Emergence of a Convex Trade‐Off between Transmission and Virulence

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Naturalist

• Publication date

  2005-03-24

• Fields of study

  Biology, Mathematics, Medicine, Environmental Science

• Identifiers
  DOI 10.1086/430053PMID 15937740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Evolution of

  2006cited by this paper
• EVOLUTION OF MULTIHOST PARASITES

  2004cited by this paper
• A General Theory for the Evolutionary Dynamics of Virulence

  2004cited by this paper
• Challenging the trade-off model for the evolution of virulence: is virulence management feasible?

  2003cited by this paper
• WITHIN‐HOST PARASITE DYNAMICS, EMERGING TRADE‐OFF, AND EVOLUTION OF VIRULENCE WITH IMMUNE SYSTEM

  2003influential reference
• Sub-lethal effects of pathogens can lead to the evolution of lower virulence in multiple infections

  2003influential reference
• Lung pathology of fatal severe acute respiratory syndrome

  2003cited by this paper
• The effects of host immunity on virulence–transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi

  2003cited by this paper
• Trade-offs and the evolution of virulence of microparasites: do details matter?

  2003cited by this paper
• Modeling host-parasite coevolution: a nested approach based on mechanistic models.

  2002influential reference
• The Evolution of Parasite Virulence, Superinfection, and Host Resistance

  2002cited by this paper
• WITHIN‐HOST POPULATION DYNAMICS AND THE EVOLUTION OF MICROPARASITES IN A HETEROGENEOUS HOST POPULATION

  2002influential reference
• Playing by Different Rules: The Evolution of Virulence in Sterilizing Pathogens

  2002cited by this paper
• The epidemiological consequences of optimisation of the individual host immune response

  2002cited by this paper
• Virulence evolution via host exploitation and toxin production in spore-producing pathogens

  2002cited by this paper
• Small variations in multiple parameters account for wide variations in HIV–1 set–points: a novel modelling approach

  2001cited by this paper
• Imperfect vaccines and the evolution of pathogen virulence

  2001influential reference
• Evolution of parasite virulence against qualitative or quantitative host resistance

  2000cited by this paper
• Bacterial ecology, antibiotics and selection for virulence

  1999cited by this paper
• Selection for high and low virulence in the malaria parasite

  1999influential reference
• GENETIC RELATIONSHIPS BETWEEN PARASITE VIRULENCE AND TRANSMISSION IN THE RODENT MALARIA PLASMODIUM CHABAUDI

  1999influential reference
• Virulence evolution in a virus obeys a trade off

  1999cited by this paper
• Host haematological factors influencing the transmission of Plasmodium falciparum gametocytes to Anopheles gambiae s.s. mosquitoes

  1999cited by this paper
• Coevolution of recovery ability and virulence

  1998influential reference
• Coevolution of recovery ability and virulence.

  1998cited by this paper
• Virulence and transmissibility of pathogens: what is the relationship?

  1997cited by this paper
• Antibiotic resistance spread in food

  1997cited by this paper
• Mathematical models of parasite responses to host immune defences

  1997cited by this paper
• Copyright � 1997, American Society for Microbiology Human Immunodeficiency Virus Drug Therapy and Virus Load

  1996cited by this paper
• Towards a general function describing T cell proliferation.

  1995cited by this paper
• The Dynamics of Multiple Infection and the Evolution of Virulence

  1995cited by this paper
• Short-sighted evolution and the virulence of pathogenic microorganisms.

  1994cited by this paper
• Virulence and Local Adaptation of a Horizontally Transmitted Parasite

  1994cited by this paper
• Superinfection and the evolution of parasite virulence.

  1994cited by this paper
• Evolution of Infectious Disease

  1994cited by this paper
• Within-Host Population Dynamics and the Evolution and Maintenance of Microparasite Virulence

  1994cited by this paper
• Intra-host versus inter-host selection: viral strategies of immune function impairment.

  1994cited by this paper
• Superinfection and the evolution of parasite virulence

  1994cited by this paper
• Genes necessary for expression of a virulence determinant and for transmission of Plasmodium falciparum are located on a 0.3-megabase region of chromosome 9.

  1993cited by this paper
• Intensive Care Medicine

  1992cited by this paper
• Coexistence and competition in HIV infections.

  1992cited by this paper
• Optimal growth schedule of pathogens within a host: switching between lytic and latent cycles.

  1991influential reference
• The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease.

  1990cited by this paper
• Host-Parasite Relations, Vectors, and the Evolution of Disease Severity

  1983cited by this paper
• A game-theoretical model of parasite virulence.

