15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Clinical Investigation

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 10903334PMCID PMC314310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis

  2004cited by this paper
• Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

  2000cited by this paper
• The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses1

  2000cited by this paper
• C-myc antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes.

  1999cited by this paper
• Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.

  1999cited by this paper
• Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo *

  1999cited by this paper
• Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes.

  1999cited by this paper
• Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis

  1999cited by this paper
• Inducible cyclooxygenase may have anti-inflammatory properties

  1999cited by this paper
• Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2 *

  1999cited by this paper
• Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2 *

  1999cited by this paper
• PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.

  1999cited by this paper
• Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages*

  1998cited by this paper
• Review: angiogenesis: implications for rheumatoid arthritis.

  1998cited by this paper
• Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

  1998cited by this paper
• A novel antidiabetic drug, troglitazone--reason for hope and concern.

  1998cited by this paper
• PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.

  1998cited by this paper
• Differentiation and reversal of malignant changes in colon cancer through PPARγ

  1998cited by this paper
• Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.

  1998cited by this paper
• The role of nitric oxide in inflammation and immunity.

  1998cited by this paper
• PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.

  1998cited by this paper
• Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.

  1998cited by this paper
• The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.

  1998cited by this paper
• Apoptosis in the rheumatic diseases.

  1997cited by this paper
• Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta.

  1997cited by this paper
• PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

  1997cited by this paper
• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

  1997cited by this paper
• Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

  1997cited by this paper
• Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein.

  1997cited by this paper
• The PPARalpha-leukotriene B4 pathway to inflammation control.

  1996cited by this paper
• Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

  1996cited by this paper
• Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group.

  1996cited by this paper
• Inflammation. Signalling the fat controller.

  1996cited by this paper
• Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates.

  1995cited by this paper
• The nuclear receptor superfamily: the second decade.

  1995cited by this paper
• Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

  1995cited by this paper
• Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

  1994cited by this paper
• Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.

  1994cited by this paper
• Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

  1994cited by this paper
• Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

  1993cited by this paper
• cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.

  1993cited by this paper
• Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

  1993cited by this paper
• In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

  1992cited by this paper
• Biological activities and mechanisms of action of PGJ2 and related compounds: an update.

  1992cited by this paper
• Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

  1992cited by this paper
• Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

  1990cited by this paper
• Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.

  1988cited by this paper
• Synovial processes in rheumatoid arthritis.

  1988cited by this paper
• Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine.

  1988cited by this paper
• The biology and pharmacology of PGD2.

  1988cited by this paper
• Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei.

  1986cited by this paper
• Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis.

  1985cited by this paper
• 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma.

  1984cited by this paper

• Multi-omics and network pharmacology reveal Huayu-Tongbi decoction reduced arthritis-related bone erosion

  2025cites this paper
• Integrating network pharmacology and PPAR signaling with AI-driven drug dynamics to ameliorate rheumatoid arthritis: Insights from Corydalis Decumbentis Rhizoma (Xiatianwu).

  2025cites this paper
• Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy

  2025cites this paper
• RNA sequencing analysis reveals distinct gene expression patterns in infrapatellar fat pads of patients with end-stage osteoarthritis or rheumatoid arthritis.

  2024cites this paper
• PPARs in Clinical Experimental Medicine after 35 Years of Worldwide Scientific Investigations and Medical Experiments

  2024cites this paper
• The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review

  2024cites this paper
• Increased n-6 Polyunsaturated Fatty Acids Indicate Pro- and Anti-Inflammatory Lipid Modifications in Synovial Membranes with Rheumatoid Arthritis

  2023cites this paper
• Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study

  2023cites this paper
• Identification of potential ferroptosis key genes and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis

  2023cites this paper
• Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes

  2022cites this paper
• PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis

  2022cites this paper
• Harnessing Inflammation Resolution in Arthritis: Current Understanding of Specialized Pro-resolving Lipid Mediators’ Contribution to Arthritis Physiopathology and Future Perspectives

  2021cites this paper
• Insulin Signaling in Arthritis

  2021cites this paper
• 15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay

  2021cites this paper
• MicroRNAs in shaping the resolution phase of inflammation.

