Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Angewandte Chemie

• Publication date

  2007-11-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/ANIE.200703386PMID 17886826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

  2007cited by this paper
• Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.

  2007cited by this paper
• Mutational Analysis Reveals That All Tailoring Region Genes Are Required for Production of Polyketide Antibiotic Mupirocin by Pseudomonas fluorescens

  2007cited by this paper
• PksS from Bacillus subtilis is a cytochrome P450 involved in bacillaene metabolism.

  2007cited by this paper
• Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.

  2007cited by this paper
• 3‐Hydroxy‐3‐Methylglutaryl‐CoA‐Like Synthases Direct the Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin A

  2007cited by this paper
• A singular enzymatic megacomplex from Bacillus subtilis

  2007cited by this paper
• Cover Picture: A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the Fungus Rhizopus microsporus (ChemBioChem 1/2007)

  2007cited by this paper
• Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56.

  2006cited by this paper
• Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.

  2006cited by this paper
• Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42

  2006cited by this paper
• Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.

  2006cited by this paper
• Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.

  2004cited by this paper
• Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.

  2004cited by this paper
• Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

  2003cited by this paper
• Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

  2003cited by this paper
• Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.

  2003cited by this paper
• A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

  2002cited by this paper
• Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

  2001cited by this paper
• The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase.

  1999cited by this paper
• Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

  1999cited by this paper
• Bacillaene, a novel inhibitor of procaryotic protein synthesis produced by Bacillus subtilis: production, taxonomy, isolation, physico-chemical characterization and biological activity.

  1995cited by this paper
• Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.

  1995cited by this paper
• A Bacillus subtilis large ORF coding for a polypeptide highly similar to polyketide synthases.

  1993cited by this paper

• Targeted Discovery of β-Branched Conjugated Polyketides from Bacteria Based on Genomic and Metabolomic Hallmarks

  2026cites this paper
• Bacillus ayatagriensis sp. nov., a novel plant growth-promoting rhizobacteria strain isolated from mulberry rhizosphere

  2025cites this paper
• Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases.

  2025cites this paper
• Substrate specificity of a ketosynthase domain involved in bacillaene biosynthesis

  2024cites this paper
• Bioengineering Bacillus spp. for Sustainable Crop Production: Recent Advances and Resources for Biotechnological Applications

  2024cites this paper
• Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B

  2024cites this paper
• Mechanism of a novel Bacillus subtilis JNF2 in suppressing Fusarium oxysporum f. sp. cucumerium and enhancing cucumber growth

  2024cites this paper
• Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases

  2024cites this paper
• Exploring antimycobacterial potential and profiling secondary metabolite gene clusters in the whole genome of Bacillus isolated from dogfruit (Archidendron pauciflorum)

  2024cites this paper
• Draft genome sequence of potato crop bacterial isolates and nanoparticles-intervention for the induction of secondary metabolites biosynthesis

  2023cites this paper
• Bacillaene, sharp objects consist in the arsenal of antibiotics produced by Bacillus

  2023cites this paper
• Biosynthesis of trans-AT PKS-Derived Shuangdaolides Featuring a trans-acting Enzyme for Online Epoxidation.

  2023cites this paper
• Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus

  2023cites this paper
• Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis.

  2023cites this paper
• More than just an eagle killer: The freshwater cyanobacterium Aetokthonos hydrillicola produces highly toxic dolastatin derivatives

  2023cites this paper
• Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

  2022cites this paper
• Culturable bacteria diversity in stem liquid and resina from Populus euphratica and screening of plant growth-promoting bacteria

  2022cites this paper
• Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.

  2021cites this paper
• Hidden Treasures: Microbial Natural Product Biosynthesis off the Beaten Path

  2021cites this paper
• The Mechanism of Dehydrating Bimodules in trans‐Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin

  2021cites this paper
• Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian

  2021cites this paper
• Cis double bond formation in polyketide biosynthesis.

  2021cites this paper
• Bacillaenes: Decomposition Trigger Point and Biofilm Enhancement in Bacillus

  2021cites this paper
• Comprehensive genomic analysis of Bacillus subtilis 9407 reveals its biocontrol potential against bacterial fruit blotch

  2021cites this paper
• Cytosine Base Editor-Mediated Multiplex Genome Editing to Accelerate Discovery of Novel Antibiotics in Bacillus subtilis and Paenibacillus polymyxa

  2021cites this paper
• Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential

  2021cites this paper
• Polyketides Are Agents for Probiotics Antagonizing Pathogenic Microbiota

  2021cites this paper
• The chemical ecology of the fungus-farming termite symbiosis

  2021cites this paper
• Der Mechanismus von dehydatisierenden Bimodulen in der trans ‐Acyltransferase‐Polketidbiosynthese: Eine Modellstudie am hepatoprotektiven Hangtaimycin

  2021cites this paper
• Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential

  2020cites this paper
• Polyketide β-branching: diversity, mechanism and selectivity.

  2020cites this paper
• Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation

  2020cites this paper
• Genomic insights into the phylogeny of Bacillus strains and elucidation of their secondary metabolic potential.

  2020cites this paper
• Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes

  2020cites this paper
• Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

  2020cites this paper
• New approaches for antituberculosis leads from Actinobacteria.

  2020cites this paper
• Functional genome annotation depicts probiotic properties of Bacillus velezensis FTC01.

  2019cites this paper
• Antimicrobial secondary metabolites from agriculturally important bacteria as next-generation pesticides

  2019cites this paper
• An Effective Strategy for Identification of Highly Unstable Bacillaenes.

  2019cites this paper
• Resorcylic Acid Lactone Thioesterases as Potential Biocatalysts

  2019cites this paper
• Identification of crucial bottlenecks in engineered polyketide biosynthesis.