  1983cited by this paper
• Coevolution of hosts and parasites

  1982influential reference
• Population Biology of Infectious Diseases

  1982cited by this paper
• Population biology of infectious diseases: Part I

  1979cited by this paper
• Population biology of infectious diseases: Part II

  1979cited by this paper

• Evolutionary Stability of High Virulence in Vector-Borne Forest Pathogens: Evidence from Pine Wilt Disease and Management Thresholds

  2026cites this paper
• Virulence Evolution: Thinking Outside of the Host

  2025cites this paper
• A multiscale framework integrating within-host infection kinetics with airborne transmission dynamics

  2025cites this paper
• A continuous-time microparasite model incorporating infection intensity and parasite aggregation

  2025cites this paper
• Evolution into chaos – Implications of the trade-off between transmissibility and immune evasion

  2025cites this paper
• Predicting the evolutionary and epidemiological dynamics of SARS-CoV-2 in South Africa

  2025cites this paper
• Evolution of parasite transmission dispersion

  2025cites this paper
• Dissecting transmission to understand parasite evolution

  2025cites this paper
• Metapopulation heterogeneities in host mobility, productivity, and immunocompetency always increase virulence and infectiousness

  2024cites this paper
• Pathogen evolution following spillover from a resident to a migrant host population depends on interactions between host pace of life and tolerance to infection.

  2024cites this paper
• FdeC expression regulates motility and adhesion of the avian pathogenic Escherichia coli strain IMT5155

  2024cites this paper
• A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution.

  2024cites this paper
• Evolution of infectious diseases induced by epidemic prevention publicity and interaction between heterogeneous strains

  2024cites this paper
• Effect of resistant compartment on pathogen strategy in partially migratory populations

  2024cites this paper
• Death is overrated: the potential role of detection in driving virulence evolution

  2023cites this paper
• Infection burdens and virulence under heat stress: ecological and evolutionary considerations

  2023cites this paper
• Tolerance-conferring defensive symbionts and the evolution of parasite virulence

  2023cites this paper
• Critical View on the Importance of Host Defense Strategies on Virus Distribution of Bee Viruses: What Can We Learn from SARS-CoV-2 Variants?

  2022cites this paper
• Reservoir host immunology and life history shape virulence evolution in 1 zoonotic viruses 2

  2022cites this paper
• The role of a programmatic immune response on the evolution of pathogen traits.

  2021cites this paper
• The competition dynamics of resistant and sensitive infections

  2021cites this paper
• Evolutionary epidemiology consequences of trait-dependent control of heterogeneous parasites

  2021cites this paper
• Reservoir host immunology and life history shape virulence evolution in zoonotic viruses

  2021cites this paper
• Integrating Infection Intensity into Within- and Between-Host Pathogen Dynamics: Implications for Invasion and Virulence Evolution

  2021influential citation
• Detection, not mortality, constrains the evolution of virulence

  2021cites this paper
• The Potential Beneficial Effects of Vaccination on Antigenically Evolving Pathogens

  2021cites this paper
• Antigenic evolution can drive virulence evolution

  2021cites this paper
• Treating symptomatic infections and the co-evolution of virulence and drug resistance

  2020cites this paper
• On the difficult evolutionary transition from the free-living lifestyle to obligate symbiosis

  2020cites this paper
• Optimal Virulence, Diffusion and Tradeoffs

  2020cites this paper
• Évolution de la virulence et COVID-19

  2020cites this paper
• How do toxicants affect epidemiological dynamics?

  2019cites this paper
• Transmission-virulence trade-o ↵ s in vector-borne diseases

  2019cites this paper
• Vaccine-driven virulence evolution: consequences of unbalanced reductions in mortality and transmission and implications for pertussis vaccines

  2019cites this paper
• Impacts of Infections and Predation on Dynamics of Sexually Reproducing Populations

  2019cites this paper
• The interplay between host community structure and pathogen life‐history constraints in driving the evolution of host‐range shifts

  2019cites this paper
• How parasite interaction strategies alter virulence evolution in multi‐parasite communities

  2019influential citation
• The impact of within-host interactions and priority effects on disease dynamics in coinfected populations

  2019cites this paper
• Parasite-induced shifts in host movement may explain the transient coexistence of high- and low-pathogenic disease strains

  2019cites this paper
• Linking sex differences to the evolution of infectious disease life-histories

  2018cites this paper
• Edinburgh Research Explorer Evolution of virulence

  2018cites this paper
• Why multiple infections favour virulent parasites

  2018cites this paper
• Implications écologiques et évolutives du parasitisme sur les structures trophiques

  2018cites this paper
• The evolutionary response of virulence to host heterogeneity: a general model with application to myxomatosis in rabbits co-infected with intestinal helminths

  2018cites this paper
• PE ] 2 1 A pr 2 01 6 The biased evolution of generation time

  2018cites this paper
• Inferring infection hazard in wildlife populations by linking data across individual and population scales

  2017cites this paper
• Vector-Borne Pathogen and Host Evolution in a Structured Immuno-Epidemiological System

  2017cites this paper
• Évolution de la virulence et infections multiples

  2017cites this paper
• Can Ebola Virus evolve to be less virulent in humans?

  2017cites this paper
• The virulence–transmission relationship in an obligate killer holds under diverse epidemiological and ecological conditions, but where is the tradeoff?

  2017cites this paper
• Sexually transmitted infections and mate-finding Allee effects.

