Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  European Journal of Pharmacology

• Publication date

  1994-10-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0922-4106(94)90089-2PMID 7851497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.

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