The role of poly ADP-ribosylation in the first wave of DNA damage response

Abstract Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after the induction of DNA single- or double-strand breaks. PARylation occurs at or near the sites of DNA damage and promotes the recruitment of DNA repair factors via their poly ADP-ribose (PAR) binding domains. Several novel PAR-binding domains have been recently identified. Here, we summarize these and other recent findings suggesting that PARylation may be the critical event that mediates the first wave of the DNA damage response. We also discuss the potential for functional crosstalk with other DNA damage-induced post-translational modifications.

• Publication year

  2017

• Venue

  Nucleic Acids Research

• Publication date

  2017-07-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/nar/gkx565PMID 28854736PMCID 5737498
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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