  2021cites this paper
• Fatty Acids and Oxylipins in Osteoarthritis and Rheumatoid Arthritis—a Complex Field with Significant Potential for Future Treatments

  2021cites this paper
• Synovial Fluid Fatty Acid Profiles Are Differently Altered by Inflammatory Joint Pathologies in the Shoulder and Knee Joints

  2021cites this paper
• Virtual Screening Technique Used to Estimate the Mechanism of Adhatoda vasica Nees for the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking

  2020cites this paper
• Association between thiazolidinedione use and rheumatoid arthritis risk in patients with type II diabetes, a population‐based, case‐control study

  2020cites this paper
• L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis

  2020cites this paper
• Role of Lipocalin‐Type Prostaglandin D Synthase in Experimental Osteoarthritis

  2020cites this paper
• PPARs and Angiogenesis—Implications in Pathology

  2020cites this paper
• Anti‐inflammatory effect of omega unsaturated fatty acids and dialysable leucocyte extracts on collagen‐induced arthritis in DBA/1 mice

  2020cites this paper
• Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo

  2020cites this paper
• Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J2) for effective treatment and reduction in the death toll

  2020cites this paper
• PPARγ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT-1 in vivo and in vitro.

  2019cites this paper
• Regulation of host cell pyroptosis and cytokines production by Mycobacterium tuberculosis effector PPE60 requires LUBAC mediated NF-κB signaling.

  2019cites this paper
• A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis

  2019cites this paper
• Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis

  2019cites this paper
• DDDT_A_206695 1879..1888

  2019influential citation
• Interleukin-6 and tumour necrosis factor-α cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells

  2019cites this paper
• 15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review

  2019influential citation
• Peroxisome proliferator‐activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro

  2019cites this paper
• Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: Synthesis, optimization, in vitro and in vivo evaluation.

  2019cites this paper
• On the Mechanisms of Action of the Low Molecular Weight Fraction of Commercial Human Serum Albumin in Osteoarthritis

  2019cites this paper
• Altered Gut Microbiota in Myasthenia Gravis

  2018cites this paper
• A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.

  2018cites this paper
• Role of prostanoids in gastrointestinal cancer.

  2018cites this paper
• Saibokuto as a Possible Therapy for Type B Insulin Resistance Syndrome: The Disappearance of Anti-insulin Receptor Antibody and a Marked Amelioration of Glycemic Control by Saibokuto Treatment

  2018cites this paper
• Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ

  2018cites this paper
• GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis

  2018cites this paper
• ANTI-ARTHRITIC POTENCIES OF PPAR-AND PPAR-AGONIST IN RHEUMATOID ARTHRITIS

  2017cites this paper
• Nonsteroidal Anti‐Inflammatory Therapy: A Journey Toward Safety

  2017cites this paper
• Biological Actions of PPAR-in Health and Disease

  2017cites this paper
• Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion

  2016cites this paper
• Peroxisome proliferator-activated receptor gamma expression in peripheral monocytes from rheumatoid arthritis patients

  2016cites this paper
• Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death

  2016cites this paper
• Lipid Mediators in Inflammation

  2016cites this paper
• Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease

  2016cites this paper
• The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes

  2015cites this paper
• Developing an in vitro model of haemorrhagic shock to investigate the molecular mechanism of valproic acid in the treatment of massive blood loss

  2015cites this paper
• Monocarboxylate Transporter 4, Associated With the Acidification of Synovial Fluid, Is a Novel Therapeutic Target for Inflammatory Arthritis

  2015cites this paper
• Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma

  2015cites this paper
• Inflammatory Pathways in Knee Osteoarthritis: Potential Targets for Treatment

  2015cites this paper
• Cellular Metabolism and Macrophage Functional Polarization

  2015cites this paper
• Persisting eicosanoid pathways in rheumatic diseases

  2014cites this paper
• Arthritic Cell-Based Assay Model For Measuring Inflammatory Response To Therapeutic Biological Agents

  2014cites this paper
• Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis.

  2014cites this paper
• 15-Deoxy-Δ12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells.

  2014cites this paper
• Sonoporation-mediated transduction of siRNA ameliorated experimental arthritis using 3 MHz pulsed ultrasound.

