Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Immunity

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.immuni.2017.08.018PMID 28930665PMCID PMC5664180
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tissue‐Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

  2017cited by this paper
• Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

  2016cited by this paper
• Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

  2016cited by this paper
• Tissue-Resident Macrophage Ontogeny and Homeostasis.

  2016cited by this paper
• Tumor macrophages are pivotal constructors of tumor collagenous matrix

  2016cited by this paper
• Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

  2016cited by this paper
• The development and maintenance of resident macrophages

  2015cited by this paper
• PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

  2015cited by this paper
• CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

  2015cited by this paper
• Macrophages: development and tissue specialization.

  2015cited by this paper
• C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.

  2015influential reference
• Macrophages and therapeutic resistance in cancer.

  2015cited by this paper
• Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

  2014cited by this paper
• Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

  2014cited by this paper
• The cellular and molecular origin of tumor-associated macrophages

  2014influential reference
• Pharmacological modulation of monocytes and macrophages.

  2014cited by this paper
• Progressive replacement of embryo-derived cardiac macrophages with age

  2014cited by this paper
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.

  2013influential reference
• Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

  2013cited by this paper
• Faculty Opinions recommendation of Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.

  2013influential reference
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

  2012cited by this paper
• Immunometabolism: Adipose tissue inflammation

  2012influential reference
• A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

  2012influential reference
• Significance of M2-polarized tumor-associated macrophage in pancreatic cancer.

  2011cited by this paper
• The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

  2011influential reference
• CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

  2011cited by this paper
• Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

  2011cited by this paper
• All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells.

  2011cited by this paper
• Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.

  2010cited by this paper

• Absence of Interstitial Cells of Cajal in Human Colonic Muscularis Mucosae: Implications for Mucosal Motility Control.

  2026cites this paper
• A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity.

  2026cites this paper
• Therapeutic targeting of FOSL1 and RELA-dependent transcriptional mechanisms to suppress pancreatic cancer metastasis

  2025cites this paper
• Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for colorectal cancer

  2025cites this paper
• Emerging therapeutics targeting tumor-associated macrophages for the treatment of solid organ cancers

  2025cites this paper
• Therapeutic targeting of tumour-associated macrophage receptors

  2025cites this paper
• Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation

  2025cites this paper
• Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention

  2025cites this paper
• Tissue-resident immune cells: from defining characteristics to roles in diseases

  2025cites this paper
• ADAM17-dependent Autocrine and Paracrine Signaling Promotes Pancreatic Premalignant Progression

  2025cites this paper
• Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traits

  2025cites this paper
• Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer

  2025cites this paper
• Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer

  2025cites this paper
• Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic Approaches

  2025cites this paper
• DPP7 promotes fatty acid β-oxidation in tumor-associated macrophages and determines immunosuppressive microenvironment in colorectal cancer

  2025cites this paper
• Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma

  2025cites this paper
• Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advances

  2025cites this paper
• Modulation of infiltrating CD206+ macrophages restricts progression of pulmonary lymphangioleiomyomatosis

  2025cites this paper
• DTractor enhances cell type deconvolution in spatial transcriptomics by integrating deep neural networks, transfer learning, and matrix factorization

  2025cites this paper
• Acinar cells modulate the tumor microenvironment through the promotion of M1 macrophage polarization via macrophage endocytosis in pancreatic cancer

  2025cites this paper
• TAMs-derived IL-1β inducing DDX21 enhances CRC proliferation and metastasis via JAK2/STAT3 pathway.

  2025cites this paper
• Probiotics Mitigate High-cholesterol Diet-driven Fatty Liver and Pancreatic Cancer by Restoring Macrophage Homeostasis

  2025cites this paper
• Pan-Cancer Single-Cell RNA Sequencing Analysis Refines Multi-Origin Monocyte and Macrophage Lineages

  2025cites this paper
• Mechano-regulation of cancer cell memory in tumor progression and therapy

  2025cites this paper
• The origin and polarization of Macrophages and their role in the formation of the Pre-Metastatic niche in osteosarcoma.

  2025cites this paper
• Harnessing Macrophages in Cancer Therapy: from Immune Modulators to Therapeutic Targets

  2025cites this paper
• Targeting the Tumor Immune Microenvironment in Triple-Negative Breast Cancer: The Promise of Polyphenols

  2025cites this paper
• Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints.

  2025cites this paper
• Synergistic Effects of Radiotherapy and PD‑1 Blockade in a Human‑Mimetic BRCAness Model of Triple-Negative Breast Cancer

  2025cites this paper
• PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

  2025cites this paper
• Macrophages and T cells in metabolic disorder-associated cancers

  2024cites this paper
• CD71 expressing circulating neutrophils serve as a novel prognostic biomarker for metastatic spread and reduced outcome in pancreatic ductal adenocarcinoma patients

  2024cites this paper
• The fatty acid receptor CD36 promotes macrophage infiltration via p110γ signaling to stimulate metastasis

  2024cites this paper
• Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer

  2024cites this paper
• Gastric cancer immunosuppressive microenvironment heterogeneity: implications for therapy development.

