Effect of Insecticide Resistance on Development, Longevity and Reproduction of Field or Laboratory Selected Aedes aegypti Populations

Aedes aegypti dispersion is the major reason for the increase in dengue transmission in South America. In Brazil, control of this mosquito strongly relies on the use of pyrethroids and organophosphates against adults and larvae, respectively. In consequence, many Ae. aegypti field populations are resistant to these compounds. Resistance has a significant adaptive value in the presence of insecticide treatment. However some selected mechanisms can influence important biological processes, leading to a high fitness cost in the absence of insecticide pressure. We investigated the dynamics of insecticide resistance and its potential fitness cost in five field populations and in a lineage selected for deltamethrin resistance in the laboratory, for nine generations. For all populations the life-trait parameters investigated were larval development, sex ratio, adult longevity, relative amount of ingested blood, rate of ovipositing females, size of egglaying and eggs viability. In the five natural populations, the effects on the life-trait parameters were discrete but directly proportional to resistance level. In addition, several viability parameters were strongly affected in the laboratory selected population compared to its unselected control. Our results suggest that mechanisms selected for organophosphate and pyrethroid resistance caused the accumulation of alleles with negative effects on different life-traits and corroborate the hypothesis that insecticide resistance is associated with a high fitness cost.

• Publication year

  2012

• Venue

  PLoS ONE

• Publication date

  2012-03-14

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1371/journal.pone.0031889PMID 22431967PMCID 3303777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2009cited by this paper
• Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil.

  2009cited by this paper
• Embryonic development of Aedes aegypti (Diptera: Culicidae): influence of different constant temperatures.

  2009cited by this paper
• A mutation in the voltage‐gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti

  2007cited by this paper
• Insecticide resistance mechanisms of Brazilian Aedes aegypti populations from 2001 to 2004.

  2007cited by this paper
• PYRETHROID INSECTICIDE-RESISTANT STRAIN OF AEDES AEGYPTI FROM CUBA INDUCED BY DELTAMETHRIN SELECTION

  2005cited by this paper
• Monitoring of resistance to the pyrethroid cypermethrin in Brazilian Aedes aegypti (Diptera: Culicidae) populations collected between 2001 and 2003.

  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• Deltamethrin resistance in the codling moth (Lepidoptera: Tortricidae): inheritance and number of genes involved

  2001cited by this paper
• Deltamethrin tolerance & associated cross resistance in Aedes aegypti from Mysore.

  2001cited by this paper
• Insecticide resistance in insect vectors of human disease.

  2000cited by this paper
• Inheritance of larval resistance to permethrin in Aedes aegypti and association with sex ratio distortion and life history variation.

  1997influential reference
• Permeability of intact and dechorionated eggs of the Anopheles mosquito to water vapor and liquid water: a comparison with Drosophila.

  1996cited by this paper
• Scalloped wings is the Lucilia cuprina Notch homologue and a candidate for the modifier of fitness and asymmetry of diazinon resistance.

  1996cited by this paper
• Life-history costs associated with the evolution of insecticide resistance

  1994cited by this paper
• Behaviour and fitness of γHCH/dieldrin resistant and susceptible female Anopheles gambiae and An.stephensi mosquitoes in the absence of insecticide

  1991cited by this paper
• Activity and mating competitiveness of γHCH/dieldrin resistant and susceptible male and virgin female Anopheles gambiae and An.stephensi mosquitoes, with assessment of an insecticide‐rotation strategy

  1991cited by this paper
• Inheritance and fitness consequences of resistance to fenvalerate in Spodoptera exigua (Lepidoptera: Noctuidae)

  1991cited by this paper
• The effect of new environment on adapted genetic architecture

  1990cited by this paper
• The hitch-hiking effect of a favourable gene.

  1974cited by this paper
• REPRODUCTIVE ISOLATION IN STEGOMYIA MOSQUITOES. II. HYBRID BREAKDOWN BETWEEN AEDES AEGYPTI AND A. MASCARENSIS

  1970cited by this paper
• Further comments on the susceptibility of Aedes acgypti to DDT in the Miami, Florida, area.

  1961cited by this paper
• DDT-resistance hazard in North American populations of Aedes aegypti.

  1961cited by this paper
• The Genetical Theory of Natural Selection

  1930cited by this paper

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• Are fitness costs associated with insecticide resistance? A meta-analysis.

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  2024cites this paper
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