Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors.

  2010cited by this paper
• In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma.

  2010cited by this paper
• Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

  2010cited by this paper
• Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults.

  2010cited by this paper
• Anti‐proliferative effects of γ‐tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression

  2010cited by this paper
• Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling.

  2010cited by this paper
• Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.

  2010cited by this paper

• Therapeutic potential of red palm oil as antioxidant for men's health

  2025cites this paper
• Autophagy in disease management: Exploring the potential of natural products as targeted therapies.

  2025cites this paper
• Rare Prenyllipids in Wild St. John’s Wort During Three Harvest Seasons

  2025cites this paper
• Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome.

  2025cites this paper
• Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation

  2025cites this paper
• Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis

  2025cites this paper
• Enhancing Meat Emulsion Gels with Soy Protein Fibril and Red Palm Oil Pickering Emulsions: The Role of Emulsification Techniques in Chicken Fat Substitution

  2025cites this paper
• Mechanistic Insights into Antioxidant Interventions Targeting Obesity-Induced Oxidative Stress in the Pathogenesis and Complications of Type 2 Diabetes Mellitus

  2025cites this paper
• Tocotrienol isoforms: The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials.

  2024cites this paper
• Supplementation of 500 mg kg–1 Tocotrienol-Rich Fraction (TRF) in Mice Induced Alteration in Liver Protein Expression

  2024cites this paper
• Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

  2024influential citation
• Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology

  2024cites this paper
• Tocotrienol-Rich Fraction Attenuates Blue Light-Induced Oxidative Stress and Melanogenesis in B16-F1 Melanocytes via Anti-Oxidative and Anti-Tyrosinase Properties

  2023cites this paper
• Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art

  2023cites this paper
• Cycloastragenol exerts protective effects against UVB irradiation in human dermal fibroblasts and HaCaT keratinocytes.

  2023cites this paper
• Utilization of antioxidants and anti-inflammatory compounds in managing SARS-CoV-2 infection to achieve healthy community: A review

  2023cites this paper
• Engineered Saccharomyces cerevisiae for de novo δ-tocotrienol biosynthesis

  2023cites this paper
• Anti-fibrotic effect of tocotrienols for bladder dysfunction due to partial bladder outlet obstruction

  2023cites this paper
• Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

  2023cites this paper
• Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far?

  2023cites this paper
• Green Extraction of Valuable Compounds from Rubber Seed Trees: A Path to Sustainability

  2023cites this paper
• Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

  2023cites this paper
• Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies.

  2022cites this paper
• Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I

  2022cites this paper
• Tocotrienol in the Treatment of Topical Wounds: Recent Updates

  2022cites this paper
• Role of Vitamin E in Neonatal Neuroprotection: A Comprehensive Narrative Review

  2022cites this paper
• Mechanism of Action of Tumorigenesis of Anticancer Molecules of Palm Oil Tocotrienols (Elaeis Guieensis Jacq.): A Systematic Review

  2022cites this paper
• Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia

  2022cites this paper
• Revisiting the therapeutic potential of tocotrienol

  2022cites this paper
• Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk

  2022cites this paper
• Pharmaceutical Applications of Vitamin E TPGS

  2021cites this paper
• Tocotrienol: An Underrated Isomer of Vitamin E in Health and Diseases

  2021cites this paper
• Tocotrienols as an Anti-Breast Cancer Agent

  2021cites this paper
• The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer.

  2021cites this paper
• Vitamin E as an essential micronutrient for human health: Common, novel, and unexplored dietary sources.

  2021cites this paper
• Oil Palm

  2021cites this paper
• Vitamins (C, D and E) Against Cancer

  2021cites this paper
• Tocotrienols protect differentiated SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and dopamine receptor D2 gene expression.

  2021cites this paper
• Synthetic Antioxidants

  2020cites this paper
• Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability

  2020cites this paper
• The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

  2020cites this paper
• Inhibition mechanism of 3-hydroxy, 3-methyl glutaryl CoA reductase by tocotrienol-rich rice bran fraction optimally extracted with ultrasonic energy.

  2020cites this paper
• Update on the Anti-Cancer Potency of Tocotrienols and α-Tocopheryl Polyethylene Glycol 1000 Succinate on Leukemic Cell Lines

  2020cites this paper
• Healing Properties of Epidermal Growth Factor and Tocotrienol-Rich Fraction in Deep Partial-Thickness Experimental Burn Wounds

  2020cites this paper
• γ-Tocotrienol and α-Tocopherol Ether Acetate Enhance Docetaxel Activity in Drug-Resistant Prostate Cancer Cells

  2020cites this paper
• Piceatannol: A Natural Stilbene for the Prevention and Treatment of Cancer.

  2020cites this paper
• Application of ɑ-Tocotrienol-Loaded Biocompatible Precirol in Attenuation of Doxorubicin Dose-Dependent Behavior in HUH-7 Hepatocarcinoma Cell Line

  2020cites this paper
• DESENVOLVIMENTO DA PANC Amaranthus hybridus L. (CARURU-ROXO) EM DIFERENTES CONDIÇÕES

  2020cites this paper
• Modulatory role of HMG-CoA reductase inhibitors and ezetimibe on LDL-AGEs-induced ROS generation and RAGE-associated signalling in HEK-293 Cells.

  2019cites this paper
• An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases

  2019cites this paper
• Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols

  2019cites this paper
• Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

  2019cites this paper
• Potential application of zerumbone in the prevention and therapy of chronic human diseases

  2019cites this paper
• Potential of Zerumbone as an Anti-Cancer Agent

  2019cites this paper
• γ-Tocotrienol inhibits oxidative phosphorylation and triggers apoptosis by inhibiting mitochondrial complex I subunit NDUFB8 and complex II subunit SDHB.

  2019cites this paper
• Targeting autophagy using natural compounds for cancer prevention and therapy

  2019cites this paper
• Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements

  2019cites this paper
• Vitamin E and Hip Fractures: An Underused Prevention Strategy?

  2019cites this paper
• Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models.

  2019cites this paper
• Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity.

  2019cites this paper
• Vitamin Status and Mineralized Tissue Formation

  2019cites this paper
• Antiglycation study of HMG-R inhibitors and tocotrienol against glycated BSA and LDL: A comparative study.

  2018cites this paper
• Zein-polysaccharide nanoparticles as matrices for antioxidant compounds: A strategy for prevention of chronic degenerative diseases.

  2018cites this paper
• Influence of protamine shell on nanoemulsions as a carrier for cyclosporine-A skin delivery

  2018cites this paper
• Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?

  2018cites this paper
• Tocotrienols: The promising analogues of vitamin E for cancer therapeutics

  2018influential citation
• δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

  2018cites this paper
• Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

  2018cites this paper
• Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications

  2018cites this paper