  2017cites this paper
• Relative fitness of a generalist parasite on two alternative hosts: a cross‐infestation experiment to test host specialization of the hen flea Ceratophyllus gallinae (Schrank)

  2016cites this paper
• Structural and Practical Identifiability Issues of Immuno-Epidemiological Vector–Host Models with Application to Rift Valley Fever

  2016cites this paper
• Low virulence evolves as a bet-hedging strategy in fluctuating environment

  2015cites this paper
• Adaptive virulence evolution: the good old fitness-based approach.

  2015cites this paper
• Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge

  2015cites this paper
• Competitive outcome of multiple infections in a behavior‐manipulating virus/wasp interaction

  2015cites this paper
• Evolutionary Stability of Minimal Mutation Rates in an Evo-epidemiological Model

  2015influential citation
• The Biased Evolution of Generation Time

  2015cites this paper
• Survival and innovation: The role of mutational robustness in evolution.

  2015cites this paper
• Evolutionary Stability of Minimal Mutation Rates in an Evo-epidemiological Model

  2015cites this paper
• The microbiome mutiny hypothesis: can our microbiome turn against us when we are old or seriously ill?

  2015cites this paper
• The adaptive evolution of virulence: a review of theoretical predictions and empirical tests

  2015cites this paper
• Constraints on adaptation of Escherichia coli to mixed‐resource environments increase over time

  2015cites this paper
• From within-host interactions to epidemiological competition: a general model for multiple infections

  2015cites this paper
• Viral biocontrol: grand experiments in disease emergence and evolution.

  2015cites this paper
• Vertical Transmission Selects for Reduced Virulence in a Plant Virus and for Increased Resistance in the Host

  2014cites this paper
• Evolution of acuteness in pathogen metapopulations: conflicts between “classical” and invasion-persistence trade-offs

  2014cites this paper
• Why have parasites promoting mating success been observed so rarely?

  2014cites this paper
• Adaptive Evolution of Virulence-Related Traits in a Susceptible-Infected Model with Treatment

  2014cites this paper
• Emerging Disease and the Evolution of Virulence: The Case of the 1918–1919 Influenza Pandemic

  2014cites this paper
• A construction method to study the role of incidence in the adaptive dynamics of pathogens with direct and environmental transmission

  2013influential citation
• Seasonality selects for more acutely virulent parasites when virulence is density dependent

  2013cites this paper
• The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

  2013cites this paper
• Co-infection and super-infection models in evolutionary epidemiology

  2013cites this paper
• Dynamics and evolution of infectious diseases

  2013cites this paper
• IMMUNE EVASION AND THE EVOLUTION OF MOLECULAR MIMICRY IN PARASITES

  2013cites this paper
• Evolution of Virulence: Intuitions and Models

  2012cites this paper
• Within-Host Dynamics of Multi-Species Infections: Facilitation, Competition and Virulence

  2012cites this paper
• virulence is density dependent Seasonality selects for more acutely virulent parasites when

  2012cites this paper
• Host Quality and Spatial Patterning in Infections of the Eastern Mudsnail (Ilyanassa obsoleta) by Two Trematodes (Himasthla quissetensis and Zoogonus rubellus)

  2012cites this paper
• Antimalarial Drug Resistance

  2012cites this paper
• Impacts of space, abundance and food web structure on parasite life cycles

  2012cites this paper
• Experimental Evolution of a Bacteriophage Virus Reveals the Trajectory of Adaptation across a Fecundity/Longevity Trade-Off

  2012cites this paper
• A construction method to study the role of incidence in the adaptive dynamics of pathogens with direct and environmental transmission

  2012cites this paper
• New Insights into Virulence Evolution in Multigroup Hosts

  2011cites this paper
• Dirty water and disease: pesticide mediated interactions between Daphnia and their parasites

  2011cites this paper
• Consequences of immunopathology for pathogen virulence evolution and public health: malaria as a case study

  2011cites this paper
• Mathematical Immunology of Infectious Diseases

  2011cites this paper
• Interactions between adaptive mutations in the environment and the consequences for adaptation in Escherichia coli

  2011cites this paper
• BRIDGING SCALES IN THE EVOLUTION OF INFECTIOUS DISEASE LIFE HISTORIES: THEORY

  2011cites this paper
• BRIDGING SCALES IN THE EVOLUTION OF INFECTIOUS DISEASE LIFE HISTORIES: APPLICATION

  2011influential citation
• Cultural Niche Construction and Human Learning Environments: Investigating Sociocultural Perspectives

  2011cites this paper
• Two optimal mutation rates in obligate pathogens subject to deleterious mutation.

  2011cites this paper
• Structure du paysage agricole et risque épidémique, une approche démo-génétique

  2011cites this paper
• The University of Chicago New Insights into Virulence Evolution in Multigroup Hosts . Author ( s ) :

  2011cites this paper
• The prevalence and persistence of sigma virus, a biparentally transmitted parasite of Drosophila melanogaster.

  2011cites this paper
• Evolution of Nutrient Uptake Reveals a Trade‐Off in the Ecological Stoichiometry of Plant‐Herbivore Interactions

  2010cites this paper
• From Grazing Resistance to Pathogenesis: The Coincidental Evolution of Virulence Factors

  2010cites this paper
• Evolution de l'agressivité des champignons phytopathogènes, couplage des approches théorique et empirique

  2010cites this paper