  2019cites this paper
• Secondary Metabolites of the Plant Growth Promoting Model Rhizobacterium Bacillus velezensis FZB42 Are Involved in Direct Suppression of Plant Pathogens and in Stimulation of Plant-Induced Systemic Resistance

  2019cites this paper
• Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales

  2019cites this paper
• Predicting the peculiar

  2019cites this paper
• Overview of the Antimicrobial Compounds Produced by Members of the Bacillus subtilis Group

  2019cites this paper
• Condensation-Incompetent Ketosynthase Inhibits trans-Acyltransferase Activity.

  2019cites this paper
• Bioactive Secondary Metabolites from Bacillus subtilis: A Comprehensive Review.

  2019cites this paper
• Automated structure prediction of trans-acyltransferase polyketide synthase products

  2019cites this paper
• A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

  2018cites this paper
• Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases.

  2018cites this paper
• Antibacterial aryl‐crowned polyketide from Bacillus subtilis associated with seaweed Anthophycus longifolius

  2018cites this paper
• Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."

  2018cites this paper
• Genome Analysis of Vallitalea guaymasensis Strain L81 Isolated from a Deep-Sea Hydrothermal Vent System

  2018cites this paper
• Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group

  2018cites this paper
• Protein-protein interactions in trans-AT polyketide synthases.

  2018cites this paper
• SeaBioTech: From Seabed to Test-Bed: Harvesting the Potential of Marine Biodiversity for Industrial Biotechnology

  2018cites this paper
• Malonylome analysis of rhizobacterium Bacillus amyloliquefaciens FZB42 reveals involvement of lysine malonylation in polyketide synthesis and plant-bacteria interactions.

  2017cites this paper
• Antibacterial polyketides from Bacillus amyloliquefaciens associated with edible red seaweed Laurenciae papillosa.

  2017cites this paper
• Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.

  2017cites this paper
• Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases.

  2017cites this paper
• Unprecedented antioxidative and anti-inflammatory aryl polyketides from the brown seaweed Sargassum wightii.

  2017cites this paper
• Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly

  2016cites this paper
• The Phormidolide Biosynthetic Gene Cluster: A trans‐AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

  2016cites this paper
• Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery

  2016cites this paper
• Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

  2016cites this paper
• Synthesis of Acyl-Acyl Carrier Proteins and Their Use in Studying Polyketide Synthase Enzymology

  2016cites this paper
• Antimicrobials of Bacillus species: mining and engineering

  2016cites this paper
• The Assembly Line Enzymology of Polyketide Biosynthesis.

  2016cites this paper
• Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

  2016cites this paper
• Genome-wide identification and characterization of macrolide glycosyltransferases from a marine-derived Bacillus strain and their phylogenetic distribution.

  2016cites this paper
• Biosynthesis of polyketides by trans-AT polyketide synthases.

  2016cites this paper
• Using Genomics for Natural Product Structure Elucidation.

  2016cites this paper
• Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

  2016cites this paper
• O-heterocyclic derivatives with antibacterial properties from marine bacterium Bacillus subtilis associated with seaweed, Sargassum myriocystum

  2016cites this paper
• Substrate Specificity of Ketosynthase Domains Part III: Elongation-Based Substrate Specificity

  2016cites this paper
• Das Zusammenspiel zwischen einer multifunktionalen Dehydratase-Domäne und einer C-Methyltransferase bewirkt die Doppelbindungsverschiebung in der Ambruticin-Biosynthese

  2016cites this paper
• The Interplay between a Multifunctional Dehydratase Domain and a C-Methyltransferase Effects Olefin Shift in Ambruticin Biosynthesis.

  2016cites this paper
• Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.

  2015cites this paper
• Studies towards secondary metabolite formation in myxobacteria : elucidation of biosynthetic pathways and yield optimization

  2015cites this paper
• Chemical biology: biosynthetic interceptors.

  2015cites this paper
• Bioprospecting of antibacterial metabolites in seaweed associated bacterial flora along the southeast coast of India

  2015influential citation
• Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

  2015cites this paper
• The re-emergence of natural products for drug discovery in the genomics era

  2015cites this paper
• Structural and functional studies of a trans‐acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α‐ and β‐ketoreduction

  2014cites this paper
• Uncovering a Glycosyltransferase Provides Insights into the Glycosylation Step during Macrolactin and Bacillaene Biosynthesis

  2014cites this paper
• Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains.

  2014cites this paper
• High‐Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis

  2014cites this paper
• Spatiotemporal monitoring of the antibiome secreted by Bacillus biofilms on plant roots using MALDI mass spectrometry imaging.

  2014cites this paper
• A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.

  2014cites this paper
• The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi

  2013cites this paper
• Metabolomics and dereplication strategies in natural products.

  2013cites this paper
• Multifactorial control of iteration events in a modular polyketide assembly line.

  2013cites this paper
• Substrate specificity in ketosynthase domains from trans-AT polyketide synthases.

  2013cites this paper
• Studies on key steps controlling biosynthesis of antibiotics thiomarinol and mupirocin

  2013influential citation
• Mechanism Studies on Fungal Type I Highly-Reducing Polyketide Synthases and Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrids

  2013cites this paper
• 83. Comparative Analysis of the Complete Genome Sequence of the Plant Growth-Promoting Bacterium Bacillus amyloliquefaciens FZB42

  2013cites this paper
• Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate

  2013cites this paper
• Labile natural products

  2012cites this paper
• Polyketide proofreading by an acyltransferase-like enzyme.

  2012cites this paper
• Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species.

  2012cites this paper