Inhibition of HIV-1 virus replication using small soluble Tat peptides.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Virology

• Publication date

  2006-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.VIROL.2005.09.062PMID 16289656
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A single intermolecular contact mediates intramolecular stabilization of both RNA and protein.

  2005cited by this paper
• Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.

  2005influential reference
• Antiviral Activity of CYC202 in HIV-1-infected Cells*

  2005cited by this paper
• HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.

  2005cited by this paper
• RNA interference directed to CDK2 inhibits HIV-1 transcription.

  2005influential reference
• HIV-1 Tat Stimulates Transcription Complex Assembly through Recruitment of TBP in the Absence of TAFs

  2005cited by this paper
• Coordination of Transcription Factor Phosphorylation and Histone Methylation by the P-TEFb Kinase during Human Immunodeficiency Virus Type 1 Transcription

  2004influential reference
• Role of viral regulatory and accessory proteins in HIV-1 replication.

  2004cited by this paper
• Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements.

  2004cited by this paper
• Chromatin immunoprecipitation assay.

  2004cited by this paper
• A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor.

  2004cited by this paper
• Aspartate and glutamate mimetic structures in biologically active compounds.

  2004cited by this paper
• Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".

  2004cited by this paper
• RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes

  2003cited by this paper
• Cyclin E ablation in the mouse.

  2003cited by this paper
• RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.

  2003cited by this paper
• Cell proliferation without cyclin E-CDK2.

  2003cited by this paper
• Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

  2003cited by this paper
• The Cyclin E/Cdk2 Substrate and Cajal Body Component p220NPAT Activates Histone Transcription through a Novel LisH-Like Domain

  2003cited by this paper
• Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states.

  2003cited by this paper
• Cdk2 Knockout Mice Are Viable

  2003cited by this paper
• Chromatin remodeling and modification during HIV-1 Tat-activated transcription.

  2003cited by this paper
• HIV-1 Tat Protein Tram-Activates Transcription In Vitro

  2003cited by this paper
• Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

  2002cited by this paper
• Structure-based design of cyclin-dependent kinase inhibitors.

  2002cited by this paper
• Integrating mRNA processing with transcription.

  2002cited by this paper
• Functional coupling of capping and transcription of mRNA.

  2002cited by this paper
• Interactions between Fission Yeast mRNA Capping Enzymes and Elongation Factor Spt5*

  2002cited by this paper
• Effect of Interlukin-1β on proliferation of gastric epithelial cells in culture

  2002influential reference
• Tat stimulates cotranscriptional capping of HIV mRNA.

  2002cited by this paper
• An extensive network of coupling among gene expression machines

  2002cited by this paper
• Modulation of HIV-1 replication by RNA interference

  2002cited by this paper
• Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

  2002cited by this paper
• HIV-1 Tat Interaction with RNA Polymerase II C-terminal Domain (CTD) and a Dynamic Association with CDK2 Induce CTD Phosphorylation and Transcription from HIV-1 Promoter*

  2002influential reference
• RNAi could hold promise in the treatment of HIV.

  2002cited by this paper
• Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors

  2002cited by this paper
• Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation.

  2002cited by this paper
• Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

  2002cited by this paper
• Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

  2002cited by this paper
• Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD.

  2001cited by this paper
• TFIIH Inhibits CDK9 Phosphorylation during Human Immunodeficiency Virus Type 1 Transcription*

  2001cited by this paper
• Pharmacology and clinical experience with saquinavir

  2001cited by this paper
• Antiapoptotic Function of Cdk9 (TAK/P-TEFb) in U937 Promonocytic Cells

  2001cited by this paper
• Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.

  2001cited by this paper
• HIV-1 Tat Protein Interacts with Mammalian Capping Enzyme and Stimulates Capping of TAR RNA*

  2001cited by this paper
• Inhibition of Human Immunodeficiency Virus Type 1 Transcription by Chemical Cyclin-Dependent Kinase Inhibitors

  2001influential reference
• The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.

  2001cited by this paper
• The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

  2001cited by this paper
• Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR

  2000cited by this paper
• Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

  2000cited by this paper
• CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA

  2000cited by this paper
• Requirement for a Kinase-specific Chaperone Pathway in the Production of a Cdk9/Cyclin T1 Heterodimer Responsible for P-TEFb-mediated Tat Stimulation of HIV-1 Transcription*

  2000cited by this paper
• Aspartic protease inhibitors

  2000cited by this paper
• Dynamic association of capping enzymes with transcribing RNA polymerase II.

  2000cited by this paper
• Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties

  2000cited by this paper
• Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.

  2000cited by this paper
• Relief of Two Built-In Autoinhibitory Mechanisms in P-TEFb Is Required for Assembly of a Multicomponent Transcription Elongation Complex at the Human Immunodeficiency Virus Type 1 Promoter

  2000cited by this paper
• Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription

  2000cited by this paper
• Aspartic protease inhibitors. An integrated approach for the design andsynthesis of diaminodiol-based peptidomimetics.

  2000cited by this paper
• Gene Expression Array of HTLV Type 1-Infected T Cells: Up-regulation of Transcription Factors and Cell Cycle Genes

  2000cited by this paper
• Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription.

  1999cited by this paper
• Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.

  1999cited by this paper
• Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression

  1999cited by this paper
• Transcription elongation factor hSPT5 stimulates mRNA capping.

  1999cited by this paper
• Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme.

  1999cited by this paper
• Human and Rodent Transcription Elongation Factor P-TEFb: Interactions with Human Immunodeficiency Virus Type 1 Tat and Carboxy-Terminal Domain Substrate

  1999cited by this paper
• Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo

  1999cited by this paper
• Ab initio protein structure prediction of CASP III targets using ROSETTA

  1999influential reference
• Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors.

