Putting the pH into phosphatidic acid signaling

The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.

• Publication year

  2011

• Venue

  BMC Biology

• Publication date

  2011-12-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1186/1741-7007-9-85PMID 22136116PMCID 3229452
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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