  2014cites this paper
• Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis.

  2014cites this paper
• The Peroxisome Proliferator Activated Receptor‐γ Pioglitazone Improves Vascular Function and Decreases Disease Activity in Patients With Rheumatoid Arthritis

  2013cites this paper
• The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology.

  2013cites this paper
• Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis.

  2013cites this paper
• Peroxisome proliferator-activated receptor-γ agonist pioglitazone suppresses experimental autoimmune uveitis.

  2013cites this paper
• Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats

  2013cites this paper
• PPARγ delivered by Ch-GNPs onto titanium surfaces inhibits implant-induced inflammation and induces bone mineralization of MC-3T3E1 osteoblast-like cells.

  2013cites this paper
• Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis

  2013cites this paper
• The need for physiologically relevant peroxisome proliferator-activated receptor-gamma (PPAR-γ) ligands.

  2013cites this paper
• Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils

  2012cites this paper
• Functional change of synoviocytes and mesenchymal stromal cells through adipogenesis: A possible model of pannus and bone edema formation in rheumatoid arthritis

  2012cites this paper
• The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection.

  2012cites this paper
• Peroxisome proliferator-activated receptor-gamma expression in monocytes/macrophages from rheumatoid arthritis patients: relation to disease activity and therapy efficacy--a pilot study.

  2012cites this paper
• Peroxisome Proliferator-Activated Receptor γ B Cell-Specific–Deficient Mice Have an Impaired Antibody Response

  2012cites this paper
• Involvement of mitogen-activated protein kinases and peroxisome proliferator-activated receptor γ in monosodium urate crystal-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts.

  2012cites this paper
• This information is current as Impaired Antibody Response Deficient Mice Have an − B Cell-Specific γ Peroxisome Proliferator-Activated Receptor

  2012cites this paper
• Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy

  2012cites this paper
• Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis - a randomized controlled human intervention trial

  2011cites this paper
• Statins and the joint: multiple targets for a global protection?

  2011cites this paper
• Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells.

  2011cites this paper
• Increased synovial expression of nuclear receptors correlates with protection in pristane-induced arthritis: a possible novel genetically regulated homeostatic mechanism.

  2011cites this paper
• 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling.

  2011cites this paper
• Effects of 15d‐PGJ2‐loaded poly(D,L‐lactide‐co‐glycolide) nanocapsules on inflammation

  2011cites this paper
• Peroxisome proliferator-activated receptor gamma in osteoarthritis

  2011cites this paper
• Anti-inflammatory mediators as physiological and pharmacological regulators of parturition

  2011cites this paper
• 15‐deoxy‐Δ12,14‐prostaglandin‐J2 and ciglitazone inhibit TNF‐α‐induced matrix metalloproteinase 13 production via the antagonism of NF‐κB activation in human synovial fibroblasts

  2011cites this paper
• Old and new generation lipid mediators in acute inflammation and resolution.

  2011cites this paper
• Obesity, adipose tissue and rheumatoid arthritis: coincidence or more complex relationship?

  2011cites this paper
• Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics

  2011cites this paper
• 15-Deoxy-Δ12,14 Prostaglandin J2 Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

  2011cites this paper
• Lipid Signaling and Inflammation in Macrophages and Dendritic Cells Role of Liver X Receptor in Dendritic Cell Biology

  2010cites this paper
• Eicosanoids and the endogenous control of acute inflammatory resolution.

  2010cites this paper
• Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction.

  2010cites this paper
• Aberrant Reactive Oxygen and Nitrogen Species Generation in Rheumatoid Arthritis (RA): Causes and Consequences for Immune Function, Cell Survival, and Therapeutic Intervention

  2010cites this paper
• Emerging roles of SUMO modification in arthritis.

  2010cites this paper
• Telmisartan inhibits human urological cancer cell growth through early apoptosis.

  2010cites this paper
• Voies de signalisation du neutrophile humain dans le contexte de l'arthrite goutteuse

  2010cites this paper
• Crystal‐induced neutrophil activation

  2010cites this paper
• A clinical update on peroxisome proliferator-activated receptors

  2010cites this paper
• Resolution of Adipose Tissue Inflammation

  2010cites this paper