  1999cited by this paper
• Inhibition of gene expression in human cells through small molecule-RNA interactions.

  1999cited by this paper
• Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins

  1999cited by this paper
• Tackling Tat.

  1999cited by this paper
• A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition.

  1998cited by this paper
• Identification of cdk2 binding sites on the p27Kip1 cyclin-dependent kinase inhibitor

  1998cited by this paper
• CDK9 (PITALRE): A multifunctional cdc2‐related kinase

  1998cited by this paper
• Transcription elongation factor P‐TEFb mediates Tat activation of HIV‐1 transcription at multiple stages

  1998cited by this paper
• Allosteric interactions between capping enzyme subunits and the RNA polymerase II carboxy-terminal domain.

  1998cited by this paper
• A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

  1998cited by this paper
• Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors.

  1998cited by this paper
• Inhibition of Acute-, Latent-, and Chronic-Phase Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Bistriazoloacridone Analog That Selectively Inhibits HIV-1 Transcription

  1998cited by this paper
• Inhibition of HIV-1 replication by an anti-tat hammerhead ribozyme.

  1998cited by this paper
• Peptidomimetic design.

  1998cited by this paper
• Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

  1998cited by this paper
• Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

  1998cited by this paper
• In vitro selection of HIV-1 TAR variants by the Tat protein.

  1998cited by this paper
• The Ability of Positive Transcription Elongation Factor b To Transactivate Human Immunodeficiency Virus Transcription Depends on a Functional Kinase Domain, Cyclin T1, and Tat

  1998cited by this paper
• Extracellular HIV-1 Tat Protein Induces a Rapid and Selective Activation of Protein Kinase C (PKC)-α, -ϵ, and -ζ Isoforms in PC12 Cells

  1998cited by this paper
• Host factors in the pathogenesis of HIV disease

  1997cited by this paper
• Association of Tat with Purified HIV-1 and HIV-2 Transcription Preinitiation Complexes*

  1997cited by this paper
• Nonphosphorylated Peptide Ligands for the Grb2 Src Homology 2 Domain*

  1997cited by this paper
• HIV‐1 Tat protein can transactivate a heterologous TATAA element independent of viral promoter sequences and the trans‐activation response element

  1997cited by this paper
• The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme

  1997cited by this paper
• Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs.

  1997influential reference
• Fine resolution of histones by two-dimensional polyacrylamide gel electrophoresis: developmental implications.

  1997influential reference
• Host factors in the pathogenesis of HIV disease.

  1996cited by this paper
• Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.

  1996cited by this paper
• The cdk2 binding domain of p27Kip correlates with the inhibition of the kinase activity of cdk2/cyclin complexes.

  1996cited by this paper
• Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex

  1996cited by this paper
• Three functional classes of transcriptional activation domain

  1996cited by this paper
• Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

  1996cited by this paper

• Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.

  2018cites this paper
• HIV-1 Proteins Influence Novelty-Seeking Behavior and Alter Region-Specific Transcriptional Responses to Chronic Nicotine Treatment in HIV-1Tg Rats

  2017cites this paper
• Rôle de l'autophagie sélective au cours de l'infection par le VIH-1 des lymphocytes T CD4

  2016cites this paper
• Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV.

  2016cites this paper
• Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities.

  2015cites this paper
• Targeting Virus-host Interactions of HIV Replication.

  2015cites this paper
• Filled carbon nanotubes in biomedical imaging and drug delivery

  2015cites this paper
• HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference.

  2014cites this paper
• Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4 (cid:2) T Lymphocytes

  2014cites this paper
• Break CDK2/Cyclin E1 Interface Allosterically with Small Peptides

  2014cites this paper
• Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4+ T Lymphocytes

  2014cites this paper
• The Use of Nanotrap Particles Technology in Capturing HIV-1 Virions and Viral Proteins from Infected Cells

  2014cites this paper
• Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.

  2013cites this paper
• RNA Deep Sequencing Analysis Reveals That Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats

  2013cites this paper
• Transcriptome Sequencing of Gene Expression in the Brain of the HIV-1 Transgenic Rat

  2013cites this paper
• SIRT1 Involvement in Virus- Mediated Diseases

  2013cites this paper
• Dynamic mechanism of HIV replication inhibitor peptide encapsulated into carbon nanotubes

  2013cites this paper
• Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat

  2013cites this paper
• Use of ATP analogs to inhibit HIV-1 transcription.

  2012cites this paper
• Strategies to Block HIV Transcription: Focus on Small Molecule Tat Inhibitors

  2012cites this paper
• Behavioral and Molecular Evidence for a Feedback Interaction Between Morphine and HIV-1 Viral Proteins

  2012cites this paper
• The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

  2011cites this paper
• The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART.

  2010cites this paper
• 4. Interface Peptides

  2010cites this paper
• HIV-Tat Protein mediation of NeuroAIDS central nervous system pathology and behavioral deficits

  2010cites this paper
• A novel binding pocket of cyclin‐dependent kinase 2

  2009cites this paper
• Novel HIV-1 therapeutics through targeting altered host cell pathways

  2009cites this paper
• Human Immunodeficiency Virus Type 1 Tat and Rev as Potential Targets for Drug Development

  2009cites this paper
• Cyclin T1 stabilizes expression levels of HIV‐1 Tat in cells

  2009cites this paper
• Effect of transcription peptide inhibitors on HIV-1 replication.

  2008influential citation
• Spatial Learning and Memory in HIV-1 Transgenic Rats

  2007cites this paper
• Immunodeficient Parameters in the HIV-1 Transgenic Rat Model

  2007cites this paper
• Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.

  2006cites this paper
• Role of HIV-1 Infection in Addictive Behavior: A Study of a HIV-1 Transgenic Rat Model

  2006cites this paper