Sex Steroid Hormones and Tumors in Domestic Animals

Sex steroid hormones play a role in the development and control of animal tumours, partic‐ ularly in those arising in their target organs. Due to their incidence and prevalence, mamma‐ ry tumours of female dogs and cats are among the most frequently studied with focus on the role of ovarian oestrogen and progesterone. In these tumours, sex steroid hormones have been shown to act during the three steps of the carcinogenesis cascade: initiation, pro‐ motion and progression. Experimental data have shown the mutagenic effect of oestrogens [1] while epidemiologic and clinical studies highlighted the role of ovarian hormones as pro‐ moters on mammary tumours in both the dog and the cat [2-9]. Finally, oestrogens and pro‐ gesterone further act during tumour progression. Their role in the last two steps of carcinogenesis makes it possible to control the evolution of the disease.

• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  2013-02-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.5772/54324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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