  2024cites this paper
• TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function

  2024cites this paper
• Macrophages in tumor cell migration and metastasis

  2024cites this paper
• Unveiling the immunosuppressive landscape of pancreatic ductal adenocarcinoma: implications for innovative immunotherapy strategies

  2024cites this paper
• Overcoming the limitations of immunotherapy in pancreatic ductal adenocarcinoma: Combining radiotherapy and metabolic targeting therapy

  2024cites this paper
• Development of a customizable mouse backbone spectral flow cytometry panel to delineate immune cell populations in normal and tumor tissues

  2024cites this paper
• The promising role of tumor-associated macrophages in the treatment of cancer.

  2024cites this paper
• Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing

  2024influential citation
• A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

  2024cites this paper
• Pirfenidone alleviates fibrosis by acting on tumour–stroma interplay in pancreatic cancer

  2024cites this paper
• Unravelling monocyte functions: from the guardians of health to the regulators of disease

  2024cites this paper
• Natural plant-derived polysaccharides targeting macrophage polarization: a promising strategy for cancer immunotherapy

  2024cites this paper
• Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

  2024cites this paper
• The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of Mice

  2024cites this paper
• Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer.

  2024cites this paper
• Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling

  2024influential citation
• The role of macrophage migratory behavior in development, homeostasis and tumor invasion

  2024cites this paper
• A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

  2024cites this paper
• Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions

  2024cites this paper
• Microbiota in cancer: molecular mechanisms and therapeutic interventions

  2023cites this paper
• IL-1β^+ macrophages fuel pathogenic inflammation in pancreatic cancer

  2023cites this paper
• Roles of differently polarized macrophages in the initiation and progressionof pancreatic cancer

  2023cites this paper
• Anemia, Iron Deficiency, and Iron Regulators in Pancreatic Ductal Adenocarcinoma Patients: A Comprehensive Analysis

  2023cites this paper
• Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression

  2023cites this paper
• An integrated overview of the immunosuppression features in the tumor microenvironment of pancreatic cancer

  2023cites this paper
• Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

  2023cites this paper
• Characterization of 3D heterocellular spheroids of pancreatic ductal adenocarcinoma for the study of cell interactions in the tumor immune microenvironment

  2023influential citation
• Tumor-associated macrophages in canine visceral hemangiosarcoma

  2023cites this paper
• An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

  2023cites this paper
• Intraperitoneal metastasis of ovarian cancer: new insights on resident macrophages in the peritoneal cavity

  2023cites this paper
• Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

  2023cites this paper
• Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

  2023cites this paper
• Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

  2023cites this paper
• The Roles and Targeting of Tumor-Associated Macrophages.

  2023cites this paper
• Single-cell RNA datasets and bulk RNA datasets analysis demonstrated C1Q+ tumor-associated macrophage as a major and antitumor immune cell population in osteosarcoma

  2023cites this paper
• Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

  2023cites this paper
• Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes

  2023cites this paper
• Tissue‐resident CXCR4+ macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression

  2023cites this paper
• EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice

  2023cites this paper
• The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression

  2023cites this paper
• S100A11: A Potential Carcinogen and Prognostic Marker That Correlates with the Immunosuppressive Microenvironment in Pan-Cancer

  2023cites this paper
• The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers

  2023cites this paper
• The Microbiome-TIME Axis: A Host of Possibilities

  2023cites this paper
• Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment

  2023cites this paper
• Gli3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival

  2023cites this paper
• Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

  2023cites this paper
• Pancreatic cancer: Advances and challenges

  2023cites this paper
• EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

  2023cites this paper
• Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

  2023cites this paper
• Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursors

  2023cites this paper
• G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans

  2023cites this paper
• Tumor-associated myeloid cells in cancer immunotherapy

  2023cites this paper
• Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

  2022cites this paper
• Tissue-Resident Innate Immune Cell-Based Therapy: A Cornerstone of Immunotherapy Strategies for Cancer Treatment

  2022influential citation
• Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages

  2022cites this paper
• Targeting the Tumor Microenvironment: A Close Up of Tumor-Associated Macrophages and Neutrophils

  2022cites this paper
• LOXL2 in pancreatic tumourigenesis: the complexity of tumour–stromal crosstalk exemplified

  2022cites this paper
• Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress

  2022cites this paper
• Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

  2022cites this paper
• Cutting edge: the regulatory mechanisms of macrophage polarization and function during pregnancy.

  2022cites this paper
• Murine Chronic Pancreatitis Model Induced by Partial Ligation of the Pancreatic Duct Encapsulates the Profile of Macrophage in Human Chronic Pancreatitis

  2022cites this paper
• Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer.

  2022cites this paper
• Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway

  2022cites this paper
• An Integrated Pan-Cancer Analysis of ADAMTS12 and Its Potential Implications in Pancreatic Adenocarcinoma

  2022cites this paper
• βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer

  2022cites this paper
• Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

  2022cites this paper